Gut-microbiota modulation: The impact of the gut-microbiota on osteoarthritis

Arora, Vipin; Singh, Gurjit; O-Sullivan, InSug; Ma, Kaige; Anbazhagan, Arivarasu Natarajan; Votta-Velis, E. Gina; Bruce, Benjamin; Richard, Ripper; Wijnen, André J. van; Im, Hee-Jeong

doi:10.1016/j.gene.2021.145619

Cited by 20 publications

(13 citation statements)

References 118 publications

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“…( Korotkyi et al., 2019 ) reported that probiotics upregulated the expression of type II collagen fiber alpha 1, a major gene encoding articular cartilage proteins that underlie cartilage tissue repair. Arora et al. (2021) indicated that probiotics can be available for mitigating symptoms (pain) and/or delaying pathological progression (joint degeneration) of OA.…”

Section: Gut Microbiota Modulation: a New Therapy For Oamentioning

confidence: 99%

“…(2021) indicated that probiotics can be available for mitigating symptoms (pain) and/or delaying pathological progression (joint degeneration) of OA. In the review article of Arora et al., it also was profiled that probiotics played a significant role in the key effect signaling pathways of OA via inhibition of vascular endothelial growth factor signaling, reduction of serum C-reactive protein (CRP) levels, reduction of oxidative stress and regulation of inflammatory markers in OA, such as pro-inflammatory cytokines and MMPs ( Arora et al., 2021 ). In addition, some evidences from animal studies showed that prebiotics ameliorated OA status through modifying gut microbiota.…”

Section: Gut Microbiota Modulation: a New Therapy For Oamentioning

confidence: 99%

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Association Between Gut Microbiota and Osteoarthritis: A Review of Evidence for Potential Mechanisms and Therapeutics

Wei

2022

Front. Cell. Infect. Microbiol.

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Osteoarthritis (OA) is a multifactorial joint disease characterized by degeneration of articular cartilage, which leads to joints pain, disability and reduced quality of life in patients with OA. Interpreting the potential mechanisms underlying OA pathogenesis is crucial to the development of new disease modifying treatments. Although multiple factors contribute to the initiation and progression of OA, gut microbiota has gradually been regarded as an important pathogenic factor in the development of OA. Gut microbiota can be regarded as a multifunctional “organ”, closely related to a series of immune, metabolic and neurological functions. This review summarized research evidences supporting the correlation between gut microbiota and OA, and interpreted the potential mechanisms underlying the correlation from four aspects: immune system, metabolism, gut-brain axis and gut microbiota modulation. Future research should focus on whether there are specific gut microbiota composition or even specific pathogens and the corresponding signaling pathways that contribute to the initiation and progression of OA, and validate the potential of targeting gut microbiota for the treatment of patients with OA.

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Section: Gut Microbiota Modulation: a New Therapy For Oamentioning

confidence: 99%

Section: Gut Microbiota Modulation: a New Therapy For Oamentioning

confidence: 99%

Association Between Gut Microbiota and Osteoarthritis: A Review of Evidence for Potential Mechanisms and Therapeutics

Wei

2022

Front. Cell. Infect. Microbiol.

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“…The topic of the capacity of the gut microbiome to regulate pain has been the subject of many recent reviews. Table 1 [8,9,11,[32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51] illustrates and summarizes 23 of these review articles that detail a variety of aspects surrounding pain initiation, detection, biochemistry, and management. As captured among these reviews, there has been an explosion of research on this topic over the past five years.…”

Section: Painmentioning

confidence: 99%

Microbiome First Approaches in Pain Prevention and Management

Dietert

2021

AJBSR

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The Microbiome First Initiative aims to facilitate sustainable healthcare by focusing first and foremost on the human holobiont majority, the microbiome. Understanding how the human microbiome affects not only risk of disease but also human perceptions can help individuals thrive and pave the way for a healthy life course. Following a recent review of Microbiome First Medicine the context of health and safety, this present opinion article considers the role of the human microbiome, particularly the gut microbiome, on pain, sensory perceptions, and the prevention and multimodal management of pain. Microbial dysbiosis can be causative of some forms of immune-inflammatory and neurologic pain and the altered human microbiome can lock in the pain while at the same time interfering with analgesic/opioid therapies. Dysbiotic microbiota can make drug treatments less effective and with opioids, the microbes can significantly increase:1. Opioid tolerance 2. The risk of addiction 3. The likelihood of withdrawal failure.For these reasons, it is critical to move beyond simply thinking about the microbiome in dealing with pain to considering the microbiome as central in multimodal pain prevention and management strategies. The microbiome is key in any attempts to change physiology, metabolism, systems biology function, and receptor-based perceptions within the human body.

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“…This indicates similar trafficking of gut microbiota (dead or alive bacteria) between the gut and epiphysial bone marrow ( 20 , 21 ). The curative effects of probiotics ( L. casei, L. acidophilus , and Bifdobacterium longum ) on metabolic bone diseases have also been demonstrated ( 22 , 23 ).…”

Section: Introductionmentioning

confidence: 99%

Comparative Analysis of the Bioactive Compounds in Chicken Cartilage: Protective Effects of Chondroitin Sulfate and Type II Collagen Peptides Against Osteoarthritis Involve Gut Microbiota

Zhang

Shen

et al. 2022

Front. Nutr.

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This study was designed to explore osteoarthritis (OA) treatment from bioactive compounds of chicken cartilage food supplements. The OA rat model induced by sodium iodoacetate was used to evaluate the treatment effect in vivo. In this study, we used animal experiments to show that oral chondroitin sulfate (CS), cartilage powder, and type II collagen peptides could increase the athletic ability of rats and reduce inflammatory cytokine levels in serum or synovial fluid, including prostaglandin E2, tumor necrosis factor-α, interleukin (IL) 1β, IL-6, and IL-17. CS displayed the best treatment effect against OA. The morphological structure of articular cartilage indicated that CS could significantly improve cartilage tissue morphology and reduce OA score. Oral CS slowed down the development of OA by modulating gut microbiota. These results provided a useful scientific basis for the high-value utilization of chicken cartilage.

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Gut-microbiota modulation: The impact of the gut-microbiota on osteoarthritis

Cited by 20 publications

References 118 publications

Association Between Gut Microbiota and Osteoarthritis: A Review of Evidence for Potential Mechanisms and Therapeutics

Association Between Gut Microbiota and Osteoarthritis: A Review of Evidence for Potential Mechanisms and Therapeutics

Microbiome First Approaches in Pain Prevention and Management

Comparative Analysis of the Bioactive Compounds in Chicken Cartilage: Protective Effects of Chondroitin Sulfate and Type II Collagen Peptides Against Osteoarthritis Involve Gut Microbiota

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