Real-world database analysis of the characteristics and treatment patterns of patients with endometrial cancer in Japan

Akada, Keishi; Koyama, Noriyuki; Miura, Takuma; Fukunaga, Eiji; Miura, Yuji; Aoshima, Ken

doi:10.1080/03007995.2021.1903847

Cited by 8 publications

(4 citation statements)

References 37 publications

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“…Real-world evidence is becoming increasingly valuable in enabling patient access to efficacious emerging treatment regimens, including for use in regulatory decisions and development of treatment guidelines [17,18], in addition to its utility in identifying unmet needs and treatment patterns within a disease landscape [19]. Real-world data on characteristics and treatment patterns may help also determine optimal treatment strategies in patients with advanced endometrial cancer, provide data on SoC for use in health technology assessments, and further highlight the unmet medical need for patients with recurrent disease [20].…”

Section: Introductionmentioning

confidence: 99%

Previously treated recurrent or advanced endometrial cancer in England: A real-world observational analysis

Heffernan

Nikitas

Shukla

et al. 2022

Gynecologic Oncology

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Section: Introductionmentioning

confidence: 99%

Previously treated recurrent or advanced endometrial cancer in England: A real-world observational analysis

Heffernan

Nikitas

Shukla

et al. 2022

Gynecologic Oncology

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“…Our data reflect real-world treatment patterns and outcomes in a mainly community, as opposed to an academic, setting and fill an important unmet need in the literature for data on outcomes of high-risk patients in this setting. The limited real-world data published specifically in advanced EC to date [38,39] do not provide comparable populations with which to compare our results. Nevertheless, the scale and scope of the real-world dataset analyzed, and its rich source of both structured and unstructured data, may be nationally representative of the US population, so results from our analyses may be generalizable to other patients outside the dataset.…”

Section: Crudementioning

confidence: 90%

Real-world outcomes in patients with advanced endometrial cancer: A retrospective cohort study of US electronic health records

Monk

Smith

Lima

et al. 2022

Gynecologic Oncology

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This retrospective cohort study characterized real-world outcomes of women with advanced endometrial cancer in the USA.• Most women received platinum-based combination chemotherapy as first systemic treatment for advanced/recurrent disease.• Survival outcomes were poor overall, particularly in women with advanced uterine serous carcinoma.• Black/African American women had worse outcomes than white women despite similar demographics and treatment pathways.

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“…In 2007, morbidity due to endometrial cancer exceeded that of cervical cancer, making endometrial cancer the most common gynaecologic cancer ( 3 , 4 ). Currently, most cases of endometrial cancer are identified while the disease is still in its early stages, and the mortality rate associated with endometrial cancer is the lowest among gynaecologic cancers ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

“…In particular, staging based on surgical findings has been a critical step in the clinical management of endometrial cancer since 1988, when the International Federation of Gynecology and Obstetrics (FIGO) system was introduced. According to FIGO2008—the current diagnostic system—74.4% of cases of endometrial cancer in Japan in 2020 were stage I, 5.1% were stage II, 12.0% were stage III and 8.4% were stage IV ( 5 ). In addition, the main adverse prognostic factor for endometrial cancer is lymph node metastasis (LNM), which is evaluated surgically through conventional lymph node biopsy, sentinel lymph node (SLN) biopsy and systemic lymphadenectomy.…”

Section: Introductionmentioning

confidence: 99%

Use of clinical variables for preoperative prediction of lymph node metastasis in endometrial cancer

Ueno,

Yoshida,

Nojiri

et al. 2023

Japanese Journal of Clinical Oncology

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Objective Endometrial cancer is the most common gynaecological cancer, and most patients are identified during early disease stages. Noninvasive evaluation of lymph node metastasis likely will improve the quality of clinical treatment, for example, by omitting unnecessary lymphadenectomy. Methods The study population comprised 611 patients with endometrial cancer who underwent lymphadenectomy at four types of institutions, comprising seven hospitals in total. We systematically assessed the association of 18 preoperative clinical variables with postoperative lymph node metastasis. We then constructed statistical models for preoperative lymph node metastasis prediction and assessed their performance with a previously proposed system, in which the score was determined by counting the number of high-risk variables among the four predefined ones. Results Of the preoperative 18 variables evaluated, 10 were significantly associated with postoperative lymph node metastasis. A logistic regression model achieved an area under the curve of 0.85 in predicting lymph node metastasis; this value is significantly higher than that from the previous system (area under the curve, 0.74). When we set the false-negative rate to ~1%, the new predictive model increased the rate of true negatives to 21%, compared with 6.8% from the previous one. We also provide a spreadsheet-based tool for further evaluation of its ability to predict lymph node metastasis in endometrial cancer. Conclusions Our new lymph node metastasis prediction method, which was based solely on preoperative clinical variables, performed significantly better than the previous method. Although additional evaluation is necessary for its clinical use, our noninvasive system may help improve the clinical treatment of endometrial cancer, complementing minimally invasive sentinel lymph node biopsy.

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Real-world database analysis of the characteristics and treatment patterns of patients with endometrial cancer in Japan

Cited by 8 publications

References 37 publications

Previously treated recurrent or advanced endometrial cancer in England: A real-world observational analysis

Previously treated recurrent or advanced endometrial cancer in England: A real-world observational analysis

Real-world outcomes in patients with advanced endometrial cancer: A retrospective cohort study of US electronic health records

Use of clinical variables for preoperative prediction of lymph node metastasis in endometrial cancer

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