DNA methylation of tumour necrosis factor (TNF) alpha gene is associated with specific blood fatty acid levels in a gender‐specific manner

Hussey, Bethan; Steel, Richard; Gyimah, Boakye; Reynolds, James C.; Taylor, Ian; Lindley, Martin R.; Mastana, Sarabjit S.

doi:10.1002/mgg3.1679

Cited by 5 publications

(3 citation statements)

References 57 publications

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“…The 7,10,13,16-cis-docosatetraenoic acid, an ω-6 PUFA, was elevated in both female offspring ovaries and male offspring testes in response to an HFD. The 7,10,13,16-cis-docosatetraenoic acid plays an important role in inflammatory mediation by acting as a ligand for immune receptors and triggering increased TNFα levels [32]. In our study, female offspring fed with a postnatal HFD increased TNFα expression only when they were born to GDM mother.…”

Section: Discussionsupporting

confidence: 44%

Rodents on a high-fat diet born to mothers with gestational diabetes exhibit sex-specific lipidomic changes in reproductive organs

Wang¹,

Luo²,

Chen³

et al. 2022

ABBS

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Maternal gestatonal diabetes mellitus (GDM) and offspring high-fat diet (HFD) have been shown to have sex-specific detrimental effects on the health of the offspring. Maternal GDM combined with an offspring HFD alters the lipidomic profiles of offspring reproductive organs with sex hormones and increases insulin signaling, resulting in offspring obesity and diabetes. The pre-pregnancy maternal GDM mice model is established by feeding maternal C57BL/6 mice and their offspring are fed with either a HFD or a low-fat diet (LFD). Testis, ovary and liver are collected from offspring at 20 weeks of age. The lipidomic profiles of the testis and ovary are characterized using gas chromatography-mass spectrometry. Male offspring following a HFD have elevated body weight. In reproductive organs and hormones, male offspring from GDM mothers have decreased testes weights and testosterone levels, while female offspring from GDM mothers show increased ovary weights and estrogen levels. Maternal GDM aggravates the effects of an offspring HFD in male offspring on the AKT pathway, while increasing the risk of developing inflammation when expose to a HFD in female offspring liver. Testes are prone to the effect of maternal GDM, whereas ovarian metabolite profiles are upregulated in maternal GDM and downregulated in offspring following an HFD. Maternal GDM and an offspring HFD have different metabolic effects on offspring reproductive organs, and PUFAs may protect against detrimental outcomes in the offspring, such as obesity and diabetes.

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Section: Discussionsupporting

confidence: 44%

Rodents on a high-fat diet born to mothers with gestational diabetes exhibit sex-specific lipidomic changes in reproductive organs

Wang¹,

Luo²,

Chen³

et al. 2022

ABBS

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“…29 , 30 Interestingly, polyunsaturated fatty acids, generally regarded as a feature of rather healthy foods, may be involved in DNA methylation procedures as well. 28 , 37 Their role in this context is hitherto incompletely understood, however, as different effects have been noted depending on sex 37 or even cell type. 28 Hence, caution should be used when applying the present data to dietary counselling as of yet.…”

Section: Discussionmentioning

confidence: 99%

Methyl donor micronutrients, CD40-ligand methylation and disease activity in systemic lupus erythematosus: A cross-sectional association study

Vordenbäumen

Sokolowski

Rosenbaum

et al. 2021

Lupus

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Objective Hypomethylation of CD40-ligand (CD40L) in T-cells is associated with increased disease activity in systemic lupus erythematosus (SLE). We therefore investigated possible associations of dietary methyl donors and products with CD40L methylation status in SLE. Methods Food frequency questionnaires were employed to calculate methyl donor micronutrients in 61 female SLE patients (age 45.7 ± 12.0 years, disease duration 16.2 ± 8.4 years) and compared to methylation levels of previously identified key DNA methylation sites (CpG17 and CpG22) within CD40L promotor of T-cells using quantitative DNA methylation analysis on the EpiTYPER mass spectrometry platform. Disease activity was assessed by SLE Disease Activity Index (SLEDAI). Linear regression modelling was used. P values were adjusted according to Benjamini & Hochberg. Results Amongst the micronutrients assessed (g per day), methionine and cysteine were associated with methylation of CpG17 (β = 5.0 (95%CI: 0.6-9.4), p = 0.04; and β = 2.4 (0.6-4.1), p = 0.02, respectively). Methionine, choline, and cysteine were additionally associated with the mean methylation of the entire CD40L (β = 9.5 (1.0-18.0), p = 0.04; β = 1.6 (0.4-3.0), p = 0.04; and β = 4.3 (0.9-7.7), p = 0.02, respectively). Associations of the SLEDAI with hypomethylation were confirmed for CpG17 (β=-32.6 (-60.6 to -4.6), p = 0.04) and CpG22 (β=-38.3 (-61.2 to -15.4), p = 0.004), but not the mean methylation of CD40L. Dietary products with the highest impact on methylation included meat, ice cream, white bread, and cooked potatoes. Conclusions Dietary methyl donors may influence DNA methylation levels and thereby disease activity in SLE.

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“…[ 101 ] Methylation levels of TNFexon 1 showed a significant correlation with specific fatty acids in a gender‐specific manner suggesting that one way that fatty acids interact with the inflammation is through altered methylation profiles of cytokine genes. [ 102 ] Another DNA methylation example related to inflammation is observed in Helicobacter pylori infection. Helicobacter pylori infection of epithelial cells is associated with the activation of several intracellular pathways.…”

Section: The Interplay Between Epigenetics and Immunometabolic Disordersmentioning

confidence: 99%

Epigenetic Network in Immunometabolic Disease

Geiger,

Gorica,

Mohammed

et al. 2023

Advanced Biology

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Although a large amount of data consistently shows that genes affect immunometabolic characteristics and outcomes, epigenetic mechanisms are also heavily implicated. Epigenetic changes, including DNA methylation, histone modification, and noncoding RNA, determine gene activity by altering the accessibility of chromatin to transcription factors. Various factors influence these alterations, including genetics, lifestyle, and environmental cues. Moreover, acquired epigenetic signals can be transmitted across generations, thus contributing to early disease traits in the offspring. A closer investigation is critical in this aspect as it can help to understand the underlying molecular mechanisms further and gain insights into potential therapeutic targets for preventing and treating diseases arising from immuno‐metabolic dysregulation. In this review, the role of chromatin alterations in the transcriptional modulation of genes involved in insulin resistance, systemic inflammation, macrophage polarization, endothelial dysfunction, metabolic cardiomyopathy, and nonalcoholic fatty liver disease (NAFLD), is discussed. An overview of emerging chromatin‐modifying drugs and the importance of the individual epigenetic profile for personalized therapeutic approaches in patients with immuno‐metabolic disorders is also presented.

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DNA methylation of tumour necrosis factor (TNF) alpha gene is associated with specific blood fatty acid levels in a gender‐specific manner

Cited by 5 publications

References 57 publications

Rodents on a high-fat diet born to mothers with gestational diabetes exhibit sex-specific lipidomic changes in reproductive organs

Rodents on a high-fat diet born to mothers with gestational diabetes exhibit sex-specific lipidomic changes in reproductive organs

Methyl donor micronutrients, CD40-ligand methylation and disease activity in systemic lupus erythematosus: A cross-sectional association study

Epigenetic Network in Immunometabolic Disease

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