Inflammation and reproductive function in women with polycystic ovary syndrome

Veléz, Leandro Martín; Seldin, Marcus M.; Motta, Alicia Beatriz

doi:10.1093/biolre/ioab050

Cited by 58 publications

(54 citation statements)

References 162 publications

(221 reference statements)

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“…Based on the above results, it is speculated that in PCOS, gut dysbacteriosis causes a systemic inflammatory response by affecting gut permeability changes, and then leads to the pathogenesis and progression of PCOS. In addition, inflammatory molecules can also serve as biomarkers for PCOS (Velez et al, 2021), which can aid in the diagnosis of the disease.…”

Section: Discussionmentioning

confidence: 99%

Alterations of Gut Microbiome and Fecal Fatty Acids in Patients With Polycystic Ovary Syndrome in Central China

Liu

Ren

et al. 2022

Front. Microbiol.

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ObjectiveThe purpose of this study was to elucidate the characteristics of the gut microbiome in patients with Polycystic ovary syndrome (PCOS) and analyze the alterations of fecal fatty acid metabolism, so as to further provide the pathogenesis of PCOS.MethodsFecal samples from the PCOS group (n = 31) and healthy control group (n = 27) were analyzed by 16S rRNA gene sequencing and untargeted metabolomics. Peripheral venous blood was collected to measure serum inflammation and intestinal permeability. Finally, the correlation analysis of intestinal flora, fecal metabolites, and laboratory indicators was carried out.ResultsSerum D-lactate content in the PCOS group was higher than that in the control group. There was no significant difference in microbial α diversity and β diversity between PCOS patients and healthy controls. Peptostreptococcaceae and Bacteroidales S24-7 group existed significant differences between PCOS patients and healthy controls. Based on linear discriminant analysis selection, 14 genera including Klebsiella, Enterobacteriaceae, and Gammaproteobacteria were dominant in patients with PCOS, while 4 genera, including rumenococcus (Ruminocaccaceae UCG 013), prewortella (Prevotellaceae UCG 001), and erysipelas (Erysipelatoclostridium), were dominant in healthy controls. Compared with PCOS with Body mass index (BMI) < 24, patients with BMI ≥ 24 have multiple dominant genera including Abiotrophia and Peptostreptococcaceae. Moreover, serum levels of free testosterone and androstenedione were positively correlated with Megamonas, while total testosterone was negatively correlated with Alistipes. Additionally, fecal contents of acetic acid and propionic acid in patients with PCOS were significantly higher than those in healthy controls. Eubacterium_coprostanoligenes_group and Alistipes were positively correlated with 6 kinds of fatty acids.ConclusionSpecific intestinal flora fecal fatty acids and serum metabolites may mediate the occurrence and development of PCOS. PCOS patients with different body sizes have specific intestinal flora.

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Section: Discussionmentioning

confidence: 99%

Alterations of Gut Microbiome and Fecal Fatty Acids in Patients With Polycystic Ovary Syndrome in Central China

Liu

Ren

et al. 2022

Front. Microbiol.

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“…Fatty liver disease is closely associated with chronic systemic and local inflammation [ 40 ]. In women with polycystic ovary syndrome, a chronic ovarian pro-inflammatory state resulted in ovarian dysfunction [ 41 ]. In laying hens, the development of polycystic ovaries with cancer was related to chronic inflammation in the ovary [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Chitosan Oligosaccharide on Production Performance, Egg Quality and Ovarian Function in Laying Hens with Fatty Liver Syndrome

Feng

Fan

Zhao

et al. 2022

Animals

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This study aimed to investigate the role of chitosan oligosaccharide (COS) as an additive in the feed of laying hens with fatty liver syndrome (FLS). Effects on production performance, egg quality as well as ovarian function were determined. A total of 360 Lohmann Pink-shell laying hens (28 weeks old) were randomly assigned to 5 groups (6 replicates × 12 birds). Hens were fed with a basal diet and a high-energy low-protein (HELP) diet supplemented with 0, 200, 400 and 800 mg/kg COS. COS reversed the lowered laying rates, increased feed-to-egg ratios and decreased albumen heights and Haugh units induced by the HELP diet. Additionally, COS improved the ovarian morphologies damaged by the HELP diet. Furthermore, COS enhanced antioxidant enzyme activities, reduced malonaldehyde levels and downregulated the mRNA expressions of nuclear factor kappa B, pro-inflammation cytokine genes and pro-apoptosis-related genes, while it upregulated the mRNA expression of anti-apoptosis-related genes in the ovaries of HELP-diet-fed hens. These findings suggested that dietary COS supplementation could improve production performance and egg quality in laying hens with FLS, and these beneficial effects were linked to improved ovarian morphology, which was attributed to decreased oxidative stress, inflammation and apoptosis in the ovaries.

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“… 75 Ovaries from PCOS patients have an increased number of inflammatory cells (lymphocytes and macrophages) suggesting persistent pro-inflammatory state, whereas obese PCOS patients were found to have pronounced pro-inflammatory levels in granulosa cells. 76 - 78 Collectively, a high prevalence of obesity among patients with PCOS poses a significant contributing factor for inducing and maintaining a proinflammatory state. Until recently, there has been little information with regard to the relationship between plasma CRP and the KP.…”

Section: Metabolic Dysfunction In Pcos and The Kpmentioning

confidence: 99%

The Kynurenine Pathway and Polycystic Ovary Syndrome: Inflammation as a Common Denominator

Jovanovic¹,

Sudhakar²,

Knezevic

2022

Int J�Tryptophan�Res

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Polycystic ovary syndrome (PCOS) is a complex metabolic disorder commonly seen in females of reproductive age. The pathophysiology of PCOS is multifactorial and includes dysfunction in ovarian steroidogenesis and folliculogenesis, impaired gonadotropin levels, insulin resistance, gut microbiota imbalance, genetic predisposition, and lifestyle preferences. Low-grade inflammatory conditions such as obesity and impaired glucose tolerance are common metabolic disturbances in women with PCOS. A growing body of literature suggests strong evidence rendering PCOS in close proximity with chronic inflammation as documented by high levels of serum white blood cells, C-reactive protein, and various proinflammatory cytokines seen in this condition. Inflammation seems to be the most common metabolic denominator between the kynurenine pathway and PCOS. The association of tryptophan and kynurenine pathway has already been well documented in mood disorders, neurodegenerative diseases, chronic pain conditions, and different inflammatory states. In this manuscript, we describe the influence of sex steroid hormones on different enzymes of the KP; inflammatory nature of PCOS and CRP as a marker of IDO/TDO activity; and the effects of altered gut flora in women with PCOS. This review provides a novel view of the available evidence of tryptophan and downstream metabolites in PCOS in the context of underlying inflammation.

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Inflammation and reproductive function in women with polycystic ovary syndrome

Cited by 58 publications

References 162 publications

Alterations of Gut Microbiome and Fecal Fatty Acids in Patients With Polycystic Ovary Syndrome in Central China

Alterations of Gut Microbiome and Fecal Fatty Acids in Patients With Polycystic Ovary Syndrome in Central China

Effects of Chitosan Oligosaccharide on Production Performance, Egg Quality and Ovarian Function in Laying Hens with Fatty Liver Syndrome

The Kynurenine Pathway and Polycystic Ovary Syndrome: Inflammation as a Common Denominator

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