Safety of surgical denervation of the common hepatic artery in insulin‐resistant dogs

Kraft, Guillaume; Scott, Melanie; Allen, Eric J.; Edgerton, Dale S.; Farmer, Ben; Azamian, Bobak R.; Cherrington, Alan D.

doi:10.14814/phy2.14805

Cited by 2 publications

(1 citation statement)

References 30 publications

(46 reference statements)

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“…The vast majority of HADN is currently performed by surgery, mainly by dissection of nerve fibers from the celiac ganglion plexus 1–2 cm away from the beginning of the common hepatic artery to a few centimeters after the bifurcation of the common hepatic artery ( 136 ). Results of previous animal trials have confirmed the function of surgical HADN for improving metabolic diseases such as diabetes ( 130 , 137 , 138 ), dyslipidemia and hepatocellular steatosis ( 139 – 141 ). However, surgical HADN is hardly applicable to clinical treatment because it requires general anesthesia and laparotomy, which is more invasive.…”

Section: Hepatic Artery Denervationmentioning

confidence: 65%

Device-Based Sympathetic Nerve Regulation for Cardiovascular Diseases

Xiong

et al. 2021

Front. Cardiovasc. Med.

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Sympathetic overactivation plays an important role in promoting a variety of pathophysiological processes in cardiovascular diseases (CVDs), including ventricular remodeling, vascular endothelial injury and atherosclerotic plaque progression. Device-based sympathetic nerve (SN) regulation offers a new therapeutic option for some CVDs. Renal denervation (RDN) is the most well-documented method of device-based SN regulation in clinical studies, and several large-scale randomized controlled trials have confirmed its value in patients with resistant hypertension, and some studies have also found RDN to be effective in the control of heart failure and arrhythmias. Pulmonary artery denervation (PADN) has been clinically shown to be effective in controlling pulmonary hypertension. Hepatic artery denervation (HADN) and splenic artery denervation (SADN) are relatively novel approaches that hold promise for a role in cardiovascular metabolic and inflammatory-immune related diseases, and their first-in-man studies are ongoing. In addition, baroreflex activation, spinal cord stimulation and other device-based therapies also show favorable outcomes. This review summarizes the pathophysiological rationale and the latest clinical evidence for device-based therapies for some CVDs.

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Section: Hepatic Artery Denervationmentioning

confidence: 65%

Device-Based Sympathetic Nerve Regulation for Cardiovascular Diseases

Xiong

et al. 2021

Front. Cardiovasc. Med.

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Decreasing the blood flow of non-compressible intra-abdominal organs with non-invasive transcutaneous electrical stimulation

Çakmak¹,

Khwaounjoo

Pangilinan

et al. 2022

Preprint

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Non-invasive neuromodulation of non-compressible internal organs has significant potential for internal organ bleeding and blood-shift in aero/space medicine. The present study aims to investigate the potential influences of the non-invasive transcutaneous electrical nerve stimulation (TENS) on multiple non-compressible internal organs’ blood flow. Porcine animal model (n = 8) was randomized for a total of 48 neuromodulation sessions with two different TENS stimulation frequencies (80Hz, 10Hz) and a placebo stimulation. A combination of two different electrode configurations (Abdominal or Abdominal and Hind Limb) were also performed. Intraarterial blood flow measurements were taken during pre and post-stimulation periods at the left renal artery, common hepatic artery, and left coronary artery. Intracranial, and extracranial arterial blood flows were also assessed with digital subtraction angiography. TENS with abdominal-only electrode configurations at 10hz demonstrated significant reductions in average peak blood flow velocity (APV) of the common hepatic artery (p = 0.0233) and renal arteries (p = 0.0493). Arterial pressures (p = 0.0221) were also significantly lower when renal APV was reduced. The outcome of the present study emphasises the potential use of TENS in decreasing the blood flow of non-compressible internal organs when the correct combination of electrodes configuration and frequency is used.

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Safety of surgical denervation of the common hepatic artery in insulin‐resistant dogs

Cited by 2 publications

References 30 publications

Device-Based Sympathetic Nerve Regulation for Cardiovascular Diseases

Device-Based Sympathetic Nerve Regulation for Cardiovascular Diseases

Decreasing the blood flow of non-compressible intra-abdominal organs with non-invasive transcutaneous electrical stimulation

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