Accuracy of imprint cytology and frozen section histology for intraoperative diagnosis of ovarian epithelial tumors: A comparative study and proposed algorithm

Abstract

Background Appropriate surgical treatment of epithelial ovarian tumors is reliant on intraoperative diagnosis. A retrospective study to compare the diagnostic accuracies of imprint cytology (IC) with frozen section histology (FSH) in these tumors was performed. Methods About 78 cases of IC‐based and FSH‐based diagnoses against the final histopathologic diagnoses in terms of both histologic subtype (serous, mucinous, endometrioid, or clear cell tumor) and behavioral type (benign, borderline, or malignant) were compared. The cytomorphologic features of the tumor cells (nuclear atypia, papillary clusters, adenoma cells, and necrosis) in relation to behavioral types were also evaluated. Results While the diagnostic accuracy of IC and FSH were similar with respect to behavioral type (87% and 88%, respectively), the diagnostic accuracy of IC was superior to that of FSH with respect to histologic subtype (83% and 74%, respectively). Among histopathologically confirmed malignant tumors, the diagnostic accuracy of IC (62/64; 97%) was superior to that of FSH (58/64; 91%). The presence of necrosis and absence of adenoma cells were significantly more prevalent among malignant group than among borderline and benign groups (P < .01, for both). Conclusion Since the presence of necrosis and absence of adenoma cells around the carcinoma cells appear useful in distinguishing malignant and borderline tumors, it was proposed to include IC for further intraoperative assessment of any tumors initially diagnosed as a borderline tumor by FSH.

Multivariate Discriminant Analysis on Differentiating Sheep Breeds Based on Live Body and Carcass Measurements

“…Among them, CytS is relatively easy to operate, and it is easy for pathologists to observe the clearer contours of the tumour tissue cells under the optical microscope, and the structures such as papillae and glands can be observed in the cell prints, which is beneficial to clinical diagnosis. By making multiple scrapings and prints of the tumour section, the defects in the sampling of FroS can be effectively compensated for, but a single CytS diagnosis lacks the histological structure, and the diagnostic misdiagnosis rate is relatively high if the tumour is infiltrative (Nomura et al, 2021;Mahadevappa et al, 2017). For FroS, histological structures can be clearly observed under light microscopy for histological features (Shah et al, 2019;Basaran et al, 2014).…”

Assessing the Coral Reef Fish Biodiversity in the Al-Wajh Region of the Northern Red Sea, Saudi Arabia

“…Among them, CytS is relatively easy to operate, and it is easy for pathologists to observe the clearer contours of the tumour tissue cells under the optical microscope, and the structures such as papillae and glands can be observed in the cell prints, which is beneficial to clinical diagnosis. By making multiple scrapings and prints of the tumour section, the defects in the sampling of FroS can be effectively compensated for, but a single CytS diagnosis lacks the histological structure, and the diagnostic misdiagnosis rate is relatively high if the tumour is infiltrative (Nomura et al, 2021;Mahadevappa et al, 2017). For FroS, histological structures can be clearly observed under light microscopy for histological features (Shah et al, 2019;Basaran et al, 2014).…”