Supplementation of the BIOXcell extender with the antioxidants crocin, curcumin and GSH for freezing bull semen

Salman, Amer; Caamaño, J. N.; Fernández‐Alegre, Estela; Hidalgo, C.O.; Nadri, Touba; Tamargo, Carolina; Fueyo, Carmen; Fernández, A Víctor; Merino, María José; Martínez‐Pastor, Felipe

doi:10.1016/j.rvsc.2021.03.025

Cited by 10 publications

(13 citation statements)

References 43 publications

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“…The results presented here suggest that spermatozoa cryopreserved in the presence of 1 mM of crocin exhibited better progressive and rapid motility than control cells, at the end of 2‐hr incubation at 37°C. Similar results were obtained in the ram (Rodríguez‐Gutiérrez et al., 2020), but not in bovine spermatozoa (Salman et al., 2021). The observed discrepancies with the last study could be attributed to the different experimental setup.…”

Section: Discussionsupporting

confidence: 76%

“…On the contrary, a recent study by Salman et al. (2021) reported that the supplementation of the freezing extender with crocin (0.5 and 1.5 mM) decreased viability and increased apoptotic features in bovine spermatozoa.…”

Section: Introductionmentioning

confidence: 87%

“…Moreover, crocin has been supplemented in different concentrations in the freezing extender medium in rooster (0.5, 1, 1.5 mM), ram (1 mM) and goat (1 mM) semen with promising results (Longobardi et al, 2020;Mehdipour et al, 2020;Rodríguez-Gutiérrez et al, 2020). On the contrary, a recent study by Salman et al (2021) reported that the supplementation of the freezing extender with crocin (0.5 and 1.5 mM) decreased viability and increased apoptotic features in bovine spermatozoa.…”

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confidence: 84%

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The addition of crocin in the freezing medium extender improves post‐thaw semen quality

Sapanidou

Lavrentiadou

Errico³

et al. 2021

Reprod Domestic Animals

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Semen cryopreservation is arguably the most important method or technique contributing to the advancement of modern animal production. However, the quality of sperm after thawing is still highly variable. The addition of antioxidant compounds to the freezing medium has been used customarily to counteract the harmful effects of Reactive Oxygen Species (ROS) that are produced during the freeze/thaw process.Crocin, a potent antioxidant, improves the fertilizing capacity of spermatozoa. In this study, we evaluated the potential of crocin (0, 0.5 and 1 mM) as an extender additive to diminish the damaging effects of cryopreservation on bovine spermatozoa. Postthaw semen quality was assessed by means of motility, viability and lipid peroxidation (LPO). We further investigated the effect of crocin supplementation upon freezing on sperm quality parameters during their incubation at 37°C for up to 2 hr. Overall, the

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Section: Discussionsupporting

confidence: 76%

Section: Introductionmentioning

confidence: 87%

mentioning

confidence: 84%

See 1 more Smart Citation

The addition of crocin in the freezing medium extender improves post‐thaw semen quality

Sapanidou

Lavrentiadou

Errico³

et al. 2021

Reprod Domestic Animals

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“…Bucak et al showed that in comparison with control, a 0.5 mM dose of CUR added into bull semen extender led to lower percentage of total abnormality, provided a greater protective effect in the membrane functional integrity and higher levels of the maintenance of total glutathione, while it did not significantly affect the lipid peroxidation and antioxidant potential levels, indicating that antioxidants addition prior to the cryopreservation process might be a recommended strategy to facilitate sperm cryopreservation. Another study has shown that after pretreatment with CUR, sperm movement, vitality, and energy have no significant effects in the frozen semen of the Holshtean bulls, but the ROS content in sperm cytoplasm was significantly reduced, which thus reduced the damage caused by ROS to sperm [ 89 ]. These above results deepened our understanding of the biological role and health benefits of CUR and their new potential application in poultry and livestock nutrition ( Table 4 ).…”

Section: Resultsmentioning

confidence: 99%

Current Development and Future Application Prospects of Plants-Derived Polyphenol Bioactive Substance Curcumin as a Novel Feed Additive in Livestock and Poultry

Pan

Yan

Chen

et al. 2022

IJMS

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Curcumin (CUR) is a kind of natural orange-yellow phenolic compound mainly extracted from the stems and roots of turmeric plants and other species in the genus Curcuma, furthermore, it is also the most important active ingredient exerting pharmacological functions in turmeric. In recent years, CUR has been frequently reported and has attracted widespread attention from scholars all over the world due to its numerous biological functions and good application prospects, such as anti-inflammatory, anticancer, antioxidant and providing lipid-lowering effects, etc. In addition, adding a certain dose of CUR to livestock and poultry feed is important for animal growth and development, which plays a key role in animal metabolism, reproduction, immunity and clinical health care. This review aims to summarize, based on the published papers and our own observations, the physical and chemical properties and the biological functions of the plant-derived bioactive ingredient CUR, especially regarding the latest research progress in regulating intestinal health as well as its current development and future application prospects in livestock and poultry as a novel feed additive, so as to provide theoretical and practical references for the further study of the application of CUR as a novel feed additive and a potential new antibiotic substitute, thereby improving the research field of plant-derived bioactive ingredients and promoting the healthy development of livestock and poultry.

