Neural correlates of visuospatial processing in migraine: does the pain network help?

Messina, Roberta; Meani, Alessandro; Riccitelli, Gianna Carla; Colombo, Bruno; Filippi, Massimo; Rocca, Maria A.

doi:10.1038/s41380-021-01085-2

Cited by 11 publications

(17 citation statements)

References 41 publications

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“…Here, we found that microgliosis, astrogliosis and neuronal loss were present in the cerebral cortex and hippocampus following dural IS stimulation (Fig. 4 ), which may account for the structural and functional alterations in the cerebral cortex and hippocampus of migraine patients previously observed in clinical neuroimaging studies [ 5 , 31 ]. These pathological changes were attenuated by pretreatment with BBG (Figs.…”

Section: Discussionsupporting

confidence: 62%

“…However, the role of P2X7R in migraine-related cognitive impairment has not been disclosed. Migraineurs frequently exhibited structural and functional abnormalities in the cerebral cortex and hippocampus, which is one of the possible mechanisms accounting for cognitive decline in migraineurs [ 5 , 31 ]. In the present study, we observed the elevated expression level of P2X7R in cerebral cortex and hippocampus, brain regions related to cognition, following repeated dural IS stimulation (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…It has been shown that the spatial learning ability in the Morris water maze critically depends on hippocampal function [ 54 ], while the recognition memory in novel object recognition test mainly relies on limbic-cortical function [ 55 ]. A recent clinical study reported that the impaired visuospatial processing of migraine patients was associated with abnormal recruitment of cortical areas including the anterior insula, medial frontal and orbitofrontal cortex [ 5 ], demonstrating a key role of cortical areas in migraine-related cognitive deficits. However, these cognitive behavioral results were in contrast with a previous study conducted on a genetic mouse model of familial hemiplegic migraine type 1 (FHM-1) [ 56 ].…”

Section: Discussionmentioning

confidence: 99%

“…Evidence from clinical studies showed that cognitive symptoms of migraineurs may be associated with the structural and functional abnormalities in the cerebral cortex, hippocampus and white matter [ 5 , 31 , 32 ]. It has been shown that inflammasome activation can mediate cognitive decline in a mouse model of VaD by inducing gliosis, neuronal loss in the cerebral cortex and hippocampus, and white matter damage [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

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P2X7R/NLRP3 signaling pathway-mediated pyroptosis and neuroinflammation contributed to cognitive impairment in a mouse model of migraine

et al. 2022

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Migraine is the second most common form of headache disorder and the second leading cause of disability worldwide. Cognitive symptoms ranked second resulting in migraine-related disability, after pain. P2X7 receptor (P2X7R) was recently shown to be involved in hyperalgesia in migraine. However, the role of P2X7R in migraine-related cognitive impairment is still ill-defined. The aim of this study was to explore the molecular mechanisms underlying migraine-related cognitive impairment and the role of P2X7R in it. Here we used a well-established mouse model of migraine that triggered migraine attacks by application of inflammatory soup (IS) to the dura. Our results showed that repeated dural IS stimulation triggered upregulation of P2X7R, activation of NLRP3 inflammasome, release of proinflammatory cytokines (IL-1β and IL-18) and activation of pyroptotic cell death pathway. Gliosis (microgliosis and astrogliosis), neuronal loss and cognitive impairment also occurred in the IS-induced migraine model. No significant apoptosis or whiter matter damage was observed following IS-induced migraine attacks. These pathological changes occurred mainly in the cerebral cortex and to a less extent in the hippocampus, all of which can be prevented by pretreatment with a specific P2X7R antagonist Brilliant Blue G (BBG). Moreover, BBG can alleviate cognitive impairment following dural IS stimulation. These results identified P2X7R as a key contributor to migraine-related cognitive impairment and may represent a potential therapeutic target for mitigating cognitive impairment in migraine.

