Ethyl pyruvate supplemented in drinking water ameliorates experimental nonalcoholic steatohepatitis

Sun, Xiujing; Zhu, Shengtao; Xiang, Dong; Strand-Amundsen, Runar; Tønnessen, Tor Inge; Yang, Runkuan

doi:10.1016/j.biopha.2021.111392

Cited by 3 publications

(1 citation statement)

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“…The inflammatory cytokines in the liver of MCD mice treated with EP in drinking water were significantly reduced, pathological characteristics of liver tissue were improved, and alanine aminotransferase level in the serum was decreased. Sun et al, 2021 active the sites of NF-κB to enter the nucleus and participate in the transcription process of inflammatory factors (Colombo et al, 2018). EP has shown its potent repressive effect on p50/p65, thus being a potential inhibitor of NF-κB (Sharma et al, 2015).…”

Section: Mao Et Al 2021mentioning

confidence: 99%

Protective role of ethyl pyruvate in spinal cord injury by inhibiting the high mobility group box-1/toll-like receptor4/nuclear factor-kappa B signaling pathway

Fan

Wang

Botchway

et al. 2022

Front. Mol. Neurosci.

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Spinal cord injury (SCI) is a high incident rate of central nervous system disease that usually causes paralysis below the injured level. The occurrence of chronic inflammation with the axonal regeneration difficulties are the underlying barriers for the recovery of SCI patients. Current studies have paid attention to controlling the instigative and developmental process of neuro-inflammation. Ethyl pyruvate, as a derivative of pyruvate, has strong anti-inflammatory and neuroprotective functions. Herein, we reviewed the recent studies of ethyl pyruvate and high mobility group box-1 (HMGB1). We think HMGB1 that is one of the main nuclear protein mediators to cause an inflammatory response. This protein induces astrocytic activation, and promotes glial scar formation. Interestingly, ethyl pyruvate has potent inhibitory effects on HMGB1 protein, as it inhibits chronic inflammatory response by modulating the HMGB1/TLR4/NF-κB signaling pathway. This paper discusses the potential mechanism of ethyl pyruvate in inhibiting chronic inflammation after SCI. Ethyl pyruvate can be a prospective therapeutic agent for SCI.

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Section: Mao Et Al 2021mentioning

confidence: 99%