Weight Regain and Breast Cancer–Related Biomarkers Following an Exercise Intervention in Postmenopausal Women

Gonzalo‐Encabo, Paola; McNeil, Jessica; Pérez-López, Alberto; Valadés, David; Courneya, Kerry S.; Friedenreich, Christine M.

doi:10.1158/1055-9965.epi-20-1652

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(2 citation statements)

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“…Since these metabolic hormones are mainly released by adipose tissue, it has been reported that reductions in adiposity may be needed to reduce these biomarkers 32 . Previous studies in breast cancer survivors and breast cancer prevention have found strong associations between changes in MetS‐associated biomarkers and adiposity changes 24,38 . Our study found that after 8 weeks of HIIT, improvements in these biomarkers were independent of body composition changes in women undergoing breast cancer treatment.…”

Section: Discussionsupporting

confidence: 53%

“…36 We found significant reductions in CRP after HIIT. Additionally, MetS and hyperinsulinemia are associated with high levels of leptin and low levels of adiponectin, 37 which increased breast cancer cell growth and may increase breast cancer recurrence. 32 The HIIT intervention provides evidence of the effects of HIIT in reducing leptin and increasing adiponectin levels during breast cancer treatment.…”

Section: Discussionmentioning

confidence: 99%

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High‐intensity interval training improves metabolic syndrome in women with breast cancer receiving Anthracyclines

Gonzalo‐Encabo

Christopher

Lee

et al. 2022

Scandinavian Med Sci Sports

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Introduction Anthracycline chemotherapy is a frequent treatment for breast cancer, whereas it can increase risk of physiologic side‐effects, such as metabolic syndrome (MetS). Exercise has been used as a non‐pharmacological strategy to decrease MetS. Specifically, high‐intensity interval training (HIIT) has been shown to improve MetS in patients with diabetes or cardiac rehabilitation patients; however, the effects of HIIT on MetS and associated biomarkers in patients with breast cancer receiving anthracycline chemotherapy have not been previously explored. Therefore, we purposed to determine the effects of HIIT on MetS in breast cancer patients undergoing anthracycline chemotherapy. Methods In total, 30 patients with breast cancer were recruited prior to initiating treatment and randomized into HIIT (n = 15) or control (n = 15). The HIIT group attended supervised cycling sessions 3 days/week for 8 weeks. MetS was assessed by waist circumference, blood pressure, fasting levels of high‐density lipoprotein cholesterol (HDL–C), triglycerides, and glucose. Circulating levels of MetS‐related biomarkers were also measured (total cholesterol, insulin, HbA1c, leptin, adiponectin, and c‐reactive protein). Results After 8 weeks, MetS z‐score was significantly improved in the HIIT group compared with controls (−7.60, 95% CI: −9.08 to −6.13, p < 0.001). MetS variables (HDL–C, glucose, and triglycerides) and circulating levels of MetS‐related biomarkers were significantly improved in the HIIT group compared with controls (p < 0.001). Non‐significant differences were found in body composition outcomes at the end of the study. Conclusions HIIT may be an effective strategy to improve MetS in breast cancer patients undergoing anthracycline chemotherapy. Furthermore, changes in MetS were independent of changes in body composition.

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Section: Discussionsupporting

confidence: 53%