Sperm cryopreservation in adolescents with cancer

Reschini, Marco; Somigliana, Edgardo; Meazza, Cristina; Podda, Marta; Guarneri, Cristina; Giacchetta, Daniela; Massimino, Maura; Restelli, Liliana; Filippi, Francesca; Terenziani, Monica

doi:10.1016/j.ejogrb.2021.03.041

Cited by 5 publications

(5 citation statements)

References 20 publications

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“…In our study, most cryopreserved samples (75.6%) were collected by either patients with a testicular cancer or a hematological malignancy. These results are similar to previous studies with numbers of utilization ranging from 19 to 41.7% for testicular cancer and 35.4 to 71.7% for hematological malignancies (Bizet et al 2012 ; Depalo et al 2016 ; Reschini et al 2021 ). Among all samples cryopreserved in our department, only 10% were collected from under-aged cancer patients.…”

Section: Discussionsupporting

confidence: 92%

Sperm and testicular tissue cryopreservation and assisted reproductive technology outcomes in male cancer patients: a 15-year experience

Fernandez-González

Radauer-Plank

Stelzer

et al. 2022

J Cancer Res Clin Oncol

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Objective To explore the characteristics of cancer patients who cryopreserved sperm/testicular tissue samples in the Cryobank of Charité-Universitätsmedizin Berlin between 2004 and 2019, and the ART utilization rate with associated outcomes. Methods Retrospective data were available for 506 cancer patients, of which 46 (9.1%) had used their samples for artificial reproductive technologies (ART). Corresponding cycle information was collected from external fertility centers. Results Our cohort included 53/506 (10.5%) patients aged < 18 years at diagnosis. While adolescents and adults mainly banked sperm, adolescents showed higher rates of testicular tissue cryopreservation before (11.8%, 6/51 vs. 6.4%, 26/406) and after treatment (16.7%, 4/24 vs. 7.8%, 13/167). At study conduction, storage had been ended for 44.8% (269/601) of samples. The majority of samples used for ART were requested within the first 3 years after cryopreservation (71.5%, 28/39, range = 0–12 years). Pregnancy rate was 51.4% (19/37 cycles), resulting in 11 singleton births, 3 twin pairs, and 4 miscarriages. Conclusion With the new advantage of public health insurance coverage of fertility preservation (FP) in Germany, an increased utilization has already been noticed in our center, emphasizing the necessity of further knowledge for individual counseling. Adolescent cancer patients need to be addressed specifically, as these patients show especially low cryopreservation rates.

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Section: Discussionsupporting

confidence: 92%

Sperm and testicular tissue cryopreservation and assisted reproductive technology outcomes in male cancer patients: a 15-year experience

Fernandez-González

Radauer-Plank

Stelzer

et al. 2022

J Cancer Res Clin Oncol

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“…The average recovery rate was 49.92% ± 20.56%. Semen volume increased significantly with age (≤14 years old <19 years old, p = 0.01; 15 years old <19 years old, p = 0.023), which is consistent with previous report 28 . This may also reflect a still incomplete postpubertal maturation of the accessory glands of the genital tract.…”

Section: Resultssupporting

confidence: 90%

“…Semen volume increased significantly with age (≤14 years old <19 years old, p = 0.01; 15 years old <19 years old, p = 0.023), which is consistent with previous report. 28 This may also reflect a still incomplete postpubertal maturation of the accessory glands of the genital tract. The average semen volume was 2.93 ± 1.69 mL, and 71.6% of the semen volume was ≥2 mL.…”

Section: Semen Parametersmentioning

confidence: 99%

Fertility preservation in male adolescents with cancer (2011–2020): A retrospective study in China

