The relation between increased carotid intima‐media thickness with fibrin monomers in obese children

Abstract

Aim: This study aimed to investigate the association between carotid intima-media changes that play a part in the atherosclerotic process in childhood obesity and fibrin monomers as an important indicator of fibrin plaque.Methods: This is a cross-sectional study of obese children and non-obese healthy control subjects. Height, weight, body mass index, waist/hip ratio, systolic/diastolic blood pressures were recorded, in addition, biochemistry, haemogram, fibrin monomers and d-dimer were measured in both groups. Right and left common carotid intima-media thicknesses were measured by ultrasonography and mean carotid intima-media thickness was calculated.Results: Obese children (n = 89, 46.1% girls, median age: 12.6 ± 2.3 years) and healthy control group (n = 40, 52.5% girls, median age: 13.2 ± 2.2 years) were comparable in terms of gender, age and puberty stage. Mean carotid intima-media thickness was higher in obese children than the healthy control group (P = .002). There was no difference between the two groups in terms of fibrin monomers and d-dimer levels. In obese children, there was a weak negative correlation between mean carotid intimamedia thickness and fibrin monomers (P = .030, r = −0.233). Conclusion:In obese children, mean carotid intima-media thickness was determined higher, as an early indicator of atherosclerosis. We want to emphasise that obese children are at risk for cardiovascular disease and should be evaluated in terms of atherosclerosis. This study investigates the relation between increased carotid intimamedia thickness and fibrin monomers, in children, the first time in Literature. What's knownIt is possible to reveal the early period of the atherosclerosis process by showing carotid intimamedial thickness. Fibrin is a major component of many atherosclerotic plaques. What's newOur study investigated the relationship between mean carotid intima-media thickness in childhood obesity and fibrin monomers. But no positive correlation was found between fibrin monomers and the carotid intima-media thickness.

Assessing the Relationship between Systemic Immune-Inflammation Index and Metabolic Syndrome in Children with Obesity

“…In Romania, one in four children over the age of six was found to be either overweight or obese [6]. A growing body of studies has linked childhood abdominal obesity to heightened cardiometabolic risk and pointed out early structural changes, such as left ventricular hypertrophy and increased carotid intima-media thickness [7][8][9][10][11][12][13].…”