A three-dimensional pinwheel-shaped paper-based microfluidic analytical device for fluorescence detection of multiple heavy metals in coastal waters by rational device design

Wang, Milan; Song, Zhihua; Jiang, Yi; Zhang, Xiaolin; Lin, Wenxian; Zhao, Hongyu; Cui, Yanxiang; Gu, Furong; Wang, Yunhua; Zheng, Guang

doi:10.1007/s00216-021-03269-9

Cited by 21 publications

(15 citation statements)

References 37 publications

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“…Thus, pump‐free microfluidics like centrifugal‐actuated (Chen, Chen et al., 2021; Maguire et al., 2018; Nguyen et al., 2019; Oh et al., 2016; Park et al., 2017; Seo et al., 2017), magnetic‐actuated (Foncy et al., 2016; Guan et al., 2022; Wei et al., 2018), and capillary‐actuated (Prasad et al., 2019; Qi et al., 2017; Qi et al., 2018; Wang, Song et al., 2021) multiplex microfluidic devices are gaining more and more attention, especially in low‐resource areas. Lab‐on‐a‐disc is a unique microfluidic platform in which the liquid manipulation is relatively simple under centrifugal pumping force.…”

Section: Strategies and Applications Of Mobas In Food Safety Analysismentioning

confidence: 99%

Multiplex optical bioassays for food safety analysis: Toward on‐site detection

Guan

Jin

et al. 2022

Comp Rev Food Sci Food Safe

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Food safety analysis plays a significant role in controlling food contamination and supervision. In recent years, multiplex optical bioassays (MOBAs) have been widely applied to analyze multiple hazards due to their efficiency and low cost. However, due to the challenges such as multiplexing capacity, poor sensitivity, and bulky instrumentation, the further application of traditional MOBAs in food screening has been limited. In this review, effective strategies regarding food safety MOBAs are summarized, such as spatial‐resolution modes performed in multi‐T lines/dots strips or arrays of strip/microplate/microfluidic chip/SPR chip and signal‐resolution modes employing distinguishable colorimetric/luminescence/fluorescence/surface plasma resonance/surface‐enhanced Raman spectrum as signal tags. Following this, new trends on how to design engineered sensor architecture and exploit distinguishable signal reporters, how to improve both multiplexing capacity and sensitivity, and how to integrate these formats into smartphones so as to be mobile are summarized systematically. Typically, in the case of enhancing multiplexing capacity and detection throughput, microfluidic array chips with multichannel architecture would be a favorable approach to overcome the spatial and physical limitations of immunochromatographic assay (ICA) test strips. Moreover, noble metal nanoparticles and single‐excitation, multiple‐emission luminescence nanomaterials hold great potential in developing ultrasensitive MOBAs. Finally, the exploitation of innovative multiplexing strategy hybridized with powerful and widely available smartphones opens new perspectives to MOBAs. In future, the MOBAs should be more sensitive, have higher multiplexing capacity, and easier instrumentation.

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Section: Strategies and Applications Of Mobas In Food Safety Analysismentioning

confidence: 99%

Multiplex optical bioassays for food safety analysis: Toward on‐site detection

Guan

Jin

et al. 2022

Comp Rev Food Sci Food Safe

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“…[ 6–13 ] In addition to medical diagnosis paper‐based microfluidic devices are used as sensors for detection of environmental pollution, [ 1,14 ] pesticide detection, [ 15 ] determination of nitrate concentration in water, [ 16 ] or as a sensor to detect heavy metals such as copper, cobalt, nickel, lead or mercury. [ 17–25 ]…”

Section: Introductionmentioning

confidence: 99%

“…[ 1,2,5,21,27,35,32,36 ] Shaping techniques are relatively expensive due to the necessary equipment. [ 10,23,35,37–39 ] Tuning fluid transport through the fiber type, fiber density, or paper grammage bares the advantage of simple integration into existing paper fabrication processes. None of these approaches allows to tune fluid flow in all three dimensions of a paper sheet, although, this would open new possibilities such as sensitivity enhancement and the design of multifunctional microfluidic paper‐based devices or asymmetric wettability for paper‐based separation and packaging.…”

Section: Introductionmentioning

confidence: 99%

“…[6][7][8][9][10][11][12][13] In addition to medical diagnosis paper-based microfluidic devices are used as sensors for detection of environmental pollution, [1,14] pesticide detection, [15] determination of nitrate concentration in water, [16] or as a sensor to detect heavy metals such as copper, cobalt, nickel, lead or mercury. [17][18][19][20][21][22][23][24][25] Fluid transport control in paper, a key feature for μPAD design, is to date achieved by either hydrophobic barrier deposition, often using wax or hydrophobic polymer such as polystyrene to adjust the channel width, or secondly by shaping of the paper fiber itself, and thirdly by adjusting the paper composition. [1,[26][27][28][29] To improve fluid mixing, wax pillars printed into the channel have been demonstrated to slow down the fluid flow and to create turbulences whereby a better mixing and distribution is achieved.…”

mentioning

confidence: 99%

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Mechanistic Understanding and Three‐Dimensional Tuning of Fluid Imbibition in Silica‐Coated Cotton Linter Paper Sheets

