338: Maternal Tdap: how do antibodies protect newborns against pertussis?

Goldfarb, Ilona T.; Jennewein, Madeleine F.; Cosgrove, Cormac; Brown, Joelle; Krykbaeva, Marina; Cooperrider, Jennifer H.; Aneja, Jasneet; Lauer, Georg M.; Kim, Arthur Y.; Alter, Galit; Riley, Laura E.

doi:10.1016/j.ajog.2016.11.596

Cited by 2 publications

(2 citation statements)

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“…It is concerning that negative media messages persist with regards to pertussis vaccination, and that the positive theme of “vaccine safety” was rarely identified from pertussis articles. The majority of these negative articles claimed that there was inadequate trial evidence to support claims of the vaccine’s safety and efficacy, despite the growing amount of high-quality evidence from observational and randomised controlled trials [22] , [23] , [24] . Unfortunately, media articles such as these are likely to have a negative impact on vaccine uptake, as misperceptions of possible harm [8] , [17] , [25] and inadequate vaccine efficacy and need [26] , [27] are commonly cited as the primary reasons for vaccine refusal.…”

Section: Discussionmentioning

confidence: 99%

Influenza and pertussis vaccination in pregnancy: Portrayal in online media articles and perceptions of pregnant women and healthcare professionals

Wilcox

Bottrell

Paterson

et al. 2018

Vaccine

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IntroductionOnline media may influence women’s decision to undergo vaccination during pregnancy. The aims of this mixed-methods study were to: (1) examine the portrayal of maternal vaccination in online media and (2) establish the perceived target of vaccine protection as viewed by pregnant women and maternity healthcare professionals (HCPs).MethodsOnline media articles on maternal vaccination (published July-December 2012 or November 2015-April 2016) were identified through the London School of Hygiene & Tropical Medicine’s Vaccine Confidence Database and thematically analysed. Questionnaires for pregnant women and HCPs were distributed within four English hospitals (July 2017-January 2018).ResultsOf 203 articles identified, 60% related to pertussis vaccination, 33% to influenza and 6% both. The majority positively portrayed vaccination in pregnancy (97%), but inaccurate, negative articles persist which criticize pertussis vaccination’s safety and efficacy. Positively-worded articles about pertussis tended to focus on infant protection and highlight examples of recent cases, whereas positively-worded articles about influenza focused on maternal protection. These themes were reflected in questionnaire responses from 314 pregnant women and 204 HCPs, who perceived pertussis vaccination as protecting the baby, and influenza vaccination as protecting the mother, or mother and baby equally. A minority of the pregnant women surveyed intended to decline influenza (22%) or pertussis (8%) vaccination.ConclusionsThe majority of online articles support pertussis and influenza vaccination during pregnancy. The portrayal of pertussis vaccination as primarily benefiting the child, using real-examples, may influence its higher uptake compared with influenza. This approach should be considered by HCPs when recommending vaccination. HCPs should be prepared to provide advice to women hesitant about vaccination, including addressing any negative media, and consider educational strategies to counteract inaccurate information. Future studies should directly assess the influence of media on vaccine decision-making and establish which media platforms are typically used by pregnant women to gather information.

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Section: Discussionmentioning

confidence: 99%

Influenza and pertussis vaccination in pregnancy: Portrayal in online media articles and perceptions of pregnant women and healthcare professionals

Wilcox

Bottrell

Paterson

et al. 2018

Vaccine

View full text Add to dashboard Cite

show abstract

“…Maternal vaccination with a pertussis-containing vaccine is now routinely recommended in several countries and has been shown to be safe and to result in high concentrations of antibody in the infant over the first 2 months of life ( 18 – 21 ). Furthermore, maternal vaccination against pertussis has been demonstrated to have an effectiveness of over 90% at preventing disease in infants up to 3 months of age ( 22 – 24 ). Little is known regarding the beneficial effects of vaccination in pregnancy on breast-feeding, in which the transfer of secretory immunoglobulin A (IgA) antibodies serve to protect infants in the first few months of life by binding and opsonizing pathogenic microorganisms ( 25 ).…”

Section: The Role Of Vaccination In Pregnancymentioning

confidence: 99%

Factors Affecting the FcRn-Mediated Transplacental Transfer of Antibodies and Implications for Vaccination in Pregnancy

2017

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At birth, neonates are particularly vulnerable to infection and transplacental transfer of immunoglobulin G (IgG) from mother to fetus provides crucial protection in the first weeks of life. Transcytosis of IgG occurs via binding with the neonatal Fc receptor (FcRn) in the placental synctiotrophoblast. As maternal vaccination becomes an increasingly important strategy for the protection of young infants, improving our understanding of transplacental transfer and the factors that may affect this will become increasingly important, especially in low-income countries where the burden of morbidity and mortality is highest. This review highlights factors of relevance to maternal vaccination that may modulate placental transfer—IgG subclass, glycosylation of antibody, total maternal IgG concentration, maternal disease, infant gestational age, and birthweight—and outlines the conflicting evidence and questions that remain regarding the complexities of these relationships. Furthermore, the intricacies of the Ab–FcRn interaction remain poorly understood and models that may help address future research questions are described.

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338: Maternal Tdap: how do antibodies protect newborns against pertussis?

Cited by 2 publications

References 0 publications

Influenza and pertussis vaccination in pregnancy: Portrayal in online media articles and perceptions of pregnant women and healthcare professionals

Influenza and pertussis vaccination in pregnancy: Portrayal in online media articles and perceptions of pregnant women and healthcare professionals

Factors Affecting the FcRn-Mediated Transplacental Transfer of Antibodies and Implications for Vaccination in Pregnancy

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