Prognostic significance of lymphocyte reconstitution in the early phase after cord blood transplantation

Abstract

Data S1. Statistical methods. Table S1. Demographic data for patient cohort. Table S2. Clinical characteristics of patients transplanted in the first and second time periods of the series.

Optimal time and threshold of absolute lymphocyte count recovery as a prognostic factor after single‐unit cord blood transplantation in adults

“…Indeed, lymphocyte recovery was slower in CBT recipients compared with lymphocyte recovery in matched unrelated adult donor recipients at early time‐points [ 15 ]. Most studies have evaluated the impact of ALC at 30–50 days even after CBT [ 1 , 2 , 3 , 4 ]. However, our data showed that ALC values determined at 60 days could stratify survival and NRM following CBT.…”

“…Delayed immune reconstitution is one of the major limitations of cord blood transplantation (CBT). Previous studies clearly demonstrated that absolute lymphocyte count (ALC) recovery, which may be a useful surrogate marker of immune reconstitution, predicted survival following CBT [1–4] as well as allogeneic hematopoietic cell transplantation (HCT) from adult donors [5,6]. However, various thresholds and time points of ALC recovery following CBT have been reported to be prognostic factors for CBT [1–4].…”

“…Previous studies clearly demonstrated that absolute lymphocyte count (ALC) recovery, which may be a useful surrogate marker of immune reconstitution, predicted survival following CBT [ 1 , 2 , 3 , 4 ] as well as allogeneic hematopoietic cell transplantation (HCT) from adult donors [ 5 , 6 ]. However, various thresholds and time points of ALC recovery following CBT have been reported to be prognostic factors for CBT [ 1 , 2 , 3 , 4 ]. Therefore, we evaluated the optimal time and threshold of ALC recovery as a prognostic factor following CBT.…”