An insight into the promoter methylation of PHF20L1 and the gene association with metastasis in breast cancer

Sierra-Ramírez, José Alfredo; Seseña, Emmanuel; Godínez‐Victoria, Marycarmen; Hernández-Caballero, Marta Elena

doi:10.17219/acem/133426

Cited by 3 publications

(1 citation statement)

References 30 publications

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“…Another histone demethylase PHF8 promoted EMT and breast tumorigenesis ( 140 ). PHF20L1, a methyl lysine reader protein containing a TUDOR domain, plays important role in breast cancer metastasis ( 141 ). Studies suggested its oncogenic role in response to hypoxic conditions, where it facilitated glycolysis, cell growth and metastasis of breast cancer cells by exerting its direct inhibitory activities on certain genes of tumor suppressive nature like HIC1 , KISS1 , and BRCA1 ( 142 ).…”

Section: Epigenetic Players In Breast Cancermentioning

confidence: 99%

Epigenetics and environment in breast cancer: New paradigms for anti-cancer therapies

Thakur

Qiu²,

Fu³

et al. 2022

Front. Oncol.

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Breast cancer remains the most frequently diagnosed cancer in women worldwide. Delayed presentation of the disease, late stage at diagnosis, limited therapeutic options, metastasis, and relapse are the major factors contributing to breast cancer mortality. The development and progression of breast cancer is a complex and multi-step process that incorporates an accumulation of several genetic and epigenetic alterations. External environmental factors and internal cellular microenvironmental cues influence the occurrence of these alterations that drives tumorigenesis. Here, we discuss state-of-the-art information on the epigenetics of breast cancer and how environmental risk factors orchestrate major epigenetic events, emphasizing the necessity for a multidisciplinary approach toward a better understanding of the gene-environment interactions implicated in breast cancer. Since epigenetic modifications are reversible and are susceptible to extrinsic and intrinsic stimuli, they offer potential avenues that can be targeted for designing robust breast cancer therapies.

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Section: Epigenetic Players In Breast Cancermentioning

confidence: 99%

Epigenetics and environment in breast cancer: New paradigms for anti-cancer therapies

Thakur

Qiu²,

Fu³

et al. 2022

Front. Oncol.

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PHF20L1 mediates PAX2 expression to promote angiogenesis and liver metastasis in colorectal cancer through regulating HIC1

Zhu

Sun

Liang

et al. 2022

Biological Chemistry

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Colorectal cancer (CRC) is a common cancer with poor prognosis. The research was designed to explore the role of PHF20L1 in angiogenesis and liver metastasis in CRC and discuss its molecular mechanism. Expression levels of PHF20L1, HIC1 and PAX2 in CRC tissues collected from CRC patients were detected using qRT-PCR, WB and immunohistochemical staining. CRC cells were transfected with PHF20L1, HIC1 and PAX2 overexpression or knockdown vectors and the proliferation, apoptosis, EMT and angiogenesis of the cells were determined. WB was utilized to assess protein levels of PHF20L1, HIC1, PAX2 and angiogenesis factor (ANGPT2, FGF1, PDGFA and VEGFA). The role of PHF20L1 regulating tumor formation and liver metastasis in vivo was detected as well. PHF20L1 was observed to express at a high level of CRC tissues. PHF20L1 promoted CRC cell growth, EMT and angiogenesis, and inhibited cell apoptosis. Knockdown of PHF20L1 had opposite effects on CRC cells. PHF20L1 negatively regulated HIC1 expression to promote PAX2 expression, thus promoting CRC cell progression. The in vivo results showed that PHF20L1 contributed to tumor formation and liver metastasis. PHF20L1 increases PAX2 expression to promote angiogenesis in CRC by inhibiting HIC1, therefore facilitating CRC cell EMT and liver metastasis. Our finding may provide a novel insight for CRC pathogenesis.

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Diagnostic and Prognostic Performance of Liquid Biopsy-Derived Exosomal MicroRNAs in Thyroid Cancer Patients: A Systematic Review and Meta-Analysis

Toraih

Elshazli

Trinh

et al. 2021

Cancers

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Circulatory tumor-derived exosomal microRNAs (miRNAs) play key roles in cancer development/progression. We aimed to assess the diagnostic/prognostic value of circulating exosomal miRNA in thyroid cancer (TC). A search in PubMed, Scopus, Web of Science, and Science Direct up to 22 May 2021 was performed. The true/false positive (TP/FP) and true/false negative (TN/FN) rates were extracted from each eligible study to obtain the pooled sensitivity, specificity, positive/negative likelihood ratios (PLR/NLR), diagnostic odds ratio (DOR), and their 95% confidence intervals (95%CIs). The meta-analysis included 12 articles consisting of 1164 Asian patients and 540 controls. All miRNAs were quantified using qRT-PCR assays. The pooled sensitivity was 82% (95%CI = 77–86%), pooled specificity was 76% (95%CI = 71–80%), and pooled DOR was 13.6 (95%CI = 8.8–21.8). The best biomarkers with high sensitivity were miR-16-2-3p (94%), miR-223-5p (91%), miR-130a-3p (90%), and miR182-5p (94%). Similarly, they showed high specificity, in addition to miR-34c-5p. Six panels of two to four exosomal miRNAs showed higher diagnostic values with an area under the curve (AUC) ranging from 0.906 to 0.981. The best discriminative ability to differentiate between cancer and non-cancer individuals was observed for miR-146b-5p + miR-223-5p + miR-182-5p (AUC = 0.981, sensitivity = 93.8% (84.9–98.3), specificity = 92.9% (76.5–99.1)). In conclusion, the expression levels of exosomal miRNAs could predict TC.

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An insight into the promoter methylation of PHF20L1 and the gene association with metastasis in breast cancer

Abstract: Hernandez-Caballero ME. An insight into the promoter methylation of PHF20L1 and the gene association with metastasis in breast cancer.

Cited by 3 publications

References 30 publications

Epigenetics and environment in breast cancer: New paradigms for anti-cancer therapies

Epigenetics and environment in breast cancer: New paradigms for anti-cancer therapies

PHF20L1 mediates PAX2 expression to promote angiogenesis and liver metastasis in colorectal cancer through regulating HIC1

Diagnostic and Prognostic Performance of Liquid Biopsy-Derived Exosomal MicroRNAs in Thyroid Cancer Patients: A Systematic Review and Meta-Analysis

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