Epidemiology and in vitro antimicrobial susceptibility of aerobic Actinomycetales in a clinical setting

Salar-Vidal, Llanos; Martín-García, Marta; Macías-Valcayo, Alicia; Ponz, Ana; Esteban, Jaime

doi:10.1016/j.eimc.2021.02.010

Cited by 2 publications

(2 citation statements)

References 16 publications

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“…The combination of abscess evacuation by craniotomy and administration of antibiotics, being cotrimoxazole the drug of choice, gives very good results for patients with Nocardia brain abscess. However, antibiotics must be adjusted according to the sensitivity profiles tested [8], even though a high susceptibility of Nocardia farcinica to cotrimoxazole, amikacin, and linezolid has been reported in Spain [4], resistance to cotrimoxazole close to 54% has been documented in other countries [9]. ent cavities and partial excision of the capsule.…”

Section: Sirmentioning

confidence: 99%

“…The isolate was identified with a high degree of confidence (score = 2.1) using MALDI-TOF technology (Bruker®) as Nocardia farcinica . Approximately 75% of N. farcinica isolates may be resistant to third-generation cephalosporins [ 4 ], so intravenous treatment with cotrimoxazole 800/160mg/8h and amikacin 1g/24h was decided until the sensitivity study was obtained. antibiotic.…”

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confidence: 99%

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Cerebellious abscesses caused by Nocardia farcinica in an immunocompromised patient

Ramos¹,

Vega-Torres²,

Irles-Vidal³

et al. 2022

Rev Esp Quimioter

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Section: Sirmentioning

confidence: 99%

mentioning

confidence: 99%

Cerebellious abscesses caused by Nocardia farcinica in an immunocompromised patient

Ramos¹,

Vega-Torres²,

Irles-Vidal³

et al. 2022

Rev Esp Quimioter

View full text Add to dashboard Cite

High Rates of Antimicrobial Resistance in Rapidly Growing Mycobacterial Infections in Taiwan

Lee

Chen

et al. 2022

Pathogens

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Rapidly growing mycobacteria (RGM) has gained increasing clinical importance, and treatment is challenging due to diverse drug resistance. The minimum inhibitory concentrations (MIC) of 13 antimicrobial agents using modified broth microdilution and E-test were determined for 32 clinical isolates of RGM, including Mycobacterium abscessus (22 isolates) and Mycobacterium fortuitum (10 isolates). Our results showed high rates of resistance to available antimicrobial agents. Amikacin remained highly susceptible (87.5%). Clarithromycin was active against the isolates of M. abscessus (95.5%), and M. fortuitum (50%), but 36.4% and 20% had inducible macrolide resistance, respectively. Rates of susceptibility to tigecycline were 68.2–70%, and linezolid 45.5–50%, respectively. The quinolones (ciprofloxacin and moxifloxacin) showed better in vitro activity against M. fortuitum isolates (50% susceptibility) than the M. abscessus isolates (31.8% susceptibility). The susceptibilities to other conventional anti-mycobacterial agents were poor. The MICs of E-test were higher than broth microdilution and may result in reports of false resistance. In conclusion, the implementation of the modified broth microdilution plates into the routine clinical laboratory workflow to provide antimicrobial susceptibility early, allows for the timely selection of appropriate treatment of RGM infections to improve outcome.

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Epidemiology and in vitro antimicrobial susceptibility of aerobic Actinomycetales in a clinical setting

Cited by 2 publications

References 16 publications

Cerebellious abscesses caused by Nocardia farcinica in an immunocompromised patient

Cerebellious abscesses caused by Nocardia farcinica in an immunocompromised patient

High Rates of Antimicrobial Resistance in Rapidly Growing Mycobacterial Infections in Taiwan

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