Corrigendum to: A coevolved EDS1-SAG101-NRG1 module mediates cell death signaling by TIR-domain immune receptors

Lapin, Dmitry; Kováčová, Viera; Dongus, Joram A; Bhandari, Deepak D.; Born, Patrick von; Bautor, Jaqueline; Guarneri, Nina; Rzemieniewski, Jakub; Stuttmann, Johannes; Beyer, Andreas; Parker, Jane E.

doi:10.1093/plcell/koab085

Cited by 1 publication

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“…Usually, EDS1 and PAD4 work together, but they can also function independently. For example, EDS1 interacts with SAG101-NRG1 module in TNL-triggered ETI to induce host cell death and transcriptional reprogramming without needing PAD4 (Lapin et al, 2019).…”

Section: Eds1: a Multitalented Defender Eds1 And Its Interacting Partners Trigger Distinct Pathwaysmentioning

confidence: 99%

“…EDS1-PAD4 interacts with ADR1 type of RNLs to regulate basal immunity by transcriptionally modifying SA signaling pathway to induce local and systemic defense under TNL/ CNL-triggered ETI (Bonardi et al, 2011;Cui et al, 2017;Lapin et al, 2019;Saile et al, 2020). Recently, Sun et al (2021) showed that EDS1-PAD4-ADR1 and EDS1-SAG101-NRG1 constitute two separate immunity signaling nodes downstream of NLR activation to boost basal immunity against pathogens.…”

Section: Eds1: a Multitalented Defender Eds1 And Its Interacting Partners Trigger Distinct Pathwaysmentioning

confidence: 99%

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Transcriptional Coactivators: Driving Force of Plant Immunity

et al. 2022

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Salicylic acid (SA) is a plant defense signal that mediates local and systemic immune responses against pathogen invasion. However, the underlying mechanism of SA-mediated defense is very complex due to the involvement of various positive and negative regulators to fine-tune its signaling in diverse pathosystems. Upon pathogen infections, elevated level of SA promotes massive transcriptional reprogramming in which Non-expresser of PR genes 1 (NPR1) acts as a central hub and transcriptional coactivator in defense responses. Recent findings show that Enhanced Disease Susceptibility 1 (EDS1) also functions as a transcriptional coactivator and stimulates the expression of PR1 in the presence of NPR1 and SA. Furthermore, EDS1 stabilizes NPR1 protein level, while NPR1 sustains EDS1 expression during pathogenic infection. The interaction of NPR1 and EDS1 coactivators initiates transcriptional reprogramming by recruiting cyclin-dependent kinase 8 in the Mediator complex to control immune responses. In this review, we highlight the recent breakthroughs that considerably advance our understanding on how transcriptional coactivators interact with their functional partners to trigger distinct pathways to facilitate immune responses, and how SA accumulation induces dynamic changes in NPR1 structure for transcriptional reprogramming. In addition, the functions of different Mediator subunits in SA-mediated plant immunity are also discussed in light of recent discoveries. Taken together, the available evidence suggests that transcriptional coactivators are essential and potent regulators of plant defense pathways and play crucial roles in coordinating plant immune responses during plant–pathogen interactions.

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Section: Eds1: a Multitalented Defender Eds1 And Its Interacting Partners Trigger Distinct Pathwaysmentioning

confidence: 99%