The relationship of oleic acid/albumin molar ratio and clinical outcomes in leptospirosis

Martins, Caroline Azevedo; Santos, Maria C. B.; Gonçalves-de-Albuquerque, Cassiano Felippe; Castro‐Faria‐Neto, Hugo C.; Castro-Faria, Mauro Velho; Burth, Patrícia; Younes-Ibrahim, Mauricio

doi:10.1016/j.heliyon.2021.e06420

Cited by 4 publications

(3 citation statements)

References 51 publications

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“…In addition, NEFA can activate toll-like receptors and inhibit Na+/K+-ATPase, causing lung injury and edema (249, 250). Our group showed a relationship between the oleic acid/albumin molar ratio and clinical outcomes in critically ill patients, with a higher ratio indicating higher mortality in these patients (251). Omega-9 treatment increases CPT1A mRNA in the livers of septic mice, reduces plasma NEFA levels, and improves survival and clinical status (105).…”

Section: Hepatic Dysfunction During Sepsismentioning

confidence: 91%

Lipid oxidation dysregulation: an emerging player in the pathophysiology of sepsis

Muniz-Santos,

Lucieri-Costa,

Almeida

et al. 2023

Front. Immunol.

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Sepsis is a life-threatening organ dysfunction caused by abnormal host response to infection. Millions of people are affected annually worldwide. Derangement of the inflammatory response is crucial in sepsis pathogenesis. However, metabolic, coagulation, and thermoregulatory alterations also occur in patients with sepsis. Fatty acid mobilization and oxidation changes may assume the role of a protagonist in sepsis pathogenesis. Lipid oxidation and free fatty acids (FFAs) are potentially valuable markers for sepsis diagnosis and prognosis. Herein, we discuss inflammatory and metabolic dysfunction during sepsis, focusing on fatty acid oxidation (FAO) alterations in the liver and muscle (skeletal and cardiac) and their implications in sepsis development.

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Section: Hepatic Dysfunction During Sepsismentioning

confidence: 91%

Lipid oxidation dysregulation: an emerging player in the pathophysiology of sepsis

Muniz-Santos,

Lucieri-Costa,

Almeida

et al. 2023

Front. Immunol.

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“…[39,40]. Its main characteristic is its specificity for the Na/K-ATPase pump [41] on the cytosolic surface of cell membranes through the action of its lipid component on the cell membrane (oleic acid), and the poor adsorption of the albumin toward these fatty acids [42][43][44]. Synergistic inhibition reduces the co-transport activity of the Na/K-ATPase pump, increasing affinity for sodium and potassium loss [45,46].…”

Section: Pathophysiology Of Leptospirosis and Acute Kidney Injurymentioning

confidence: 99%

Acute Kidney Injury Associated with Severe Leptospirosis: Fatal Re-Emerging Disease in Latin America

Osorio-Rodríguez,

Rodelo-Barrios,

Rebolledo-Maldonado

et al. 2024

Kidney and Dialysis

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Leptospirosis is a re-emerging zoonotic disease that has had an unprecedented impact on most health systems in the world. The spectrum of symptoms is variable and usually ranges from asymptomatic cases to severe manifestations involving multiple organ dysfunction accompanied by jaundice, hemorrhage, meningitis, and acute kidney injury that requires the need for intensive care assistance. Although early antibiotic treatment is usually effective, in severe cases, it may require renal replacement therapy, invasive mechanical ventilation, vasoactive support, and invasive hemodynamic monitoring, increasing the risk of death. In Latin America, the real burden of acute kidney injury in this condition is unknown and may be underestimated due to the rapid progression of the disease, similar to other vector zoonoses, and the low coverage of diagnostic tests in primary care, especially in rural regions. Therefore, below, we review the clinical aspects and describe the scientific, clinical, and therapeutic evidence of acute kidney injury attributed to Leptospira spp. and its relevance in patients with severe leptospirosis in Latin America.

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“…The relationship of oleic acid/albumin and the reestablishment to near control values was shown in preliminary studies to be an excellent parameter indicating leptospirosis patient recovery, demonstrating its potential as a prognostic biomarker factor for leptospirosis outcomes [ 94 ]. Due to its importance, a new test adapting three different methodologies to provide information concerning albumin–NEFA saturation determined by albumin isoelectric focusing and staining with bromocresol green was developed, providing an alternative to the current methodology for serum NEFA quantification with the advantage of measuring albumin’s ability to bind NEFA [ 95 , 96 ].…”

Section: Organ Impact Of Molecular Mechanismsmentioning

confidence: 99%

Cellular Pathophysiology of Leptospirosis: Role of Na/K-ATPase

Gonçalves-de-Albuquerque

Cunha

Castro

et al. 2023

Microorganisms

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Inada and Ido identified Leptospira sp. as the pathogen responsible for Weil’s Disease in 1915. Later, it was confirmed that Leptospira causes leptospirosis. The host microorganism’s interaction at the cellular level remained misunderstood for many years. Although different bacterial components have been isolated and purified, the complexity of the molecular interactions between these components and the host and the molecular mechanisms responsible for the systemic dysfunctions still needs to be fully unveiled. Leptospirosis affects virtually all animal species. Its cellular pathophysiology must involve a ubiquitous cellular mechanism in all eukaryotes. Na/K-ATPase is the molecular target of the leptospiral endotoxin (glycolipoprotein—GLP). Na/K-ATPase dysfunctions on different types of cells give rise to the organ disorders manifested in leptospirosis. Concomitantly, the development of a peculiar metabolic disorder characterized by dyslipidemia, with increased levels of circulating free fatty acids and an imbalance in the fatty acid/albumin molar ratio, triggers events of cellular lipotoxicity. Synergistically, multiple molecular stimuli are prompted during the infection, activating inflammasomes and Na/K-ATPase signalosome, leading to pro-inflammatory and metabolic alterations during leptospirosis. Leptospirosis involves diverse molecular mechanisms and alteration in patient inflammatory and metabolic status. Nonetheless, Na/K-ATPase is critical in the disease, and it is targeted by GLP, its components, and other molecules, such as fatty acids, that inhibit or trigger intracellular signaling through this enzyme. Herein, we overview the role of Na/K-ATPase during leptospirosis infection as a potential therapeutic target or an indicator of disease severity.

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The relationship of oleic acid/albumin molar ratio and clinical outcomes in leptospirosis

Cited by 4 publications

References 51 publications

Lipid oxidation dysregulation: an emerging player in the pathophysiology of sepsis

Lipid oxidation dysregulation: an emerging player in the pathophysiology of sepsis

Acute Kidney Injury Associated with Severe Leptospirosis: Fatal Re-Emerging Disease in Latin America

Cellular Pathophysiology of Leptospirosis: Role of Na/K-ATPase

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