Sepsis Following Liver Biopsy in a Liver Transplant Recipient: Case Report and Review of Literature

Abstract

Percutaneous liver biopsy is a relatively safe procedure with low complication rates. Infections following liver biopsy are uncommon and can lead to a poor outcome. There are limited data on liver biopsy-related infections among liver transplant (LT) recipients. Also, there is a paucity of data regarding the use of prophylactic antibiotics in LT patients undergoing percutaneous liver biopsy. We report a case of systemic sepsis following percutaneous liver biopsy in a LT recipient with choledochojejunal anastomosis. This was followed by severe rejection and deterioration of liver function and recurrence of primary sclerosing cholangitis (PSC) to the extent that he has been listed for retransplantation. This case report emphasizes the potential risk of sepsis in LT recipients with bilioenteric anastomosis undergoing percutaneous liver biopsy. This increased risk may warrant periprocedural broad spectrum antibiotic prophylaxis, in this subgroup of patients.

N6-methyladenosine (m6A) methyltransferase METTL3 regulates sepsis-induced myocardial injury through IGF2BP1/HDAC4 dependent manner

“…Sepsis is a common clinical complication and considered to be an abnormal inflammatory response caused by infection, which subsequently leads to multiple organ failure [ 1 , 2 ]. In the pathophysiology of sepsis, aberrant inflammation and immune response can aggravate the sepsis, leading to shock or myocardial dysfunction [ 3 , 4 ].…”