“…Secreted ADAMTS13 protein consists of a metalloprotease (M) domain, a disintegrin (D) domain, the first thrombospondin type 1 (TSP1‐1) repeat, the Cys‐rich (C) and spacer (S) domains, followed by 7 more TSP1 repeats and two CUB domains, associated with complement components C1r/C1s, sea Urchin epidermal growth factor, Bone morphogenetic protein (Figure 1A). While the tertiary structure of a full‐length ADAMTS13 protein has yet to be determined, the truncated versions of recombinant ADAMTS13 protein (e.g., MDTCS or its variants) have recently been described using a variety of techniques, including X‐ray crystallography, small angle X‐ray scattering, and mass spectrometry plus hydrogen/deuterium exchange, and cross‐linking mass spectrometry 27,28,42,43 . The MDTCS fragment contains all the necessary and sufficient domains of ADAMTS13 protein for substrate specificity and efficient cleavage 28,43,44,45 .…”