Trends of concerns from diagnosis in patients with advanced lung cancer and their family caregivers: A 2-year longitudinal study

Sato, Takashi; Fujisawa, Daisuke; Arai, Daisuke; Nakachi, Ichiro; Takeuchi, Mika; Nukaga, Shigenari; Kobayashi, Keigo; Ikemura, Shinnosuke; Terai, Hideki; Yasuda, Hiroyuki; Kawada, Ichiro; Sato, Yasunori; Satomi, Ryosuke; Takahashi, Saeko; Hashiguchi, Mizuha; Nakamura, Morio; Oyamada, Yoshitaka; Terashima, Takeshi; Sayama, Koichi; Saito, Fumitake; Sakamaki, Fumio; Inoue, Takashi; Naoki, Katsuhiko; Fukunaga, Koichi; Soejima, Kenzo

doi:10.1177/02692163211001721

Cited by 8 publications

(7 citation statements)

References 28 publications

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“…This study is part of a larger study in which various psychosocial aspects of patients with advanced lung cancer and their caregivers were assessed, and the details of the study procedure have been described elsewhere. 17,18 Patients with newly diagnosed clinical stage IIIB or IV lung cancer (defined by the seventh edition of lung cancer stage classification) who were enrolled soon after disclosure of their diagnosis, within 2 weeks in principle, between December 2013 and March 2016 at 16 hospitals in Japan where general anticancer treatments were available were asked to complete the questionnaires. Patients were eligible if they were age 20 years or older.…”

Section: Methodsmentioning

confidence: 99%

Most Important Things and Associated Factors With Prioritizing Daily Life in Patients With Advanced Lung Cancer

Kameyama

Sato

Arai

et al. 2022

JCO Oncology Practice

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PURPOSE: Patients' values and priorities in their lives should be appreciated from an early phase of incurable diseases such as advanced cancer. However, studies examining these characteristics have been lacking. This study attempted to determine what patients with advanced lung cancer valued most, once they had been diagnosed, and any associated factors. METHODS: Patients with newly diagnosed advanced lung cancer (N = 248) were enrolled in a questionnaire survey conducted at 16 hospitals in Japan. Their priorities were assessed using a free-text response to the question what is the most important thing to you now? at the time of diagnosis and 3 months after diagnosis. The free-text responses were classified into 10 categories for quantification. The clinical characteristics associated with the category describing daily life were further examined. RESULTS: Free-text comments were obtained from 103 (44.0%) and 66 (42.6%) patients at the time of diagnosis and at 3 months, respectively. The most frequent categories were family (at diagnosis: 50.5%; at 3 months: 50.0%) and daily life (at diagnosis: 33.0%; at 3 months: 36.4%), followed by health (at diagnosis: 32.0%; at 3 months: 27.3%) at both time points. The patients mentioning daily life, the issues related to how to spend daily life, showed significantly higher total scores and functional well-being subscale scores on the Functional Assessment of Cancer Therapy-Lung scale at both time points and lower depression scores at diagnosis and lower anxiety scores at 3 months on the Hospital Anxiety and Depression Scale. CONCLUSION: Family and daily life were highly valued by patients with advanced lung cancer at diagnosis. A better quality of life and better mood were associated with mentioning daily life, which should be taken into account in care planning to maintain patients' involvement in daily life even with incurable diseases.

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Section: Methodsmentioning

confidence: 99%

Most Important Things and Associated Factors With Prioritizing Daily Life in Patients With Advanced Lung Cancer

Kameyama

Sato

Arai

et al. 2022

JCO Oncology Practice

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“…Recent longitudinal studies employing either quantitative or qualitative designs showed that although the caregiver burden and unmet needs tend to vary over time, they may persist throughout the cancer illness and caregiving trajectory [ 49 , 50 •, 51 •]. Caregivers who have substantial caregiver burden and psychological distress before the initiation of treatment are likely to experience higher levels of caregiver burden and psychological distress after termination of chemotherapy [ 49 , 52 ].…”

Section: Impact Of Caregiving On Informal Cancer Caregiversmentioning

confidence: 99%

“…According to a longitudinal qualitative study, family caregivers constantly worry about the prognosis of the patient throughout the course of chemotherapy, which causes anxiety [ 50 •]. With the passage of time, caregivers gain more experience and skills for cancer caregiving [ 50 •], and their information needs tend to be met to a certain extent [ 51 •]. However, due to the emerging adverse effects of treatment and the often the progression of cancer, caregivers may need continuous support from the oncology team [ 50 •].…”

Section: Impact Of Caregiving On Informal Cancer Caregiversmentioning

confidence: 99%

Understanding and Supporting Informal Cancer Caregivers

Molassiotis

Wang

2022

Curr. Treat. Options in Oncol.

