Associations between blood and urinary manganese with metabolic syndrome and its components: Cross-sectional analysis of National Health and Nutrition Examination Survey 2011–2016

Lo, Kenneth; Yang, Jing; Chen, Chao Lei; Lin, Li; Huang, Yu; Feng, Ying; Yang, Aiqin

doi:10.1016/j.scitotenv.2021.146527

Cited by 25 publications

(24 citation statements)

References 48 publications

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“…= 0.32, 0.97) and men (OR = 0.40, 95% C.I. = 0.16, 0.99) [24]. From the restricted cubic spline analysis, the U-shaped dose-response relationship between urinary Mn and MetS was observed among all participants [24].…”

Section: Urinary Mn and Metsmentioning

confidence: 93%

“…From the restricted cubic spline analysis, the U-shaped dose-response relationship between urinary Mn and MetS was observed among all participants [24]. As demonstrated by posterior inclusion probabilities (PIP), urinary Mn played a less important role in development of MetS (PIP = 0.49 for Mn versus 0.54 to 0.91 for other metals) [24]. For two case-control studies (conducted in Iran and China, respectively) that were not included in the meta-analysis, per unit increment of urinary Mn did not associate with MetS [22,27].…”

Section: Urinary Mn and Metsmentioning

confidence: 96%

“…= 0.16, 0.99) [24]. From the restricted cubic spline analysis, the U-shaped dose-response relationship between urinary Mn and MetS was observed among all participants [24]. As demonstrated by posterior inclusion probabilities (PIP), urinary Mn played a less important role in development of MetS (PIP = 0.49 for Mn versus 0.54 to 0.91 for other metals) [24].…”

Section: Urinary Mn and Metsmentioning

confidence: 97%

“…Four included studies examined the association between urinary Mn and the presence of MetS [22,24,25,27], and two of them provided adequate data for meta-analysis (Figure 2) [24,25], but the overall association between the highest level of Mn from urine and MetS was not significant (OR: 0.84, 95% C.I. = 0.59, 1.19, I 2 = 0%), and the heterogeneity across studies was not substantial (I 2 < 50%).…”

Section: Urinary Mn and Metsmentioning

confidence: 99%

“…Four of the included studies examined the association between Mn from whole blood and the presence of MetS [20,24,26,30]. For the three studies that analyzed data from U.S. NHANES, different approaches were adapted in each included study.…”

Section: Whole Blood Mn and Metsmentioning

confidence: 99%

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Manganese Exposure and Metabolic Syndrome: A Systematic Review and Meta-Analysis

Wong

Chan

2022

Nutrients

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Manganese (Mn) is an essential element acting as a co-factor of superoxide dismutase, and it is potentially beneficial for cardiometabolic health by reducing oxidative stress. Although some studies have examined the relationship between Mn and metabolic syndrome (MetS), no systematic review and meta-analysis has been presented to summarize the evidence. Therefore, the present review examined the association between dietary and environmental Mn exposure, and MetS risk. A total of nine cross-sectional studies and three case-control studies were included, which assessed Mn from diet, serum, urine, and whole blood. The association of the highest Mn level from diet (three studies, odds ratio (OR): 0.83, 95% confidence interval (C.I.) = 0.57, 1.21), serum (two studies, OR: 0.87, 95% C.I. = 0.66, 1.14), urine (two studies, OR: 0.84, 95% C.I. = 0.59, 1.19), and whole blood (two studies, OR: 0.92, 95% C.I. = 0.53, 1.60) were insignificant, but some included studies have suggested a non-linear relationship of urinary and blood Mn with MetS, and higher dietary Mn may associate with a lower MetS risk in some of the included studies. While more evidence from prospective cohorts is needed, future studies should use novel statistical approaches to evaluate relative contribution of Mn on MetS risk along with other inter-related exposures.

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Section: Urinary Mn and Metsmentioning

confidence: 93%