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Section: Discussionsupporting

confidence: 62%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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P2X7R/NLRP3 signaling pathway-mediated pyroptosis and neuroinflammation contributed to cognitive impairment in a mouse model of migraine

et al. 2022

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“…Interestingly, the pain networks trigger an adaptive visual networks functional plasticity that might help migraine patients to overcome impaired visuospatial skills. 25 These suggest that the interaction between the visual networks and the pain networks is strong in migraine. In order to better understand the pathological mechanism of visual network abnormalities in CM, we should investigate the correlation between visual networks and pain networks.…”

Section: Discussionmentioning

confidence: 99%

MRI Evaluation of the Relationship Between Abnormalities in Vision-Related Brain Networks and Quality of Life in Patients with Migraine without Aura

Cui¹,

Zhang²,

Xu³

et al. 2021

NDT

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Objective To evaluate whether migraine without aura (MwoA) can be partly attributed to abnormalities of vision-related brain networks (VBN) and whether these specific regional abnormalities affect the patients’ quality of life (QoL). Methods A total of 40 participants, including 20 MwoA patients and 20 healthy control volunteers, were enrolled. There were no significant differences in sex, age, educational qualifications and dominant hand between the two groups. Headache intensity and QoL were assessed by the Pain Number Evaluation Scale (NRS) and the Migraine-Specific Quality of Life Questionnaire (MSQ 2.1), respectively. Resting state functional magnetic resonance imaging (rs-fMRI) and independent component analysis (ICA) were performed to determine and evaluate the VBN. Results Three components were identified as consistent with the VBN in the template and recorded as N1, N2 and N3, respectively. The functional activity of the left primary visual cortex (N1), left culmen of cerebellum (N1), left lingual gyrus (N2), superior frontal gyrus (N2) and left posterior lateral prefrontal cortex (N3) in the MwoA group enhanced compared with the healthy control group. However, the functional activity of right middle occipital gyrus, left fusiform gyrus, right lingual gyrus, and right primary motor cortex in the N3 network weakened. Pearson correlation analysis showed that decline of attention to work and life (MSQ5) was positively associated with the functional activity of left primary visual cortex and left lingual gyrus. Canceling from work and daily life (MSQ8) was inversely associated with the functional activity of right primary motor cortex. The burden of feeling like others (MSQ13) and the overall decrease in QoL were both positively associated with the functional activity of right lingual gyrus. Conclusion MwoA patients showed abnormal VBN function, which was moderately correlated with decreased QoL. This study provides evidence for the precise prevention and treatment of migraine by neural regulation.

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In search of a neuropsychological profile for migraine: A scoping review

Richardson,

Diaz‐Orueta

2024

European Journal of Pain

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ObjectiveMigraine is commonly overlooked by the general population and by professionals in research and clinical practice. Moreover, it is difficult to grasp the neuropsychological profile of migraineurs due to the cyclic nature of the disorder. With this in mind, a scoping review of the literature was conducted with the goal of characterizing cognitive domains associated with deficits in migraine.MethodsPubMed, PsychInfo, Scopus, EMBASE and OpenGrey databases were searched for studies published from 1st January 2006 to 30th November 2022. Following the review process, 52 eligible studies were included in the review.ResultsStudies included in this review show mixed and sometimes contradictory findings. Overall, both visual and auditory perception appear to be impaired. Deficits on attention, many memory processes, visuospatial function and spatial navigation and on a wide range of executive functions (set‐shifting and cognitive flexibility, decision‐making and reasoning, working memory and prospective memory) complete a complex cognitive profile in migraine. Lack of consistency across studies in sample selection and sizes, lack of detailed links between cognitive deficits and specific migraine phases, or length and chronicity, inconsistencies on the role of aura in cognitive function; and heterogeneity and sometimes questionable reliability and validity of some of the cognitive measures used may affect the clarity and consistency of results observed.ConclusionFurther research properly addressing the role of gender and age, migraine stage, length and chronicity of the condition, the effect of aura and comorbidities is needed, alongside increasing consistency across diverse neuropsychological assessment protocols.SignificanceThis review provides a comprehensive, up‐to‐date picture of the current status of knowledge in relation to the characterization of the complex cognitive profile of migraine. It offers detailed information of the existing research gaps and challenges to improve the cognitive characterization of migraine across its different stages and leads clinicians to carefully consider the selection of relevant cognitive tasks, in order to grasp more accurately the patient’s cognitive profile; an assessment that should be an integral part of any protocol developed for the clinical assessment and subsequent treatment planning for migraine.

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Neural correlates of visuospatial processing in migraine: does the pain network help?

Cited by 11 publications

References 41 publications

P2X7R/NLRP3 signaling pathway-mediated pyroptosis and neuroinflammation contributed to cognitive impairment in a mouse model of migraine

P2X7R/NLRP3 signaling pathway-mediated pyroptosis and neuroinflammation contributed to cognitive impairment in a mouse model of migraine

MRI Evaluation of the Relationship Between Abnormalities in Vision-Related Brain Networks and Quality of Life in Patients with Migraine without Aura

In search of a neuropsychological profile for migraine: A scoping review

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