Outcomes of endoscopic submucosal dissection for early esophageal and gastric cardia adenocarcinomas

Doumbe-Mandengue, Paul; Beuvon, Frédéric; Belle, Arthur; Dermine, Solène; Palmieri, Lola‐Jade; Ali, Einas Abou; Hallit, Rabih; Leconte, Mahaut; Dohan, Anthony; Bibault, Jean‐Emmanuel; Terris, Benoı̂t; Chaussade, Stanislas; Barret, Maximilien

doi:10.1016/j.clinre.2021.101700

Cited by 9 publications

(9 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The recurrence rate was low, ranging from 0-19% in EA and 0-2.4% in GCA. Doumbe-Mandengue et al found a 19% recurrence rate for EA, as this study mixed actual local recurrences and metachronous lesions [ 34 ]. Likewise, the overall survival rate was superior to 89% in all studies but one, as Hoteya et al in 2013 found a 74% overall survival rate [ 31 ].…”

Section: Resultsmentioning

confidence: 85%

“…All the other publications were eastern Asian studies. Four studies were designed to compare EA with GCA [ 31 - 34 ].…”

Section: Resultsmentioning

confidence: 99%

“…Notably, 2/17 (12%) studies for EA and 2/6 (33%) studies for GCA did not mention their R0 resection rate [ 32 , 38 , 39 ]. In the 4 studies that directly compared EA to GCA, 1 found an R0 resection rate significantly higher in the gastric cardia group (99/103 or 96.1% vs. 16/25 or 64%, P<0.05) [ 31 ], 2 found no differences [ 33 , 34 ], and 1 did not assess this variable but found a curative resection rate significantly higher in the gastric cardia group (71/87 or 81.6% vs. 34/55 or 61.8%, P=0.01) [ 32 ].…”

Section: Resultsmentioning

confidence: 99%

“…The late adverse events were mostly explained by strictures and delayed bleedings. Of the 15 studies that assessed late adverse events after the resection of EA, 6 found a late adverse events rate ranging between 0% and 5% [ 25 , 26 , 29 , 33 , 36 ], 2 found between 5% and 10% [ 24 , 35 ], 6 between 10% and 20% [ 27 , 28 , 34 , 37 , 40 , 41 ], while 1 reported a 60% late adverse events rate [ 38 ]. The 4 studies designed to compare EA to GCA did not find any significant differences between early or late adverse events in these 2 types of cancer.…”

Section: Resultsmentioning

confidence: 99%

“…If the definition of an en bloc resection is consensual, the definitions of histologically complete (R0) and curative resection are controversial. Probst et al , Barret et al and Doumbe-Mandengue et al , in studies evaluating the efficacy of ESD for EA, distinguished 2 different definitions for R0 resections: cancer-free margins, and high-grade dysplasia-free margins [ 24 , 34 , 35 ]. In our work, we decided to use the outcomes of the “high-grade dysplasia-free margins” definition, in order to homogenize the results.…”

Section: Methodsmentioning

confidence: 99%

See 4 more Smart Citations

Endoscopic submucosal dissection for early esophagogastric junction adenocarcinomas: a systematic review

Doumbe-Mandengue

Pellat

Terris

et al. 2022

aog

Self Cite

View full text Add to dashboard Cite

Background Esophagogastric junction adenocarcinomas (EGJAs) include esophageal and gastric cardia adenocarcinomas (GCAs). These tumors are currently regarded as a single entity, with similar surgical and oncological therapies, although they originate from different organs. Endoscopy allows an early-stage diagnosis, where both subtypes can be differentiated. With this review we aimed to describe the outcomes of endoscopic submucosal dissection for the treatment of esophageal adenocarcinomas (EAs) and GCAs. Methods We identified studies by screening PubMed, Embase and Web of Science. We included all 19 studies that mentioned at least one of the following criteria of interest: en bloc ; R0 resection; local recurrences; and/or overall survival. Results We found an en bloc resection rate superior to 90% for both tumors. R0 resections rates were over 60% for most EAs, vs. 83% for most GCAs. We recorded less than 13% and 20% early and late adverse events for EA, and 10% and 7% for GCA. The local recurrence rate was 8% for EA and 3% for GCA. The overall survival was over 90%. Conclusions Endoscopic submucosal dissection is safe and effective for esophageal and GCAs. These data support the extension of the use of endoscopic submucosal dissection to all EGJAs, including early EAs.

show abstract

Section: Resultsmentioning

confidence: 85%

“…All the other publications were eastern Asian studies. Four studies were designed to compare EA with GCA [ 31 - 34 ].…”

Section: Resultsmentioning

confidence: 99%