“…Of note, bilateral orchidectomy did not affect the rescue of olfaction or recognition memory by pulsatile GnRH, suggesting that the functional improvements observed were independent of the gonadotropic effects of GnRH, and could instead be due to the mobilization of cognitive reserves in male Ts65Dn mice (Manfredi‐Lozano et al, 2022). In a pilot open‐label study of 7 human patients with Down syndrome, pulsatile GnRH therapy using a LutrePulse pump, a safe treatment used for four decades in patients with CHH (Hoffman & Crowley Jr., 1982), for 6 months increased cognitive performances in these patients by 20–30% and restored functional connectivity in neuronal networks known to be altered in Down syndrome (Manfredi‐Lozano et al, 2022), approaching control values using resting‐state functional magnetic resonance imaging (Figueroa‐Jimenez, Canete‐Masse, et al, 2021; Figueroa‐Jimenez, Carbo‐Carrete, et al, 2021; Huang et al, 2015).…”