Oral Pycnogenol® Intake Benefits the Skin in Urban Chinese Outdoor Workers: A Randomized, Placebo-Controlled, Double-Blind, and Crossover Intervention Study

Zhao, Hua; Wu, Jin-hao; Wang, Nan; Krutmann, Jean; Liu, Wei

doi:10.1159/000514323

Cited by 9 publications

(8 citation statements)

References 27 publications

(41 reference statements)

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“…Similarly, a significant improvement of TEWL was recently shown for urban outdoor workers in a randomized, placebo-controlled, double blind, cross-over intervention study after taking 2 × 50 mg Pycnogenol ® over a period of 3 months in autumn in Shanghai. 35 In that study, a significant effect of Pycnogenol ® on TEWL was only observed in the group, consuming the Pycnogenol ® in the moderate season pointing to the seasonality of that parameter.…”

Section: Resultsmentioning

confidence: 76%

An oral French maritime pine bark extract improves hair density in menopausal women: A randomized, placebo‐controlled, double blind intervention study

Cai¹,

Zeng²,

Lin³

et al. 2023

Health Science Reports

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Background and Aims Female pattern hair loss affects females of all ages with a trend to increase after menopause. This disorder may have significant psychological impact and lead to anxiety and depression. Objective In a single center, double blind, randomized, placebo‐controlled study, the effects of oral Pycnogenol® intake (3 × 50 mg/day for a total of 6 months) on hair density, scalp microcirculation, and a variety of skin physiological parameters was studied in Han Chinese menopausal women (N = 76) in Shanghai, China. Methods Measurements were taken at the beginning and after 2 and 6 months, respectively. Hair density was determined by digital photographs and further evaluated by Trichoscan software. Transepidermal water loss was measured by a humidity sensor in a closed chamber on the skin surface. Changes in microcirculation were detected as resting flux on the scalp by reflection photoplethysmography. Results Pycnogenol® intake significantly increased hair density by 30% and 23% after 2 and 6 months of treatment, respectively, as detected by Trichoscan® evaluation of digital photographs. Interestingly, photoplethysmography revealed that this beneficial effect was associated with a decrease in resting flux of the scalp skin, which might indicate an improvement of microcirculation. None of these effects were observed in the placebo taking group. In addition, a significant transient decrease of transepidermal water loss was observed in scalp skin under Pycnogenol,® but not placebo treatment. Conclusion Oral intake of Pycnogenol® might have the potential to reduce hair loss in postmenopausal women.

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Section: Resultsmentioning

confidence: 76%

An oral French maritime pine bark extract improves hair density in menopausal women: A randomized, placebo‐controlled, double blind intervention study

Cai¹,

Zeng²,

Lin³

et al. 2023

Health Science Reports

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“…Anti-inflammatory action of Pycnogenol ® , like the reduction of inflammation mediators was shown in RDP trials on joint health as well as on respiratory health ( 40 , 49 ). Pycnogenol ® ’s favorable impact on blood circulation was demonstrated in multiple ways, like the improvement of endothelial function or microcirculation in clinical RDP trials on cardiovascular health, chronic venous insufficiency, on skin and hair health, eye health and menopause ( 9 , 11 , 12 , 20 – 22 , 28 – 33 , 43 – 47 ). Improved skin elasticity, skin moisture, joint flexibility and hair health illustrate the beneficial effects of Pycnogenol ® on the extracellular matrix, observed in RDP studies ( 40 – 44 ).…”

Section: Discussionmentioning

confidence: 99%

“…A study on skin health and one recently published study on hair quality have shown Pycnogenol ® ’s effects on beauty and skin health in RDP setups ( 43 , 44 ).…”

Section: Randomized Double-blind Placebo-controlled Human Clinical St...mentioning

confidence: 99%

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Pycnogenol® French maritime pine bark extract in randomized, double-blind, placebo-controlled human clinical studies

Weichmann,

Rohdewald

2024

Front. Nutr.

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Pycnogenol® French maritime pine bark extract is a well-known and thoroughly studied patented extract from the bark of Pinus pinaster Ait. ssp. Atlantica. In 39 randomized double-blind, placebo-controlled (RDP) human clinical trials including 2,009 subjects, Pycnogenol® French maritime pine bark extract supplementation for two weeks to six months has been shown to beneficially affect cardiovascular health, chronic venous insufficiency, cognition, joint health, skin health, eye health, women’s health, respiratory health and allergies, oral health and sports performance. The mechanisms of action that can explain the respective effects on different conditions in the human body are discussed as well. As investigated in several in vitro, in vivo and in clinical studies, Pycnogenol® French maritime pine bark extract showed antioxidative effects, anti-inflammatory abilities, beneficial effects on endothelial function and reinforcing effects on the extracellular matrix. The present review aims to give a comprehensive overview of currently available “gold standard” RDP trials of Pycnogenol®’s benefits across various health domains compared to placebo. In addition, some of the processes on which the presented effects of Pycnogenol® French maritime pine bark extract are based will be elucidated and discussed. This broad overview of RDP studies on Pycnogenol® in different health domains can be used as a basis for further research on applications and mechanisms of this unique French maritime pine bark extract.

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“…French maritime pine ( Pinus pinaster ) bark extract is a plant extract containing proanthocyanidins and other antioxidant compounds. Oral Pycnogenol (the standardized extract) [ 85 ] in association with broad-spectrum sunscreen [ 86 ] has been shown to be effective in the treatment of facial melasma, and was also found to prevent skin darkening in Chinese outdoor workers [ 87 ].…”

Section: Preventing and Treating Hyperpigmentation In The Context Of ...mentioning

confidence: 99%

Commentary: Facial Aesthetic Dermatological Procedures and Photoprotection in Chinese Populations

Liu

Krutmann

Tian

et al. 2022

Dermatol Ther (Heidelb)

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The medical literature on aesthetic dermatology has primarily focused on a light-skinned patient population, yet patients of darker skin types have different needs and priorities. In Chinese individuals, key concerns include altered pigmentation, which is perceived to age the individual, and also relates to the Chinese cultural standard of beauty of fair skin; many seek aesthetic treatment for this. Non-invasive cosmetic procedures such as lasers and injections are also gaining in popularity in the Chinese market, but this population is prone to hyperpigmentation as an adverse effect of such procedures. Considered and tailored approaches, both to primary concerns of photoaging and the side effects of cosmetic treatments, are warranted.

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Oral Pycnogenol® Intake Benefits the Skin in Urban Chinese Outdoor Workers: A Randomized, Placebo-Controlled, Double-Blind, and Crossover Intervention Study

Cited by 9 publications

References 27 publications

An oral French maritime pine bark extract improves hair density in menopausal women: A randomized, placebo‐controlled, double blind intervention study

An oral French maritime pine bark extract improves hair density in menopausal women: A randomized, placebo‐controlled, double blind intervention study

Pycnogenol® French maritime pine bark extract in randomized, double-blind, placebo-controlled human clinical studies

Commentary: Facial Aesthetic Dermatological Procedures and Photoprotection in Chinese Populations

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