“…In humans, there are seven sirtuins (SIRT1-7), with different acyl group specificities and subcellular localizations. Through deacylation, sirtuins regulate a wide range of biological functions, such as cell proliferation, metabolism, transcription, apoptosis, and cell signaling (Avalos et al, 2005;Machado de Oliveira et al, 2012;Morris, 2013;Hu et al, 2014;Jing and Lin, 2015;Bheda et al, 2016;Blank et al, 2017;Cha et al, 2017;Kosciuk et al, 2019;Wang and Lin, 2021). Consequently, sirtuins have been linked to various diseases, including cancer, neurological, and cardiovascular diseases (Borradaile and Pickering, 2009;Haigis and Sinclair, 2010;Hu et al, 2014;Fujita and Yamashita, 2018).…”