Frequency of antigen Dia on the blood donor population of the Hemocenter coordinator of the Hemopa Foundation

Caldas, Adna dos Santos; Santos, Bruno Costa dos; Palmeira, Maurício Koury; Carvalho, Fabiana Regina Ribeiro; Amaral, Carlos Eduardo de Melo

doi:10.1016/j.htct.2020.12.007

Cited by 2 publications

(2 citation statements)

References 13 publications

(21 reference statements)

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“…In a population with diverse ethnicities like Brazil, blood group antigens vary significantly in their frequency. Genotyping studies in this population have shown that blood group polymorphisms differ significantly from other populations (CALDAS et al, 2022;CASTILHO, 2016a), and studies within the country have also shown a heterogeneous distribution of blood group alleles and variants among people from different regions (ARNONI et al, 2015).…”

Section: Discussionmentioning

confidence: 74%

Importance of phenotyping in blood donors for the identification of rare phenotypes

Cardoso,

Vizzoni

2023

DS-CS

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Introduction: Erythrocyte alloimmunization may arise from blood group incompatibility between ethnically diverse donors and recipients. Providing blood to patients with rare or complex red cell antigen profiles poses a significant challenge. These individuals may have red blood cells that either lack high incidence antigens or possess a combination of several uncommon antigens. As a result, finding compatible blood donors becomes difficult. Methods: The objective was to identify extended phenotyping strategies for the various blood group systems to aid transfusion in patients with a phenotype considered rare. This is a systematic review, in which parameters were followed as a basis for the PRISMA recommendations with a focus on the search for the literature published in the last 10 years on erythrocyte phenotyping in blood donors, aiming to identify rare phenotypes for transfusion support. Results: We found 20 articles describing rare antigens and antibodies, reporting difficulties in finding compatible blood and the need for a registry of these blood donors. In summary, the provision of blood to patients with red cells lacking high incidence antigens or complex antigen profiles is indeed a challenging task. It necessitates specialized testing, access to rare blood donors, and alternative strategies to ensure the best possible match for transfusion.

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Section: Discussionmentioning

confidence: 74%

Importance of phenotyping in blood donors for the identification of rare phenotypes

Cardoso,

Vizzoni

2023

DS-CS

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“…Anti-serum for the Di a and Di b antigens is extremely expensive and has a short shelf life and low volume, which make them inefficient for use in routine immunohematology. 28 Currently, the Brazilian legislation does not include research on Diego antigens in the phenotyping of erythrocytes, so these antigens are only researched in specific cases. 29 In hemotherapy services, knowledge on the prevalence of blood group antigens is important to meet the transfusion needs of the population served; therefore, these services must be prepared for opportune cases or for low-frequency occurrences.…”

Section: Discussionmentioning

confidence: 99%

Frequencies of genetic variants of the Rh, Kell, Duffy, Kidd, MNS and Diego systems of northwest Rio Grande do Sul, Brazil

Soares

Aquino²,

Petrolli

et al. 2023

Hematology, Transfusion and Cell Therapy

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Frequency of antigen Dia on the blood donor population of the Hemocenter coordinator of the Hemopa Foundation

Cited by 2 publications

References 13 publications

Importance of phenotyping in blood donors for the identification of rare phenotypes

Importance of phenotyping in blood donors for the identification of rare phenotypes

Frequencies of genetic variants of the Rh, Kell, Duffy, Kidd, MNS and Diego systems of northwest Rio Grande do Sul, Brazil

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