A Comprehensive Workflow for the Analysis of Bio-Macromolecular Supplements: Case Study of 20 Whey Protein Products

Avula, Bharathi; Parveen, Iffat; Zhao, Jianping; Wang, Mei; Techen, Natascha; Wang, Yanhong; Riaz, Muhammad; Bae, Ji‐Yeong; Shami, Anter; Chittiboyina, Amar G.; Khan, Ikhlas A.; Sharp, Joshua S.

doi:10.1080/19390211.2021.1897724

Cited by 2 publications

(2 citation statements)

References 35 publications

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“…Macroparticles are particles larger than 1000 microns in size and are easily visible [50,51]. They are applied especially in the field of dietary supplements [52] or drugs [53][54][55][56]. The size of microparticles ranges from 100 nanometres to 1000 µm [57][58][59], and particles with a diameter below 100 nanometres are classified as nanoparticles [60].…”

Section: Cross-linking Of Alginatesmentioning

confidence: 99%

Preparation and Characteristics of Alginate Microparticles for Food, Pharmaceutical and Cosmetic Applications

2022

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Alginates are the most widely used natural polymers in the pharmaceutical, food and cosmetic industries. Usually, they are applied as a thickening, gel-forming and stabilizing agent. Moreover, the alginate-based formulations such as matrices, membranes, nanospheres or microcapsules are often used as delivery systems. Alginate microparticles (AMP) are biocompatible, biodegradable and nontoxic carriers, applied to encapsulate hydrophilic active substances, including probiotics. Here, we report the methods most frequently used for AMP production and encapsulation of different actives. The technological parameters important in the process of AMP preparation, such as alginate concentration, the type and concentration of other reagents (cross-linking agents, oils, emulsifiers and pH regulators), agitation speed or cross-linking time, are reviewed. Furthermore, the advantages and disadvantages of alginate microparticles as delivery systems are discussed, and an overview of the active ingredients enclosed in the alginate carriers are presented.

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Section: Cross-linking Of Alginatesmentioning

confidence: 99%

Preparation and Characteristics of Alginate Microparticles for Food, Pharmaceutical and Cosmetic Applications

2022

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“… Wu et al (2020) described the use of chemometric analysis of low-field 1H NMR Spectra for unveiling adulteration of slimming DS by pharmaceutical compounds. Avula et al (2021) described an integrated workflow for the analysis of bio-macromolecular supplements, including NMR profiling. Simmler et al (2018) proposed an NMR-based untargeted metabolomic model as a rapid, systematic, and complementary screening for the discrimination of authentic vs potentially adulterated botanicals.…”

Section: Analytical Challenges and Approaches In Characterizing Dsmentioning

confidence: 99%

Analytical Challenges and Metrological Approaches to Ensuring Dietary Supplement Quality: International Perspectives

et al. 2022

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The increased utilization of metrology resources and expanded application of its’ approaches in the development of internationally agreed upon measurements can lay the basis for regulatory harmonization, support reproducible research, and advance scientific understanding, especially of dietary supplements and herbal medicines. Yet, metrology is often underappreciated and underutilized in dealing with the many challenges presented by these chemically complex preparations. This article discusses the utility of applying rigorous analytical techniques and adopting metrological principles more widely in studying dietary supplement products and ingredients, particularly medicinal plants and other botanicals. An assessment of current and emerging dietary supplement characterization methods is provided, including targeted and non-targeted techniques, as well as data analysis and evaluation approaches, with a focus on chemometrics, toxicity, dosage form performance, and data management. Quality assessment, statistical methods, and optimized methods for data management are also discussed. Case studies provide examples of applying metrological principles in thorough analytical characterization of supplement composition to clarify their health effects. A new frontier for metrology in dietary supplement science is described, including opportunities to improve methods for analysis and data management, development of relevant standards and good practices, and communication of these developments to researchers and analysts, as well as to regulatory and policy decision makers in the public and private sectors. The promotion of closer interactions between analytical, clinical, and pharmaceutical scientists who are involved in research and product development with metrologists who develop standards and methodological guidelines is critical to advance research on dietary supplement characterization and health effects.

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A Comprehensive Workflow for the Analysis of Bio-Macromolecular Supplements: Case Study of 20 Whey Protein Products

Cited by 2 publications

References 35 publications

Preparation and Characteristics of Alginate Microparticles for Food, Pharmaceutical and Cosmetic Applications

Preparation and Characteristics of Alginate Microparticles for Food, Pharmaceutical and Cosmetic Applications

Analytical Challenges and Metrological Approaches to Ensuring Dietary Supplement Quality: International Perspectives

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