Herbal teas can be harmful: a case of <i>Peganum harmala</i> induced coma in a patient with Parkinson’s disease

Çelik, Nazlı Durmaz; Akarsu, Fatma Ger; Özkan, Serhat; Özdemi̇r, Atilla Özcan; Aykaç, Özlem; Memmedova, Fergane

doi:10.1080/13554794.2021.1876092

Cited by 5 publications

(2 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Neurological, gastrointestinal, and cardiovascular symptoms accounted for 34.4%, 31.9%, and 15.8% of the cases of poisoning, respectively. Following the consumption of P. harmala seeds, patients apply to the clinic with complaints such as visual and auditory hallucinations, locomotor ataxia, nausea, vomiting, confusion, and agitation (88)(89)(90)(91)(92)(93)(94)(95)(96). Some cases of poisoning by P. harmala are listed in Table 3.…”

Section: Human Toxicitymentioning

confidence: 99%

Phytochemical, Pharmacological, and Toxicological Studies on Peganum harmala L.: An Overview of the Last Decade

GÖKKAYA,

RENDA,

SUBAŞ

et al. 2023

Clinical and Experimental Health Sciences

View full text Add to dashboard Cite

Objective: Plants have been used to treat ailments since the dawn of humanity. The use of medicinal plants for various purposes such as preventing diseases, treating diseases and supporting medical treatment is increasing day by day. On the other hand, medicinal plants are important sources of raw materials for the pharmaceutical industry. It has been demonstrated that Peganum harmala L. and the phytochemicals it contains have a wide variety of pharmacological activities. P. harmala and its active ingredients can be an important resource for the pharmaceutical industry. In this review, the phytochemistry, pharmacological effects, clinical studies, and toxicity of P. harmala are discussed under the current information. Methods: Studies on P. harmala were searched using Pubmed, Scopus, Science Direct databases, and Google Scholar search engine. As a result of the searches, 96 articles were included in the study. Results: The main group of secondary metabolites responsible for the biological activities of P. harmala is alkaloids. The plant and its isolated secondary plant compounds have been shown to have many pharmacological actions, counting antiamnestic, anticancer, antidepressant, antiinflammatory, cardiovascular, gastroprotective, hepatoprotective, nephroprotective, and vasodilator activities. Studies evaluating the plant's clinical effects have been carried out in recent years. However, it has been recorded in the literature that the use of P. harmala causes poisoning with symptoms such as neurosensory symptoms, visual hallucination, bradycardia, hypotension, agitation, tremor, ataxia, and vomiting. Conclusion: Considering the pharmacological effects, the number of studies on the efficacy and safety of P. harmala and its secondary metabolites should be increased.

show abstract

Section: Human Toxicitymentioning

confidence: 99%

Phytochemical, Pharmacological, and Toxicological Studies on Peganum harmala L.: An Overview of the Last Decade

GÖKKAYA,

RENDA,

SUBAŞ

et al. 2023

Clinical and Experimental Health Sciences

View full text Add to dashboard Cite

show abstract

“…Peganum harmala is also known as wild rue or Syrian rue. 11 It is also known as “Harmal” by locals. 12 It belongs to Zygophyllaceae family.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant, Antimicrobial, Phytochemical and FTIR Analysis of Peganum harmala (Fruit) Ethanolic Extract From Cholistan Desert, Pakistan

et al. 2022

View full text Add to dashboard Cite

The aim of this study was to evaluate antioxidant and antimicrobial potential of Peganum harmala fruit. Ethanolic extract was prepared and phytochemical screening showed the presence of a lot of chemical compounds. Fourier transform infrared spectroscopy (FTIR) spectra indicated the presence of organic acids, hydroxyl and phenolic compounds, amino groups, aliphatic compounds, and functional groups such as amide, ketone, aldehyde, aromatics, and halogen compounds. Antioxidant activity of the ethanolic extract of P. harmala by the DPPH method showed 71.4% inhibition, whereas IC50 ± SEM (μg/mL) was .406 ± .11. Antibacterial activity was performed against Escherichia coli, Bacillus subtilis, Bacillus pumilus, Micrococcus luteus, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis and Bordetella bronchiseptica. Maximum antibacterial activity was exhibited by Bacillus subtilis (24.33 ± 2 mm) and Bacillus pumilus (23.33 ± 2 mm). Zone of inhibition was 19 ± 2 mm by P. aeruginosa, and it was 18.33 ± 2 mm by Bordetella bronchiseptica. Staphylococcus aureus and Staphylococcus epidermidis had inhibitory effect in the range of 12.33 ± 2 mm and 13.66 ± 3 mm, respectively. 11.66 ± 2 mm and 10 ± 2 mm was zone of inhibition by Micrococcus luteus and E. coli, respectively. Antifungal activity was performed against Aspergillus terreus, Aspergillus fumigatus, Aspergillus flavus and Candida albicans. Ethanolic extract of P. harmala showed antifungal activity against Aspergillus flavus (5 ± 1 mm) and Candida albicans (4 ± 1 mm) . Mild antifungal activity was reported by Aspergillus fumigatus ( 3 ± 1 mm), whereas no activity was exhibited by Aspergillus terreus. Further research is needed in order to evaluate the cytotoxic effects of P. harmala as well.

show abstract

Toxicity evaluation of Algerian Peganum harmala seed hydromethanolic extract

Mounira

Diafat

Fatmi

et al. 2022

Toxicol. Environ. Health Sci.

View full text Add to dashboard Cite

Herbal teas can be harmful: a case of Peganum harmala induced coma in a patient with Parkinson’s disease

Cited by 5 publications

References 18 publications

Phytochemical, Pharmacological, and Toxicological Studies on Peganum harmala L.: An Overview of the Last Decade

Phytochemical, Pharmacological, and Toxicological Studies on Peganum harmala L.: An Overview of the Last Decade

Antioxidant, Antimicrobial, Phytochemical and FTIR Analysis of Peganum harmala (Fruit) Ethanolic Extract From Cholistan Desert, Pakistan

Toxicity evaluation of Algerian Peganum harmala seed hydromethanolic extract

Contact Info

Product

Resources

About