Pulmonary artery trunk enlargement on admission as a predictor of mortality in in-hospital patients with COVID-19

Zhu, Qingqing; Gong, Tao; Huang, Guoquan; Niu, Zhiwei; Yue, Ting; Xu, Fangyi; Chen, Chao; Wang, Guangbin

doi:10.1007/s11604-021-01094-9

Cited by 16 publications

(16 citation statements)

References 15 publications

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“…However, in the present study, the effect of MPAD increase on mortality was examined without using a cut-off value. In addition, the mortality rates in the present study were quite high compared to those in the study by QQ Zhu et al (16) (64.1% vs. 7.8%) due to the high mean age of the patients included in the present study (69.82 years vs. 46.99 years) and the patients requiring intensive care treatment.…”

Section: Discussioncontrasting

confidence: 66%

The effect of main pulmonary artery diameter on the prognosis of COVID-19 patients in the ICU

ÇORAPLI>

Çil

Tutak

et al. 2022

Journal of Health Sciences and Medicine

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Aim: The aim of this study was to examine the effect of main pulmonary artery diameter (MPAD), which is evaluated in patients when first admitted to the intensive care unit due to COVID-19, on mortality. Material and Method: Thoracic computed tomography examinations performed during the initial admission to hospital of patients who were treated in the intensive care unit between October 1, 2020, and June 1, 2021, were evaluated retrospectively. Cox regression analysis was performed with the program R-Project to evaluate the relationship between MPAD and mortality. Results: No significant correlation was found between MPAD and mortality in models used with or without adjusting for age and sex (respectively P: 0.890 and P: 0.920). Conclusion: The MPAD value measured at the initial admission of COVID-19 patients hospitalized in the intensive care unit is not a parameter that can be used to predict mortality.

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Section: Discussioncontrasting

confidence: 66%

The effect of main pulmonary artery diameter on the prognosis of COVID-19 patients in the ICU

ÇORAPLI>

Çil

Tutak

et al. 2022

Journal of Health Sciences and Medicine

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“…On the other hand, TIB was associated with a significantly increased prevalence of pulmonary artery dilatation, a radiologic sign recently recognized as a predictor of clinical severity and mortality in COVID-19 patients [ 25 , 26 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical implications of microvascular CT scan signs in COVID-19 patients requiring invasive mechanical ventilation

et al. 2022

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Purpose COVID-19-related acute respiratory distress syndrome (ARDS) is characterized by the presence of signs of microvascular involvement at the CT scan, such as the vascular tree in bud (TIB) and the vascular enlargement pattern (VEP). Recent evidence suggests that TIB could be associated with an increased duration of invasive mechanical ventilation (IMV) and intensive care unit (ICU) stay. The primary objective of this study was to evaluate whether microvascular involvement signs could have a prognostic significance concerning liberation from IMV. Material and methods All the COVID-19 patients requiring IMV admitted to 16 Italian ICUs and having a lung CT scan recorded within 3 days from intubation were enrolled in this secondary analysis. Radiologic, clinical and biochemical data were collected. Results A total of 139 patients affected by COVID-19 related ARDS were enrolled. After grouping based on TIB or VEP detection, we found no differences in terms of duration of IMV and mortality. Extension of VEP and TIB was significantly correlated with ground-glass opacities (GGOs) and crazy paving pattern extension. A parenchymal extent over 50% of GGO and crazy paving pattern was more frequently observed among non-survivors, while a VEP and TIB extent involving 3 or more lobes was significantly more frequent in non-responders to prone positioning. Conclusions The presence of early CT scan signs of microvascular involvement in COVID-19 patients does not appear to be associated with differences in duration of IMV and mortality. However, patients with a high extension of VEP and TIB may have a reduced oxygenation response to prone positioning. Trial Registration : NCT04411459 Supplementary Information The online version contains supplementary material available at 10.1007/s11547-021-01444-7.

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“…A study conducted by Esposito et al, which included 1461 patients, determined that an MPAD ≥ 31 mm in COVID-19 patients was an independent predictor of mortality (15). The study by Zhu et al demonstrated that MPAD ≥ 29 mm is a significant predictor of mortality (10). Truong et al demonstrated that the predictive value of MPAD of 31 mm or greater in diagnosis PH and associated with 2-3 fold increased mortality risk compared to normal (11).…”

Section: Discussionmentioning

confidence: 99%

“…CT is widely used, especially in the emergency department, to make a risk assessment, and evaluate lung involvement and differential diagnosis. PA enlargement is a predictor of hemodynamic instability such as; right ventricular failure, pulmonary hypertension (PH), and embolism (9,10,11). Although PA dilatation reflects vascular injury, abnormal coagulation, hypoxia, and inflammation, the optimal cut-off value of PA diameter in COVID-19 patients is unknown.…”

Section: Introductionmentioning

confidence: 99%

Pulmonary artery diameter on chest CT predicts in-hospital mortality in patients with COVID-19 pneumonia

Baytugan¹,

Aziz²,

Bezgin³

2022

Sanamed

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Background: Enlargement of the pulmonary artery (PA) could be helpful in risk stratification by the chest CT on the admission of COVID-19 patients. Methods: This study aimed to associate PA diameter and overall mortality in COVID-19 pneumonia. We designed a retrospective study between January 2021 and May 2021 in tertiary-level hospitals in Gebze, Turkey. Subjects were evaluated in two groups according to their survivor status (survivors and non-survivors). Then biochemical, demographic, and clinical values were compared via the groups to define the predictive value of PA diameter on chest CT images. Results: In the enrolled 594 COVID-19 in-hospital patients (median age was 45 (34-58) years, 263patients (44.3%) were female. 44 patients (7.4%) died during hospitalization. Multivariate Cox-proportion regression model yielded main PA ≥ 29 mm on admission showed that as independent predictors of death (long rank <0.001, median survival time 28 days). Cumulative survival rates were MPAD ≥ 29 mm 45% and < 29 mm 90% yielded (p < 0.001) Conclusions: PA dilatation is strongly linked with in-hospital mortality in hospitalized patients with COVID-19 infection. Thus increased PA diameter on chest CT at admission may guide rapid and early diagnosis of high-risk patients.

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Pulmonary artery trunk enlargement on admission as a predictor of mortality in in-hospital patients with COVID-19

Cited by 16 publications

References 15 publications

The effect of main pulmonary artery diameter on the prognosis of COVID-19 patients in the ICU

The effect of main pulmonary artery diameter on the prognosis of COVID-19 patients in the ICU

Clinical implications of microvascular CT scan signs in COVID-19 patients requiring invasive mechanical ventilation

Pulmonary artery diameter on chest CT predicts in-hospital mortality in patients with COVID-19 pneumonia

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