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Opinion statement Informal caregivers invest a significant amount of time and effort to provide cancer patients with physical, psychological, information, and social support. These challenging tasks can harm their own health and well-being, while a series of social-ecological factors may also influence the outcomes of cancer caregiving. Several instruments have been developed to help clinicians and researchers understand the multi-dimensional needs and concerns of caregivers. A growing body of evidence indicates that supportive interventions including psychoeducation, skills training, and therapeutic counseling can help improve the burden, information needs, coping strategies, physical functioning, psychological well-being, and quality of life of caregivers. However, there is difficulty in translating research evidence into practice. For instance, some supportive interventions tested in clinical trial settings are regarded as inconsistent with the actual needs of caregivers. Other significant considerations are the lack of well-trained interdisciplinary teams for supportive care provision and insufficient funding. Future research should include indicators that can attract decision-makers and funders, such as improving the efficient utilization of health care services and satisfaction of caregivers. It is also important for researchers to work closely with key stakeholders, to facilitate evidence dissemination and implementation, to benefit caregivers and the patient.

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“…Because of the disease trajectory of lung cancer patients, informal caregivers play a key role in caring for them [4]. Informal caregivers can assist patients with lung cancer in managing symptoms, activities of daily living, finance, transportation, seeking information, and providing psychosocial support [4][5][6][7]. Taking care of cancer patients is a tremendous burden for informal caregivers [8] and the resultant burden often leads to in physical as well as psychosocial malfunction [4,9].…”

Section: Introductionmentioning

confidence: 99%

“…Maintaining the psychological health of informal caregivers is all the more important because it is associated with the clinical health of cancer patients [7,13,14]. For example, a study of 43 lung cancer patient and caregiver dyads found that patient's symptoms were positively correlated with the caregiver's depression and anxiety [7]. Another study [15] linked higher depression scores of the patient with caregiver depression (b = 0.72, p<0.001).…”

Section: Introductionmentioning

confidence: 99%

Non-pharmacological interventions on anxiety and depression in lung cancer patients’ informal caregivers: A systematic review and meta-analysis

Lei

Lee²,

Shin³

et al. 2023

PLoS ONE

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Background Lung cancer is one of the common cancers and the leading cause of death. Tremendous caregiving burden of informal caregivers of lung cancer causes psychological disorders, such as anxiety and depression. Interventions for informal caregivers of patients with lung cancer to improve their psychological health, which ultimately leads to patients’ positive health outcomes, are crucial. A systematic review and meta-analysis was conducted to: 1) evaluate the effect of non-pharmacological interventions on the outcomes of depression and anxiety for lung cancer patients’ informal caregivers; and 2) compare the effects of interventions with differing characteristics (i.e. intervention types, mode of contact, and group versus individual delivery). Methods Four databases were searched to identify relevant studies. Inclusion criteria for the articles were peer-reviewed non-pharmacological intervention studies on depression and anxiety in lung cancer patients’ informal caregivers published between January 2010 and April 2022. Systematic review procedures were followed. Data analysis of related studies was conducted using the Review Manager Version 5.4 software. Intervention effect sizes and studies’ heterogeneity were calculated. Results Eight studies from our search were eligible for inclusion. Regarding total effect for the caregivers’ levels of anxiety and depression, results revealed evidence for significant moderate effects of intervention on anxiety (SMD -0.44; 95% CI, -0.67, -0.21; p = 0.0002) and depression (SMD -0.46; 95% CI, -0.74, -0.18; p = 0.001). Subgroup analyses for both anxiety and depression of informal caregivers revealed moderate to high significant effects for specific intervention types (cognitive behavioral and mindfulness combined with psycho-education interventions), mode of contact (telephone-based interventions), and group versus individual delivery. Conclusion This review provides evidence that cognitive behavioral and mindfulness-based, telephone-based, individual or group-based interventions were effective for informal caregivers of lung cancer patients. Further research is needed to develop the most effective intervention contents and delivery methods across informal caregivers with larger sample size in randomized controlled trials.

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Trends of concerns from diagnosis in patients with advanced lung cancer and their family caregivers: A 2-year longitudinal study

Cited by 8 publications

References 28 publications

Most Important Things and Associated Factors With Prioritizing Daily Life in Patients With Advanced Lung Cancer

Most Important Things and Associated Factors With Prioritizing Daily Life in Patients With Advanced Lung Cancer

Understanding and Supporting Informal Cancer Caregivers

Non-pharmacological interventions on anxiety and depression in lung cancer patients’ informal caregivers: A systematic review and meta-analysis

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