Nanocomposite sponges for enhancing intestinal residence time following oral administration

Rosso, Annalisa; Andretto, Valentina; Chevalier, Yves; Kryza, David; Sidi-Boumedine, Jacqueline; Grenha, Ana; Guerreiro, Filipa; Gharsallaoui, Adem; Padula, Veronica La; Montembault, Alexandra; David, Laurent; Briançon, Stéphanie; Lollo, Giovanna

doi:10.1016/j.jconrel.2021.04.004

Cited by 21 publications

(22 citation statements)

References 65 publications

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“…Wang et al [ 128 ] used chitosan nanoparticles to deliver metformin for the treatment of polycystic kidney disease and found a 1.3-fold increase in AUC when compared to free drug. Rosso et al [ 129 ] used chitosan-based nanocomposite sponges to prolong residence time and found that the released drug was present for at least 6 h in the cecum (compared to 3 h for non-encapsulated drug). Shin et al [ 130 ] investigated chitosan and oligochitosan-based coatings for curcumin nanosuspensions, and found a three to fourfold increase in mucoadhesion when compared to uncoated nanosuspensions.…”

Section: Mucoadhesive Drug Delivery Systemsmentioning

confidence: 99%

Mucus interaction to improve gastrointestinal retention and pharmacokinetics of orally administered nano-drug delivery systems

2022

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Oral delivery of therapeutics is the preferred route of administration due to ease of administration which is associated with greater patient medication adherence. One major barrier to oral delivery and intestinal absorption is rapid clearance of the drug and the drug delivery system from the gastrointestinal (GI) tract. To address this issue, researchers have investigated using GI mucus to help maximize the pharmacokinetics of the therapeutic; while mucus can act as a barrier to effective oral delivery, it can also be used as an anchoring mechanism to improve intestinal residence. Nano-drug delivery systems that use materials which can interact with the mucus layers in the GI tract can enable longer residence time, improving the efficacy of oral drug delivery. This review examines the properties and function of mucus in the GI tract, as well as diseases that alter mucus. Three broad classes of mucus-interacting systems are discussed: mucoadhesive, mucus-penetrating, and mucolytic drug delivery systems. For each class of system, the basis for mucus interaction is presented, and examples of materials that inform the development of these systems are discussed and reviewed. Finally, a list of FDA-approved mucoadhesive, mucus-penetrating, and mucolytic drug delivery systems is reviewed. In summary, this review highlights the progress made in developing mucus-interacting systems, both at a research-scale and commercial-scale level, and describes the theoretical basis for each type of system.

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Section: Mucoadhesive Drug Delivery Systemsmentioning

confidence: 99%

Mucus interaction to improve gastrointestinal retention and pharmacokinetics of orally administered nano-drug delivery systems

2022

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“…The oral C max of methotrexate was 81.72 ± 23.01 (ng/mL) for methotrexate-loaded NE, 12.13 ± 3.38 (ng/mL) for free methotrexate, which was due to methotrexate-loaded NE being absorbed into lymphatic vessel [109]. NE-loaded CS sponges with two merits in-cluding improving intestinal mucoadhesive properties and drugs permeability might have potential for orally delivering drugs [110]. In addition to making use of its own merits, application of inhibitors to prepare NE is an advisable method for improving drugs absorption.…”

Section: Nanoemulsion and Self-emulsified Drug Delivery Systemsmentioning

confidence: 98%

“…Pharmaceutics 2022, 14, x FOR PEER REVIEW 13 of 20 improving intestinal mucoadhesive properties and drugs permeability might have potential for orally delivering drugs [110]. In addition to making use of its own merits, application of inhibitors to prepare NE is an advisable method for improving drugs absorption.…”

Section: Nanoemulsion and Self-emulsified Drug Delivery Systemsmentioning

confidence: 99%

Strategies and Mechanism in Reversing Intestinal Drug Efflux in Oral Drug Delivery

Lü

Zhou

et al. 2022

Pharmaceutics

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Efflux transporters distributed at the apical side of human intestinal epithelial cells actively transport drugs from the enterocytes to the intestinal lumen, which could lead to extremely poor absorption of drugs by oral administration. Typical intestinal efflux transporters involved in oral drug absorption process mainly include P-glycoprotein (P-gp), multidrug resistance proteins (MRPs) and breast cancer resistance protein (BCRP). Drug efflux is one of the most important factors resulting in poor absorption of oral drugs. Caco-2 monolayer and everted gut sac are sued to accurately measure drug efflux in vitro. To reverse intestinal drug efflux and improve absorption of oral drugs, a great deal of functional amphiphilic excipients and inhibitors with the function of suppressing efflux transporters activity are generalized in this review. In addition, different strategies of reducing intestinal drugs efflux such as silencing transporters and the application of excipients and inhibitors are introduced. Ultimately, various nano-formulations of improving oral drug absorption by inhibiting intestinal drug efflux are discussed. In conclusion, this review has significant reference for overcoming intestinal drug efflux and improving oral drug absorption.

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“…Nanoemulsions (NEs) were prepared by emulsion phase inversion technique coupled with high stirring energy input as previously described [4]. Brie y, NEs composed of an oil core of medium chain triglycerides (MCT) were stabilized by a shell of surfactants, made of a mixing of polyoxyethylene (40) stearate (Myrj®52) and oleoyl polyoxyl-6 glycerides (Labra l®M1944CS), hydrophilic and hydrophobic surfactants, respectively.…”

Section: Preparation Of Curcumin-loaded Nanoemulsionsmentioning

confidence: 99%

Alginate-pectin microparticles loaded with nanoemulsions as nanocomposites for wound healing

Amante

Andretto

Rosso

et al. 2022

Preprint

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This work combines natural polymers with nanoemulsions (NEs) to formulate nanocomposites as innovative wound dressing. Spray drying has been used to produce alginate-pectin in situ gelling powders as carriers for NEs loaded with curcumin (CCM), a model antimicrobial drug. The influence of NEs encapsulation in polymer-based microparticles was studied in terms of particle size distribution, morphology, and stability after spray drying. NEs loading did not affect the size of microparticles which was around 3.5 µm, while the shape and surface morphology analyzed using scanning electron microscope (SEM), changed from irregular to spherical. Nanocomposites as dried powders were able to form a gel in less than 5 minutes when in contact with simulated wound fluid (SWF), while the value of moisture transmission of the in situ formed hydrogels allowed to promote good wound transpiration. Moreover, rheologic analyses showed that in situ formed gels loaded with NEs appeared more elastic than blank formulations. The in situ formed gel allowed the prolonged release of CCM-loaded NEs in the wound bed, reaching 100% in 24 hours. Finally, powders cytocompatibility was confirmed by incubation with keratinocyte cells (HaCaT), proving that such nanocomposites can be considered a potential candidate for wound dressings.

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Nanocomposite sponges for enhancing intestinal residence time following oral administration

Cited by 21 publications

References 65 publications

Mucus interaction to improve gastrointestinal retention and pharmacokinetics of orally administered nano-drug delivery systems

Mucus interaction to improve gastrointestinal retention and pharmacokinetics of orally administered nano-drug delivery systems

Strategies and Mechanism in Reversing Intestinal Drug Efflux in Oral Drug Delivery

Alginate-pectin microparticles loaded with nanoemulsions as nanocomposites for wound healing

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