Nifuroxazide improves insulin secretion and attenuates high glucose-induced inflammation and apoptosis in INS-1 cells

Liu, Jingyi; Zhang, Yichen; Xie, Ri-hua; Song, Li-Ni; Yang, Weili; Zhong, Xin; Cao, Xi; Yang, Jin-Kui

doi:10.1016/j.ejphar.2021.174042

Cited by 13 publications

(6 citation statements)

References 41 publications

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“…The reason may be related to the fact that the glucose concentration of 4.5 g/L is higher than the normal blood glucose concentration in vivo when the carbon source is not depleted ( Li et al., 2022 ). Besides, 1 g/L was also used in many SC studies as the control group ( Yuan et al., 2022 ; Liu et al., 2021 ). Therefore, we think it is more reasonable to use 1 g/L as the control in the subsequent experiment.…”

Section: Discussionmentioning

confidence: 99%

Schwann cells-derived exosomal miR-21 participates in high glucose regulation of neurite outgrowth

et al. 2022

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Section: Discussionmentioning

confidence: 99%

Schwann cells-derived exosomal miR-21 participates in high glucose regulation of neurite outgrowth

et al. 2022

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“…Numerous published data have documented the anti-cancer activity of nifuroxazide and nitrofuran derivatives [7,8]. In addition, the possible use of nifuroxazide in the treatment of some inflammatory diseases was also reported [9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Directional Hemispherical Reflectance in the Analysis of Expired and Unexpired Tablets Containing Nifuroxazide—The Results of a Pilot Study

Sarecka-Hujar

Szulc-Musioł

2022

The 1st International Electronic Conference on Processes: Processes System Innovation

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“…In addition, the anti-cancer activity of nifuroxazide and nitrofuran derivatives has also been documented [12]. It can also be used in the treatment of some inflammatory diseases [13,14].…”

Section: Introductionmentioning

confidence: 99%

The Use of Novel, Rapid Analytical Tools in the Assessment of the Stability of Tablets—A Pilot Analysis of Expired and Unexpired Tablets Containing Nifuroxazide

Sarecka-Hujar

Szulc-Musioł²,

Meisner³

et al. 2022

Processes

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In the analysis of finished pharmaceutical products, numerous innovative analytical techniques are often used, i.e., Raman spectroscopy, scanning electron microscopy, computer microtomography, directional hemispherical reflectance, and hyperspectral analyses. These techniques allow for the identification of changes in solid phases. Many advantages over other techniques can be attributed to these techniques, e.g., they are rapid, non-destructive, and comprehensive. They allow for the identification of changes occurring in solid phases. However, the above-mentioned methods are still not standard procedures in pharmaceutical research. The present study aimed to assess the possible usefulness of total directional hemispherical reflectance (THR), hyperspectral imaging, and computer microtomography to evaluate the stability of tablets containing nifuroxazide during storage. In the study, expired and unexpired coating tablets containing nifuroxazide (n = 10 each) were analyzed. In addition, four unexpired tablets were stored at 40°C over 3 months (stressed tablets). Reflectance was determined with seven wavelength bands from 335 nm to 2500 nm using an SOC-410 Directional Hemispherical Reflectometer (Surface Optics Corporation, San Diego, CA, USA). A Specim IQ hyperspectral camera (Spectral Imaging Ltd., Oulu, Finland) was used with a wavelength range of 400–1030 nm. Tablets were also scanned using X-ray microtomography (Phoenix vǀtomeǀx, GE Sensing & Inspection Technologies GmbH, Wunstorf, Germany). The results indicated that total reflectance was lower in expired tablets than in unexpired tablets in all spectral bands, except for 700–1100 nm and 1700–2500 nm. In turn, the stressed tablets showed higher THR values than expired tablets in all spectral bands, except for 1000–1700 nm. In addition, hyperspectral analysis of the homogeneity of the tablets, as well as X-ray microtomographic analysis of tablet density and coating thickness, indicated that these parameters differed significantly between the analyzed tablets.

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Nifuroxazide improves insulin secretion and attenuates high glucose-induced inflammation and apoptosis in INS-1 cells

Cited by 13 publications

References 41 publications

Schwann cells-derived exosomal miR-21 participates in high glucose regulation of neurite outgrowth

Schwann cells-derived exosomal miR-21 participates in high glucose regulation of neurite outgrowth

Directional Hemispherical Reflectance in the Analysis of Expired and Unexpired Tablets Containing Nifuroxazide—The Results of a Pilot Study

The Use of Novel, Rapid Analytical Tools in the Assessment of the Stability of Tablets—A Pilot Analysis of Expired and Unexpired Tablets Containing Nifuroxazide

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