CircRNA-Mediated Regulation of Angiogenesis: A New Chapter in Cancer Biology

Jiang, Shaotao; Fu, Rongdang; Shi, Jinhua; Wu, Huihui; Mai, Jialuo; Hua, Xuefeng; Chen, Huan; Liu, Jie; Lu, Min-qiang; Li, Ning

doi:10.3389/fonc.2021.553706

Cited by 16 publications

(10 citation statements)

References 116 publications

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“… 221 CircRNAs have low expression in cells and they were first believed to be a result of RNA splicing. 222 CircRNAs are stable in multiple tissues and body fluids. 217 , 223 They lack protein encoding capacity and they have a closed loop structure.…”

Section: Beta-catenin and Hepatocellular Carcinomamentioning

confidence: 99%

Wnt/β-Catenin Signaling as a Driver of Hepatocellular Carcinoma Progression: An Emphasis on Molecular Pathways

Paskeh

Mirzaei

Ashrafizadeh

et al. 2021

JHC

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Section: Beta-catenin and Hepatocellular Carcinomamentioning

confidence: 99%

Wnt/β-Catenin Signaling as a Driver of Hepatocellular Carcinoma Progression: An Emphasis on Molecular Pathways

Paskeh

Mirzaei

Ashrafizadeh

et al. 2021

JHC

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“…2B ). As shown in previous studies, the lack of a 5′ cap and a 3′ polyadenylated tail provided circRNAs with more stability than linear mRNA [ 11 ]. Next, we treated PANC-1 and MIA-PaCa2 cells with RNase R, and evaluated degradation via RT-qPCR.…”

Section: Resultsmentioning

confidence: 81%

“…Circular RNAs (circRNAs), a class of novel noncoding RNAs, were discovered in 1976. CircRNAs derive from non-canonical splices of pre-mRNAs, and form a covalently closed loop structure lacking 5′ caps and 3′ tails [ 11 ]. CircRNAs present higher stability and resistance to exonuclease compared to the parental linear RNAs [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Autophagy-associated circRNA circATG7 facilitates autophagy and promotes pancreatic cancer progression

Cai

Zeng

et al. 2022

Cell Death Dis

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Dysregulation of autophagy and circular RNAs (circRNAs) are involved in the pancreatic cancer (PC) progression. However, the regulatory network between circRNAs, autophagy, and PC progression remains unknown. Herein, we demonstrated that autophagy-associated circRNA circ-autophagy related 7 (circATG7) was elevated in PC tissues compared to adjacent tissues, and in PC cells treated with EBSS and hypoxia. circATG7 expression was positively associated with tumor diameter and lymph node invasion in patients with PC. circATG7 overexpression promoted PC cell proliferation, mobility, and autophagy in vitro, while circATG7 knockdown induced the opposite effects. ATG7 inhibition attenuated the effects of circATG7 on the biological functions of PC cells. CircATG7 is located in the cell cytoplasm and nucleus. Cytoplasmic circATG7 sponged miR-766-5p and decreased its expression, and increased the expression of ATG7, a target gene of miR-766-5p. Nuclear circATG7 acted as a scaffold to increase the interaction between the human antigen R protein and ATG7 mRNA and enhanced ATG mRNA stability. Furthermore, we demonstrated that circATG7 regulates PC cell proliferation and metastasis in vivo via ATG7-dependent autophagy. In conclusion, our results demonstrated that circATG7 accelerates PC progression via miR-766-5p/ATG7 and that HUR/ATG7 depends on autophagic flux. Thus, circATG7 may be a potential therapeutic target for PC.

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“…Angiogenesis: Angiogenesis-dependent tumor growth is an important characteristic of cancers[ 96 ]. Vascular endothelial GF (VEGF) and hypoxia-inducible factor-1α (HIF-1α) are critical in promoting tumor angiogenesis[ 104 ]. Under hypoxic conditions, HIF-1α and HIF-1β subunits form heterodimers that activate the transcription of many target genes to adapt to the hypoxic environment of human cancer cells[ 105 ].…”

Section: Molecular Mechanisms Of Foxos In Gcmentioning

confidence: 99%

Diverse roles of FOXO family members in gastric cancer

Chen

et al. 2021

WJGO

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Gastric cancer (GC) is the fifth most diagnosed cancer and the third leading cause of cancer-related death worldwide. Although progress has been made in diagnosis, surgical resection, systemic chemotherapy, and immunotherapy, patients with GC still have a poor prognosis. The overall 5-year survival rate in patients with advanced GC is less than 5%. The FOXO subfamily, of the forkhead box family of transcription factors, consists of four members, FOXO1, FOXO3, FOXO4, and FOXO6. This subfamily plays an important role in many cellular processes, such as cell cycle, cell growth, apoptosis, autophagy, stress resistance, protection from aggregate toxicity, DNA repair, tumor suppression, and metabolism, in both normal tissue and malignant tumors. Various studies support a role for FOXOs as tumor suppressors based on their ability to inhibit angiogenesis and metastasis, and promote apoptosis, yet several other studies have shown that FOXOs might also promote tumor progression in certain circumstances. To elucidate the diverse roles of FOXOs in GC, this article systematically reviews the cellular functions of FOXOs in GC to determine potential therapeutic targets and treatment strategies for patients with GC.

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CircRNA-Mediated Regulation of Angiogenesis: A New Chapter in Cancer Biology

Cited by 16 publications

References 116 publications

Wnt/β-Catenin Signaling as a Driver of Hepatocellular Carcinoma Progression: An Emphasis on Molecular Pathways

Wnt/β-Catenin Signaling as a Driver of Hepatocellular Carcinoma Progression: An Emphasis on Molecular Pathways

Autophagy-associated circRNA circATG7 facilitates autophagy and promotes pancreatic cancer progression

Diverse roles of FOXO family members in gastric cancer

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