Charcot-Leyden crystals in chronic eosinophilic leukemia

Sandberg, Yorick; Weerkamp, Floor

doi:10.1182/blood.2020010648

Cited by 3 publications

(1 citation statement)

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“…The potential of galectin-10 as a biomarker includes its evaluation in myeloproliferative diseases. CLCs have been reported in the tissue and bone marrow from patients with hypereosinophilic syndrome, including eosinophilic leukemia [ 70 , 106 , 107 , 108 , 109 , 110 ]. Indeed, CLCs were originally identified in the cardiac blood and spleen in patients who died from leukemia [ 111 ].…”

Section: Myeloproliferative Diseases and Clcsmentioning

confidence: 99%

Galectin-10 as a Potential Biomarker for Eosinophilic Diseases

et al. 2022

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Galectin-10 is a member of the lectin family and one of the most abundant cytoplasmic proteins in human eosinophils. Except for some myeloid leukemia cells, basophils, and minor T cell populations, galectin-10 is exclusively present in eosinophils in the human body. Galectin-10 forms Charcot–Leyden crystals, which are observed in various eosinophilic diseases. Accumulating studies have indicated that galectin-10 acts as a new biomarker for disease activity, diagnosis, and treatment effectiveness in asthma, eosinophilic esophagitis, rhinitis, sinusitis, atopic dermatitis, and eosinophilic granulomatosis with polyangiitis. The extracellular release of galectin-10 is not mediated through conventional secretory processes (piecemeal degranulation or exocytosis), but rather by extracellular trap cell death (ETosis), which is an active cell death program. Eosinophils undergoing ETosis rapidly disintegrate their plasma membranes to release the majority of galectin-10. Therefore, elevated galectin-10 levels in serum and tissue suggest a high degree of eosinophil ETosis. To date, several studies have shown that galectin-10/Charcot–Leyden crystals are more than just markers for eosinophilic inflammation, but play functional roles in immunity. In this review, we focus on the close relationship between eosinophils and galectin-10, highlighting this protein as a potential new biomarker in eosinophilic diseases.

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