Shenfu injection alleviates the clinical symptoms of heart failure patients combined with conventional treatment

Abstract

Background: Shenfu Injection (SFI) is a promising alternative treatment for heart failure (HF) in China. Many complete clinical trials have examined the efficacy of SFI combined use with conventional treatment (CT) vs CT alone. This study is to conduct a systematic review and meta-analysis of randomized clinical trials to evaluate the benefits and risks of using SFI in addition to CT for the treatment of HF. Method: All the trials will be searched through 4 English databases (MEDLINE via PubMed, the Cochrane Library, EMBASE, Web of Science) and 4 Chinese databases (the China Science and Technology Journal Database, Chinese Biomedical Literature Database, Wan-fang Database, the China National Knowledge Infrastructure.) from October 2005 to June 2019. Conference articles or articles with incomplete data will be removed. The primary outcome was the New York Heart Association, 6-minute walk test, hospitalization or rehospitalization. Left ventricular ejection fraction percentage, left ventricular end-diastolic dimension, Cardiac index, heart rate, N-terminal pronatriuretic peptide and other indicators were also assessed. RevMan V.5.3 Software and Stata 13.0 Statistics Software were used to calculate the data synthesis and conduct meta-analysis according to the guideline of Preferred Reporting Items for Systematic Reviews and Meta-analyses Protocols 2015. Results: Mortality, New York Heart Association function classification, heart rate, 6-minute walk test, hospitalization or rehospitalization, Heart rate, systolic blood pressure, DBP, Cardiac minute volume, left ventricular ejection fractions percentage, left ventricular end-diastolic dimension (mm), N-terminal pronatriuretic peptide, etc. and adverse effects will be comprehensively assessed to evaluate the adjunctive effect of SFI through different aspects. We will perform a meta-analysis of each outcome with subgroup analysis based on the type of HF, treatment methods, and course of disease. Sensitivity analysis will be conducted with clinical factors, treatment methods, methodological characteristics, and statistical heterogeneity (if applicable). Conclusion: This study will assess the adjunctive effect of SFI and its safety on HF with clinical evidence. PROSPERO registration number: PROSPERO CRD42020151856

Shenfu injection improves isoproterenol-induced heart failure in rats by modulating co-metabolism and regulating the trimethylamine-N-oxide - inflammation axis

“…Shenfu injection (SFI) is one of the representative prescriptions of the warming Yang method. It originates from the classic formula Shenfu Decoction and continues to be applied extensively in the treatment of heart failure with remarkable curative effects (Luo et al, 2021 (Wu H. et al, 2019;Wang et al, 2021). In addition, a study by Zhu et al demonstrated that this intervention can mitigate myocardial injury through the prevention of mitochondrial apoptosis and facilitating vasodilation by augmenting eNOS activity via the PI3K/Akt signaling pathway (Zhu et al, 2020).…”

“…Shenfu injection (SFI) is one of the representative prescriptions of the warming Yang method. It originates from the classic formula Shenfu Decoction and continues to be applied extensively in the treatment of heart failure with remarkable curative effects ( Luo et al, 2021 ). Currently, SFI is a formulation created with Panax ginseng C.A.…”

Therapeutic Mechanism and Key Active Ingredients of Shenfu Injection in Sepsis: A Network Pharmacology and Molecular Docking Approach

“…(hongshen) and Aconitum carmichaeli Debx (fuzi). In clinical treatment, SFI has been widely used to treat a variety of diseases including sepsis [3,4], shock [5], and heart failure [6] with good curative e ects. Experimental evidence supports that SFI is e ective in improving immune function in patients with sepsis [7,8], reducing septic lung injury [9], and improving the prognosis for patients with sepsis [7,10,11].…”

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“…Shenfu injection (SFI) is one of the representative prescriptions of the warming Yang method. It originates from the classic formula Shenfu Decoction and continues to be applied extensively in the treatment of heart failure with remarkable curative effects (Luo et al, 2021 (Wu H. et al, 2019;Wang et al, 2021). In addition, a study by Zhu et al demonstrated that this intervention can mitigate myocardial injury through the prevention of mitochondrial apoptosis and facilitating vasodilation by augmenting eNOS activity via the PI3K/Akt signaling pathway (Zhu et al, 2020).…”