Outcome of Repeat Venoarterial Extracorporeal Membrane Oxygenation in Postcardiotomy Cardiogenic Shock

Yusuff, Hakeem; Biancari, Fausto; Jónsson, Kristján; Ragnarsson, Sigurður; Dalén, Magnus; Fux, Thomas; Fiore, Antonio; Perna, Dario Di; Gatti, Giuseppe; Gabrielli, Marco; Juvonen, Tatu; Zipfel, S.; Bounader, Karl; Perrotti, Andréa; Loforte, Antonio; Lechiancole, Andrea; Pol, Marek; Pettinari, Matteo; Keyzer, Dieter De; Welp, Henryk; Maselli, Daniele; Alkhamees, Khalid; Ruggieri, Vito Giovanni; Mariscalco, Giovanni

doi:10.1053/j.jvca.2021.03.001

Cited by 2 publications

(2 citation statements)

References 16 publications

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“…Nevertheless, without further specification of the type of abnormality or clinical correlation, the severity of the neurological complication following repeat ECLS in the current investigation may have been underestimated. It is encouraging that in contrast to non-CDH populations 21,28–30 and non-neonatal patients, 31,32 neurological and functional morbidity in CDH survivors did not differ between 1 or multiple ECLS courses in other reports 9,33 . However, given the increased need for seizure medication at discharge and the known risk of neurodevelopmental impairment in CDH, 34–36 structured long-term outcome studies are urgently needed when considering this high-risk intervention 37 …”

Section: Discussionmentioning

confidence: 98%

Impact of Repeat Extracorporeal Life Support on Mortality and Short-term In-hospital Morbidities in Neonates With Congenital Diaphragmatic Hernia

et al. 2022

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Objective: To evaluate the impact of repeat extracorporeal life support (ECLS) on survival and in-hospital outcomes in the congenital diaphragmatic hernia (CDH) neonates. Background: Despite the widespread use of ECLS, investigations on multiple ECLS courses for CDH neonates are limited. Methods: This is a retrospective cohort study of all ECLS-eligible CDH neonates enrolled in the Congenital Diaphragmatic Hernia Study Group registry between 1995 and 2019. CDH infants with estimated gestational age at birth <32 weeks and a birth weight <1.8 kg and/or with major cardiac or chromosomal anomalies were excluded. The primary outcomes were survival and morbidities during the index hospitalization. Results: Of 10,089 ECLS-eligible CDH infants, 3025 (30%) received 1 ECLS course, and 160 (1.6%) received multiple courses. The overall survival rate for patients who underwent no ECLS, 1 ECLS course, and multicourse ECLS were 86.9±0.8%, 53.8±1.8%, and 43.1±7.7%, respectively. Overall ECLS survival rate is increased by 5.1±4.6% (P=0.03) for CDH neonates treated at centers that conduct repeat ECLS compared with those that do not offer repeat ECLS. This suggests that there would be an overall survival benefit from increased use of multiple ECLS courses. Infants who did not receive ECLS support had the lowest morbidity risk, while survivors of multicourse ECLS had the highest rates of morbidities during the index hospitalization. Conclusions: Although survival is lower for repeat ECLS, the use of multiple ECLS courses has the potential to increase overall survival for CDH neonates. Increased use of repeat ECLS might be associated with improved survival. The potential survival advantage of repeat ECLS must be balanced against the increased risk of morbidities during the index hospitalization.

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Section: Discussionmentioning

confidence: 98%

Impact of Repeat Extracorporeal Life Support on Mortality and Short-term In-hospital Morbidities in Neonates With Congenital Diaphragmatic Hernia

et al. 2022

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“…There were 781 patients and 242 variables in the registry from 19 cardiac centers in different European and Arabian countries. The purpose of the registry was to gather data on this mechanical circulatory support treatment from many sites in order to evaluate its efficacy and outcome 1,[9][10][11][12][13][14][15][16][17] . Each participating center collected data and entered them into a Microsoft® Access database.…”

Section: The Pc-ecmo Study Cohortmentioning

confidence: 99%

Postcardiotomy Venoarterial Extracorporeal Membrane Oxygenation With and Without Intra-Aortic Balloon Pump

Björnsdóttir

Biancari

Dalén

et al. 2022

Journal of Cardiothoracic and Vascular Anesthesia

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Outcome of Repeat Venoarterial Extracorporeal Membrane Oxygenation in Postcardiotomy Cardiogenic Shock

Cited by 2 publications

References 16 publications

Impact of Repeat Extracorporeal Life Support on Mortality and Short-term In-hospital Morbidities in Neonates With Congenital Diaphragmatic Hernia

Impact of Repeat Extracorporeal Life Support on Mortality and Short-term In-hospital Morbidities in Neonates With Congenital Diaphragmatic Hernia

Postcardiotomy Venoarterial Extracorporeal Membrane Oxygenation With and Without Intra-Aortic Balloon Pump

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