Prevalence of pulmonary mycoses in smear-negative patients with suspected tuberculosis in the Brazilian Amazon

Matsuda, Joycenea da Silva; Wanke, Bodo; Balieiro, Antônio Alcirley da Silva; Santos, Carla Silvana da Silva; Cavalcante, Regia Cristina dos Santos; Muniz, Mauro de Medeiros; Torres, Daiana Rodrigues; Pinheiro, Silviane Bezerra; Frickmann, Hagen; Souza, João Vicente Braga de; Martínez-Espinosa, Flor Ernestina

doi:10.1016/j.riam.2020.12.004

Cited by 6 publications

(6 citation statements)

References 22 publications

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“…Some patients were Aspergillus antibody negative and/or asymptomatic, but had evidence of an aspergilloma — these cases were excluded in our estimates. In Manaus, a cross-sectional study of 213 smear-negative ‘PTB’ patients found 15 with a pulmonary mycosis based on culture, serology, and CT scanning, of whom 10 (4.7%) had CPA ( Matsuda et al., 2021 ). In Uzbekistan, 12 (20%) of 60 smear-negative TB patients had CPA ( Toychiev et al., 2022 ).…”

Section: Methodsmentioning

confidence: 99%

New estimation of the prevalence of chronic pulmonary aspergillosis (CPA) related to pulmonary TB – a revised burden for India

Denning

Cole²,

Goel³

2023

IJID Regions

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Section: Methodsmentioning

confidence: 99%

New estimation of the prevalence of chronic pulmonary aspergillosis (CPA) related to pulmonary TB – a revised burden for India

Denning

Cole²,

Goel³

2023

IJID Regions

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“…A cross sectional study from Brazil identified 15 (7%) cases of pulmonary mycoses in 213 patients managed as smear negative TB. Of the fifteen, ten were aspergillosis, three were paracoccidioidomycosis and one case each of histoplasmosis and cryptococcosis [ 74 ]. Another study from Nigeria, reported a CPA prevalence of 8.7% in 208 smear negative TB patients [ 75 ].…”

Section: Resultsmentioning

confidence: 99%

Pulmonary and Extrapulmonary Manifestations of Fungal Infections Misdiagnosed as Tuberculosis: The Need for Prompt Diagnosis and Management

Ekeng

Davies

Osaigbovo

et al. 2022

JoF

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Fungal infections commonly present with myriad symptoms that mimic other clinical entities, notable amongst which is tuberculosis. Besides histoplasmosis and chronic pulmonary aspergillosis, which can mimic TB, this review has identified several other fungal infections which also do. A total of 80 individual cases misdiagnosed as TB are highlighted: aspergillosis (n = 18, 22.5%), histoplasmosis (n = 16, 20%), blastomycosis (n = 14, 17.5%), cryptococcosis (n = 11, 13.8%), talaromycosis (n = 7, 8.8%), coccidioidomycosis (n = 5, 6.3%), mucormycosis (n = 4, 5%), sporotrichosis (n = 3, 3.8%), phaeohyphomycosis (n = 1, 1.3%) and chromoblastomycosis (n = 1, 1.3%). Case series from India and Pakistan reported over 100 cases of chronic and allergic bronchopulmonary aspergillosis had received anti-TB therapy before the correct diagnosis was made. Forty-five cases (56.3%) had favorable outcomes, and 25 (33.8%) died, outcome was unclear in the remainder. Seventeen (21.3%) cases were infected with human immunodeficiency virus (HIV). Diagnostic modalities were histopathology (n = 46, 57.5%), culture (n = 42, 52.5%), serology (n = 18, 22.5%), cytology (n = 2, 2.5%), gene sequencing (n = 5, 6.3%) and microscopy (n = 10, 12.5%) including Gram stain, India ink preparation, bone marrow smear and KOH mount. We conclude that the above fungal infections should always be considered or ruled out whenever a patient presents with symptoms suggestive of tuberculosis which is unconfirmed thereby reducing prolonged hospital stay and mortalities associated with a delayed or incorrect diagnosis of fungal infections.

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“…In Brazil, a study was performed to estimate the frequency of pulmonary mycoses in 213 smear-negative tuberculosis patients, and in 7% of the cases (15/213), pulmonary mycoses were diagnosed, comprising ten aspergillosis cases, three cases of paracoccidioidomycosis, one case of histoplasmosis, and one of cryptococcosis [12].…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Histoplasmosis in a Referral Hospital in Mexico City

Solís

Santibáñez

Olán

et al. 2022

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Pulmonary histoplasmosis is caused by inhaling Histoplasma capsulatum. Less than 1% develops the disease. Risk factors in immunocompetent individuals are environmental exposures in endemic areas. The objective of this study is to determine the frequency, clinical, and microbiological characteristics in immunocompetent patients. A retrospective case series study of patients diagnosed with pulmonary histoplasmosis was performed in a respiratory care unit in Mexico City from 2000 to 2020. Each patient had bronchial lavage, and three patients underwent thoracoscopy for the lung tissue sample taken for the culture in Sabouraud Dextrose Agar. Twelve patients were identified, 8 males and 4 females; the predominant symptoms were fever (83%), dyspnea (75%), chest pain (66%), hemoptysis (41%), and weight loss (33%). The computed tomography of the chest showed the following findings: patchy consolidation 12 (100%), hilar adenopathy 6 (50%), pleural effusion 6 (50%), caverns 3 (25%), and solitary pulmonary nodule in one patient (8%). Histoplasma capsulatum was found in the culture of all twelve patients. The signs and symptoms of the disease are mediated by the immune status of the host. The clinical picture is often confused with systemic diseases. It is important to have a high degree of clinical suspicion to make a timely diagnosis.

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Prevalence of pulmonary mycoses in smear-negative patients with suspected tuberculosis in the Brazilian Amazon

Cited by 6 publications

References 22 publications

New estimation of the prevalence of chronic pulmonary aspergillosis (CPA) related to pulmonary TB – a revised burden for India

New estimation of the prevalence of chronic pulmonary aspergillosis (CPA) related to pulmonary TB – a revised burden for India

Pulmonary and Extrapulmonary Manifestations of Fungal Infections Misdiagnosed as Tuberculosis: The Need for Prompt Diagnosis and Management

Pulmonary Histoplasmosis in a Referral Hospital in Mexico City

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