Liu,

Wang,

Zhu

et al. 2024

Cancer Medicine

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BackgroundAccording to the studies, more than 80% of pediatric patients with cancer can achieve a survival rate greater than 5 years; however, long‐term chemotherapy and/or radiation therapy may seriously affect their reproductive ability. Fertility preservation in adolescents with cancer in China was initiated late, and related research is lacking. Analyze data to understand the current situation and implement measures to improve current practices.MethodsFrom 2011 to 2020, data on 275 male adolescents with cancer whose age ranged from 0 to 19 years old were collected from 16 human sperm banks for this retrospective study. Methods include comparing the basic situation of male adolescents with cancer, the distribution of cancer types, and semen quality to analyze the status of fertility preservation.ResultsThe mean age was 17.39 ± 1.46 years, with 13 cases (4.7%) aged 13–14 years and 262 cases (95.3%) aged 15–19 years. Basic diagnoses included leukemia (55 patients), lymphomas (76), germ cell and gonadal tumors (65), epithelial tumors (37), soft tissue sarcomas (14), osteosarcoma (7), brain tumors (5), and other cancers (16). There are differences in tumor types in different age stages and regions. The tumor type often affects semen quality, while age affects semen volume. Significant differences were found in sperm concentration and progressive motility before and after treatment (p < 0.001). Moreover, 90.5% of patients had sperm in their semen and sperm were frozen successfully in 244 patients (88.7%).ConclusionsThe aim of this study is to raise awareness of fertility preservation in male adolescents with cancer, to advocate for fertility preservation prior to gonadotoxic therapy or other procedures that may impair future fertility, and to improve the fertility status of future patients.

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“…However, beginning semen freezing at the age of 12 was already feasible. There were no significant differences in semen quality between age groups and semen parameters were comparable to those of adults, implying that even the youngest patients should consider having their spermatozoa frozen for potential benefit and future need [16][17][18]. In China, adolescents aged 15 to 21 years will not have reached the legal age for marriage; we had 50 cases (7.6%) of semen preservation in this age group.…”

Section: Discussionmentioning

confidence: 86%

An evaluation of the population characteristics, semen quality, and utilization status of autologous sperm cryopreservation and fertility preservation in for 662 patients: a 6-year monocentric retrospective study

Tang

Deng

Gao

et al. 2022

Basic Clin. Androl.

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Background Sperm cryopreservation is an effective method of fertility preservation for disease-related and social sperm freezing. In total, 662 subjects (range: 15–65 years-of-age; mean: 33.49 ± 8.79 years-of-age) were included in this study to investigate the population characteristics, semen quality, and usage of autologous sperm preservation patients in Beijing. Of these, 351 were cancer patients (53.02%, 31.14 ± 7.32 years-of-age) and 311 were non-cancer patients (46.98%, 36.14 ± 9.54 years-of-age). Results We found that the number of preservation cases increased steadily from 2015 to 2019; 89.73% of these had a bachelor's degree or above; 54.83%, 41.54%, and 3.63% were single, married, and divorced, respectively. The cases of cancers and oligozoospermia accounted for 71.30% of all patients; therefore, most patients required fertility preservation due to disease. The cancer group had a significantly lower sperm concentration, rate of progressive sperm after the frozen-thawed test, total progressive motility sperm count after the frozen-thawed test, and recovery rate of progressive motile sperm (RRPM) than the non-cancer group (all P < 0.05). Sperm count-related parameters were significantly affected by testicular cancer, while sperm motility-related parameters and RRPM were significantly affected by leukemia. The utilization rate of preserved sperm was 6.34% after 6 to 78 months of follow-up. In terms of fresh or frozen embryo transfer, the clinical pregnancy rate was 56.76% or 50.00%, and the live birth rate was 24.32% or 21.43%, respectively. Conclusion The need for autologous sperm preservation was dominated by patients with diseases, followed by the need for social sperm freezing. Tumors had a major negative impact on semen quality, and the usage rates of stored semen were at lower level compared to the number of sperm cryopreservation. Medical staff and patients should pay attention to both cognition-action consistency and cost-effectiveness in fertility preservation.

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Sperm cryopreservation in adolescents with cancer

Cited by 5 publications

References 20 publications

Sperm and testicular tissue cryopreservation and assisted reproductive technology outcomes in male cancer patients: a 15-year experience

Sperm and testicular tissue cryopreservation and assisted reproductive technology outcomes in male cancer patients: a 15-year experience

Fertility preservation in male adolescents with cancer (2011–2020): A retrospective study in China

An evaluation of the population characteristics, semen quality, and utilization status of autologous sperm cryopreservation and fertility preservation in for 662 patients: a 6-year monocentric retrospective study

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