Breast Metastasis of Gastric Signet Ring Cell Carcinoma: A Case Report and Literature Review

Buerba-Vieregge, Hector Hugo; Fernández-Ferreira, Ricardo; Soberanis-Piña, Pamela Denisse; Peña-López, Ildefonso Roberto De la; Navarro-García, Lilian; Macari-Jorge, Andrés

doi:10.1159/000510938

Cited by 7 publications

(4 citation statements)

References 29 publications

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“…Gastric tumors rarely metastasize to the breast, however the main sites of metastasis are the peritoneum, liver, lung, lymph nodes and bone [ 5 , 7 , 12 ], while the major sites of metastasis in the gastric signet ring cell carcinoma subtype, which is the case we are reporting here, are the lymph nodes and peritoneum, the breast is an uncommon site of metastasis and is rarely reported, except in a few clinical cases [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

Unusual Metastasis of Gastric Signet Ring Cell Carcinoma to the Breast: A Case Report of a Young Moroccan Patient

Bendimya,

Kairouani,

El Magroud

et al. 2024

Cureus

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Although gastric cancer is known to be an aggressive tumor that can spread throughout the body, breast metastases are uncommon. This entity is rarely reported in the literature, with an estimated incidence of 0.5 to 1.3%. We report a case of a rare association between a gastric subtype of signet ring cell carcinoma and metastasis to the breast. This uncommon situation is only documented through case reports. Most breast metastases have been detected after diagnosis of primary gastric cancer, during the first year. Several risk factors have been suggested to explain the aggressive behavior of these tumors, which correlates with very poor prognosis and short survival. We report the case of a 22-year-old female patient presenting with widespread metastatic gastric signet ring cell carcinoma with an unusual secondary site in the breast. The diagnosis was confirmed by immunohistochemistry (IHC) and radiology, and the patient was treated with palliative chemotherapy in accordance with the decision of the multidisciplinary tumor board.

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Section: Discussionmentioning

confidence: 99%

Unusual Metastasis of Gastric Signet Ring Cell Carcinoma to the Breast: A Case Report of a Young Moroccan Patient

Bendimya,

Kairouani,

El Magroud

et al. 2024

Cureus

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“…Estrogen has been proposed to promote extramammary tumorigenesis[ 11 ]. The ER-β is expressed in some gastric adenocarcinomas, particularly indolent cell carcinoma, and may mediate estrogen-induced proliferation of tumor cells in extramammary regions[ 15 , 16 ]. Additionally, young gastric cancers associated with hormonal factors appear more aggressive, and gastric cancer growth may be influenced by the hormonal environment[ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Gastric cancer metastatic to the breast: A case report

Liu,

Dhamija,

Jiang

et al. 2024

World J Gastrointest Oncol

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BACKGROUND Metastatic breast cancer originating in the gastrointestinal tract is a rare occurrence. The limited number of cases has resulted in incomplete understanding of the disease, making it challenging to differentiate from primary breast cancer. While clinical history and immunohistochemical studies can aid in distinguishing between the two, the management principles and pathogenesis of gastrointestinal metastatic breast cancer remain controversial. The scarcity of data has hampered comprehensive knowledge. Our objective is to shed light on this rare disease through our case study. CASE SUMMARY Here, we report a case of breast metastasis from gastric cancer in a 43-year-old woman. This patient was admitted to our hospital with complaints of discomfort in the upper and middle abdomen persisting for two months, as well as black stools for over ten days. She underwent radical distal gastrectomy for gastric cancer, followed by postoperative chemotherapy. Three years later, the patient developed bilateral breast nodules. Imaging studies indicated a high probability of malignancy. She subsequently underwent a right modified radical mastectomy and excision of a left breast mass. Postoperative pathology revealed the right breast tumor was consistent with primary gastric cancer. CONCLUSION We present a case of breast metastasis from gastric cancer to contribute to the limited foundation of research into this rare disease.

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“…10 Less than 60 cases reported in the literature of gastrointestinal cancer metastasizing to the breast. 11 Skeletal muscle metastasis from a gastric origin is even a rarer entity with a poor prognosis; and as of recent literature there is no established incidence rate for it. 12,13 Our objective is to highlight rare presentations of stomach and esophageal metastasizing to unusual locations causing a diagnostic challenge on presentation.…”

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confidence: 99%

Rare Metastasis of Esophago-Gastric Cancers: Case series with review of literature

Khalaf¹,

El-Matbouly²,

Suliman³

et al. 2022

wjoncgy

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Purpose: in this case series we aim to highlight rare metastasis of gastric and esophageal cancers metastasizing to unusual locations causing a diagnostic challenge on presentation. We also review pertinent literature of rare locations of metastasis of gastro-esophageal cancer (GEC). Materials and methods: this is a retrospective analysis of four patients managed at our institution with one year follow up between 2020-2021. We include baseline patient characteristics, presenting symptoms, diagnostic work up and management of each individual case. Results: Out of the 4 cases with GEC; two had gastric adenocarcinoma, one esophageal adenocarcinoma and one gastroesophageal junction adenocarcinoma which metastasized to various locations throughout the body. Among the rarest locations of metastasis of gastric cancer is skeletal muscles. The locations of metastases were: ovaries and peritoneum from gastric adenocarcinoma, brain and liver from gastric adenocarcinoma, skeletal muscles from esophageal adenocarcinoma, and skeletal muscles and breast from GEC adenocarcinoma. The main diagnostic tool to identify these rare sites metastasis was Positron emission tomography scan (PET/CT). Conclusion: Studies have shown that not all gastroesophageal malignancies present with these alarm symptoms and up to 40% of patient can present without alarming symptoms. In our study; we shed the light on the possible rare metastatic sites that could have been missed with the regular presentation. Some of the rarest location of metastasis is to the skeletal muscles, which was present in two of our patients with an origin of gastric and esophageal cancer, which was identified with PET/CT. This study clarifies the importance of including whole body PET/CT scan in the staging process for patients with esophageal and gastric cancers to identify such rare sites metastasis that will alter the stage and clinical management of GEC patients.

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Breast Metastasis of Gastric Signet Ring Cell Carcinoma: A Case Report and Literature Review

Cited by 7 publications

References 29 publications

Unusual Metastasis of Gastric Signet Ring Cell Carcinoma to the Breast: A Case Report of a Young Moroccan Patient

Unusual Metastasis of Gastric Signet Ring Cell Carcinoma to the Breast: A Case Report of a Young Moroccan Patient

Gastric cancer metastatic to the breast: A case report

Rare Metastasis of Esophago-Gastric Cancers: Case series with review of literature

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