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“…Neste grupo foi observada ainda correlação positiva de GSSG com maior suscetibilidade à peroxidação lipídica e fragmentação de DNA. Quanto à raça Nelore, não foram observam que a adição de GSH, em doses corretas, é capaz de reestabelecer a homeostase oxidativa, reduzindo danos à membrana plasmática, fragmentação de DNA e iniciação de processos de apoptose, no entanto, demonstram ainda que o excesso de GSH pode causar efeitos deletérios, até mesmo por ação pró-oxidativa (MESEGUER,MARTÍNEZ-CONEJERO, et al, 2007; SHAH, SINGH, et al, 2017; GAUCHER, BOUDIER, et al, 2018; NADRI, TOWHIDI, et al, 2020;SALMAN, estabelecer se a maior concentração de GSH poderia ter um efeito pró-oxidativo no grupo Angus de baixa fertilidade (MESEGUER,MARTÍNEZ-CONEJERO, et al, 2007; GAUCHER, BOUDIER, et al, 2018; SALMAN, CAAMAÑO, et al, 2021).…”

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>b<Análise lipidômica, metabolômica e dos atributos espermáticos de touros com diferentes taxas de fertilidade e perfis de congelação de sêmen>/b<

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Dedico este trabalho à minha família. Ao meu avô que dividiu comigo o seu amor pelos estudos, não apenas da veterinária, mas de tudo que despertasse minha curiosidade. Ao meu pai que, com muito amor, me ensinou a seguir sonhos e alcançar realizações. À minha mãe e ao Reche, que sempre me apoiaram, especialmente nessa nova jornada, com amor e força constantes.Dedico também aos meus mestres, que por ensinamentos e exemplos estão ao meu lado desde o início da minha caminhada, e aos amigos queridos que participaram e me ajudaram muito nessa nova trajetória da minha vida. "Still round the corner there may wait A new road or a secret gate And though I often have passed them by A day will come at last when I Shall take the hidden paths that run West of the Moon, East of the Sun." A Walking Song -The Lord of the Rings (1954) J.R.R. Tolkien AGRADECIMENTOS Muito a agradecer por esses últimos anos, principalmente por ter voltado ao lugar que me proporcionou anos maravilhosos na vida, a FMVZ-USP. Volta que permitiu, mais uma vez, que eu ganhasse não apenas conhecimento, mas experiências, convivências e amizades, com grande crescimento pessoal. Essa nova caminhada, não seria possível sem o apoio constante do meu grande amor. Obrigada Reche por ter sido sempre o melhor companheiro, ter aguentado os momentos de estresse, comemorado as conquistas, lido e corrigido textos e, além de tudo, por ter me alimentado, com o grande estilo do "Chef Medrano", nos meses em que eu fiquei analisando dados, escrevendo e estudando.Gratidão infinita à minha mãe, por estar sempre ao meu lado, me apoiando com amor, pela preocupação e por me lembrar sempre de ter paciência e esperança.Rodrigo, Flávia, Dani e Zeca, muito obrigada por trazerem sempre mais amor e alegria à minha vida.Desde que entrei na pós-graduação, tive a sorte de encontrar amigos para a vida. Kelly querida, que hoje é como uma irmã, obrigada por toda a ajuda, ensinamentos, conversas e desabafos, desde o início. Kelly, May e Karine, mulheres da ciência, amigas, irmãs, exemplos, obrigada por tudo! De volta à FMVZ pude conviver em família, especialmente no VRA, com muito trabalho, mas sem deixar de lado a diversão, com muitas risadas, churrascos, cantorias a danças. Devo muito a quem me deu a oportunidade de voltar, Prof.Marcílio. Muito obrigada por abrir as portas do VRA e do Laboratório de Andrologia (LA), pela confiança, apoio, carinho, por todos os ensinamentos e oportunidades de aprendizado com as várias colaborações. Muita alegria e orgulho de ter a sua orientação nesse trabalho! E o que falar do time nota mil do LA! Obrigada Diego pelos ensinamentos, parceria e amizade. Como o Reche fala, "cuida bem do Di", e é isso que sempre farei, pois é um amigo querido e estou sempre na torcida para que tenha um futuro brilhante. Obrigada Giu, por estar ao meu lado nos primeiros passos nas análises do LA, mas mais que tudo, por me fazer encarar o microfone para cantar sofrência, algo que quem não viu, jamais acreditará. Obrigada Ken, Alvinho, Rapha, Henrique, Mônica, Bia e Duda, pela ajud...

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Supplementation of the BIOXcell extender with the antioxidants crocin, curcumin and GSH for freezing bull semen

Cited by 10 publications

References 43 publications

The addition of crocin in the freezing medium extender improves post‐thaw semen quality

The addition of crocin in the freezing medium extender improves post‐thaw semen quality

Current Development and Future Application Prospects of Plants-Derived Polyphenol Bioactive Substance Curcumin as a Novel Feed Additive in Livestock and Poultry

>b<Análise lipidômica, metabolômica e dos atributos espermáticos de touros com diferentes taxas de fertilidade e perfis de congelação de sêmen>/b<

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