Health benefits of cyanidin-3-glucoside as a potent modulator of Nrf2-mediated oxidative stress

Rahman, Sofia; Mathew, Shimy; Nair, P. N. M.; Ramadan, Wafaa; Vazhappilly, Cijo George

doi:10.1007/s10787-021-00799-7

Cited by 55 publications

(41 citation statements)

References 118 publications

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“…The effects of cyanidin 3-glucoside on hydrogen peroxide or TNF-induced insulin resistance were found to be dose-dependent. The intracellular development of ROS and the activation of Jun N-terminal kinases were reduced when adipocytes cells were pretreated with cyanidin 3-glucoside [62].…”

Section: Cyanidinsmentioning

confidence: 98%

Antioxidants: Pharmacothearapeutic Boon for Diabetes

Suresh¹,

Reddy²,

Muthukumar³

et al. 2021

Antioxidants - Benefits, Sources, Mechanisms of Action

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Glucose-induced oxidative stress can be found related to “glucose variability” and “glucose memory”. The irregular low and elevated glucose conditions cause damage to endothelial cell function than a steady, constant rise in level of glucose. Activation of PKC, NADPH oxidases, and mitochondrial oxidants are some of the pathways exhibited as a result of this aggravated cellular response. Regarding glucose memory, long after the normalization elevated level of glucose in the endothelial cells of diabetic rats and culture, a existance or ‘memory’ of induced basement membrane mRNA is expressed. This demonstrates that glucose causes dangerous long-term effects beyond the hyperglycemia period. Oxidative stress give rise to glucotoxicity and lipotoxicity which are phenomena’s related to diabetes. Following the pathogenesis of diabetes, hyperglycemia and hyperlipidemia exerts a supplementary toxic effect on the beta-cells. So, hyperglycemia can be considered as a requirement for the destructive effects of lipotoxicity. Thus glucolipotoxicity can be considered as a substitute for lipotoxicity which relates the detrimental correlation between lipids and beta-cell function. Generally, the antioxidant pharmacotherapy can be coupled with drugs to boost the natural cellular defense mechanisms as the naturally existing antioxidant components, which neutralizes free radical damage. This considers antioxidant a boon tool for pharmacotherapeutic agent.

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Section: Cyanidinsmentioning

confidence: 98%

Antioxidants: Pharmacothearapeutic Boon for Diabetes

Suresh¹,

Reddy²,

Muthukumar³

et al. 2021

Antioxidants - Benefits, Sources, Mechanisms of Action

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show abstract

“…Recent research and clinical trials have identified the beneficial effects of a plant-based diet to increase bacterial diversity and ameliorate various disorders, including intestinal disorders, obesity-related endotoxemia, and cardiovascular disorders (Vazhappilly et al, 2019[ 22 ], 2021[ 21 ]; Guglielmetti et al, 2020[ 9 ]). Fruits and berries are rich in polyphenols and modulate gut microbiota by increasing the global fecal bacteria (Klinder et al, 2016[ 13 ]; Moreno-Indias et al, 2016[ 16 ]; Teixeira et al, 2017[ 20 ]; Ntemiri et al, 2020[ 17 ]; Rahman et al, 2021[ 19 ]). For instance, in obese and overweight people, a change in the gut microbiota, with a consequent decrease in endotoxemia, through probable modulation of the Faecalibacterium , Odoribacter , and Parvimonas , was noted on consuming pomegranate extract (González-Sarrías et al, 2018[ 7 ]).…”

Section: ⁯⁯mentioning

confidence: 99%

Plant polyphenols effect on gut microbiota: Recent advancements in clinical trials

Chelakkot¹,

Vazhappilly²

2021

EXCLI Journal; 20:Doc1091; ISSN 1611-2156

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“…In particular, it exerts anti-in ammatory effects through the downregulation of different pro-in ammatory cytokines (Gupta et al, 2014;Kumar et al, 2017) and modulation of transcription factors (Hassan et al, 2019;Zhou et al, 2020), including elevation of the nuclear factor-erythroid 2 related factor 2 (Nrf2) (Hassan et al, 2019). Under physiological conditions, Nrf2 is anchored with the cytoplasmic Kelch-like ECH-associated protein 1 (Keap1), which mediates degradation by ubiquitination (Bellezza et al, 2018;Rahman et al, 2021). In response to stress, Nrf2 dissociates from Keap1 and translocates into the nucleus, where it binds to the antioxidant-response element, regulating the expression of various defensive genes involved in anti-oxidation and anti-in ammation (Bellezza et al, 2018;Rahman et al, 2021;Yang et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

“…Under physiological conditions, Nrf2 is anchored with the cytoplasmic Kelch-like ECH-associated protein 1 (Keap1), which mediates degradation by ubiquitination (Bellezza et al, 2018;Rahman et al, 2021). In response to stress, Nrf2 dissociates from Keap1 and translocates into the nucleus, where it binds to the antioxidant-response element, regulating the expression of various defensive genes involved in anti-oxidation and anti-in ammation (Bellezza et al, 2018;Rahman et al, 2021;Yang et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

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Curcumin prevents sickness behavior and fever by the modulation of Nrf2 activity in a model of endotoxemia

Reis¹,

Oliveira²,

Rojas³

et al. 2021

Preprint

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Lipopolysaccharide (LPS) is a potent inducer of inflammation, triggering behavioral changes and fever. The present study aimed to evaluate whether pretreatment with curcumin prevents the behavioral changes and fever induced by LPS through the modulation of nuclear factor-erythroid 2 related factor 2 (Nrf2). Male Wistar rats were pretreated for 2 consecutive days with vehicle or curcumin at doses of 25, 50, or 100 mg/kg by oral gavage. The animals intraperitoneally received either vehicle or LPS at a dose of 500 µg/kg. After 2 h, the behavioral responses were assessed through open field test (OFT), social interaction test, forced swim test (FST), and food intake assessment. The febrile response was assessed by telemetry after vehicle or LPS injection to evaluate the effect of curcumin on the thermoregulatory response during the immunological challenge. The pretreatment with curcumin at doses of 50 and 100 mg/kg prevented the reduction of distance traveled on OFT, increased the immobility time of FST, impaired social withdrawal, decreased food intake, and induced fever. In addition, at these doses, it was possible to observe a significant decrease in the plasma levels of TNF-α and IL1-β and an increase in Nrf2 translocation to the cell nucleus during the immunological challenge. Our data provide further evidence of curcumin's ability to prevent LPS-induced sickness behavior and fever possibly by a mechanism related to the modulation of Nrf2 translocation.

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Health benefits of cyanidin-3-glucoside as a potent modulator of Nrf2-mediated oxidative stress

Cited by 55 publications

References 118 publications

Antioxidants: Pharmacothearapeutic Boon for Diabetes

Antioxidants: Pharmacothearapeutic Boon for Diabetes

Plant polyphenols effect on gut microbiota: Recent advancements in clinical trials

Curcumin prevents sickness behavior and fever by the modulation of Nrf2 activity in a model of endotoxemia

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