Mikolei

Neuenfeld

Paech

et al. 2022

Adv Materials Inter

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Intensive research has been carried out in point-of-care diagnostics (POC), in particular in the area of lateral flow assays, sensor technology, and labon-a-chip implementations. For example, different biomarkers like hormones, DNA, RNA, proteins or different metabolites, [1] including inflammatory markers such as Interleukin 8, [2,3] or cancer biomarkers in the context of an early cancer diagnosis, [4,5] as well as the concentration of glucose in blood, sweat or urine was detected. [6][7][8][9][10][11][12][13] In addition to medical diagnosis paper-based microfluidic devices are used as sensors for detection of environmental pollution, [1,14] pesticide detection, [15] determination of nitrate concentration in water, [16] or as a sensor to detect heavy metals such as copper, cobalt, nickel, lead or mercury. [17][18][19][20][21][22][23][24][25] Fluid transport control in paper, a key feature for μPAD design, is to date achieved by either hydrophobic barrier deposition, often using wax or hydrophobic polymer such as polystyrene to adjust the channel width, or secondly by shaping of the paper fiber itself, and thirdly by adjusting the paper composition. [1,[26][27][28][29] To improve fluid mixing, wax pillars printed into the channel have been demonstrated to slow down the fluid flow and to create turbulences whereby a better mixing and distribution is achieved. [30,31] In a preliminary work of our research group redox gating of fluid imbibition in silica-coated paper sheets has been demonstrated using redox-responsive polymers. These stimuli-responsive polymers allow to switch from fluid exclusion to fluid imbibition. [32] Further examples demonstrating switching from fluid exclusion to fluid imbibition use PNIPAAm as temperature-responsive coating. [33,34] These approaches differ in their applicability: Hydrophobizing agents such as wax, polystyrene or PDMS are deposited on the papers using various printing-, stamping, dipping-or spraying processes or even grafting polymerization.

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“…Microfluidic paper-based analytical devices (μPADs) have recently drawn considerable attention (Yetisen et al 2013 ; Pattanayak et al 2021 ), especially for Point-of-Care (POC) applications (Ebrahimi Fana et al 2021 ; Tseng et al 2021 ; Kishnani et al 2021 ) due to their low cost (Mai et al 2019 ; Tesfaye and Hussen 2022 ), wicking transport (Osborn et al 2010 ), low volume analysis, multiplexing (Gravesen et al 1993 ), user-friendliness (Mehrdel et al 2018 ), high efficiency (Wang et al 2020 ), and short processing time (Lopez-Ruiz et al 2014 ). Owing to their relatively simple and low-cost fabrication equipment (Koivunen et al 2016 ), μPADs have found numerous applications in autonomous technology (Patil et al 2020 ), environmental control (Wang et al 2021b ; Damodara et al 2021 ), food quality monitoring (Cinti 2019 ), development of nano-biosensors (Swain and Bhand 2021 ), and especially detection of various health-related compounds (Eisenbrand et al 1980 ; Jayawardane et al 2014 ; Sukuroglu et al 2015 ; Burleigh et al 2018 ; Kamali et al 2018 ; Kojić et al 2020 ; Ferreira et al 2021 ; Shariati and Khayatian 2022 ), particularly as a rapid, low-cost tool for screening and control of pandemics, such as COVID-19 (Lorente et al 2020 ; Verma et al 2020 ; Wang et al 2021a ).…”

Section: Introductionmentioning

confidence: 99%

Nitrite enhanced detection from saliva by simple geometrical modifications of paper-based micromixers

Mollaie

Asiaei

Aryan

2022

Microfluid Nanofluid

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Dysregulation of nitric oxide (NO) and it’s two relatively stable metabolites, nitrite, and nitrate, in SARS-CoV-2, are reported in infected populations, especially for nitrates levels > 68.4 μmol/L. In this paper, we measure the abnormal presence of nitrite in the saliva by developing a cheap μPAD for colorimetric detection through the modified Griess reaction. This includes a diazotization reaction between nitrite and Griess reagent, including Sulfanilamide and N-Naphthyl-ethylenediamine in an acidic medium, causing a pink Azo compound. The modifications are suggested by a numerical method model that couples the mass flux with the porosity medium equations (convection, diffusion and, dispersion) that improves the mixing process. The mixing index was quantified from the concentration deviation method via simulation of a homogeneous two-phase flow in a porous environment. Five μPAD designs were fabricated to verify the simulation results of mixing enhancement on the Griess reactants in saliva samples. The investigated geometries include straight, helical, zig–zag, square wave, and inclined jagged shapes fabricated by direct laser writing, suitable for low cost, mass fabrication. Inclined jagged micromixer exhibited the best performance with up to 40% improvement compared with the simple straight geometry. Deliberate geometrical modifications, exemplified here in a jagged micromixer on paper, cut the limit of detection (LOD) by at least half without impacting the linear detection range.

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A three-dimensional pinwheel-shaped paper-based microfluidic analytical device for fluorescence detection of multiple heavy metals in coastal waters by rational device design

Cited by 21 publications

References 37 publications

Multiplex optical bioassays for food safety analysis: Toward on‐site detection

Multiplex optical bioassays for food safety analysis: Toward on‐site detection

Mechanistic Understanding and Three‐Dimensional Tuning of Fluid Imbibition in Silica‐Coated Cotton Linter Paper Sheets

Nitrite enhanced detection from saliva by simple geometrical modifications of paper-based micromixers

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