Step-by-step design of poly (ε-caprolactone) /chitosan/Melilotus officinalis extract electrospun nanofibers for wound dressing applications

Shahrousvand, Mohammad; Haddadi‐Asl, Vahid; Shahrousvand, Mohsen

doi:10.1016/j.ijbiomac.2021.03.046

Cited by 41 publications

(22 citation statements)

References 54 publications

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“…On the contrary, an increase of the concentration can result in thicker structures, and in some cases, the non-formation of the fibers due to high viscosity of the solution. A recent study evidenced the decrease of the diameter and the presence of beads in polycaprolactone (PCL) nanofibers when the polymeric concentration decreased from 13 to 8 wt% [21]. A similar result was also obtained in the processing of cellulose acetate (CA) and poly(vinyl chloride) (PVC) nanofibers.…”

Section: Polymer Concentrationsupporting

confidence: 53%

“…A higher amount of FA produced an increase of electrical conductivity solution, while an increase of the amount of DCM increased its surface tension. These effects in turn produced fibers with diameters between 1.5 μm and 220 nm [21]. Likewise, the use of the following solvent systems: acetone/N,Ndimethylacetamide, acetone/N,N-dimethylformamide and tetrahydrofuran/dimethylformamide at different ratios changed the morphology of PCL nanofibers.…”

Section: Type Of Solventmentioning

confidence: 93%

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Active Electrospun Mats: A Promising Material for Active Food Packaging

Vidal¹,

Muñoz‐Shugulí²,

Vidal³

et al. 2022

Electrospinning - Material Technology of the Future

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Nowadays, polymeric materials are widely used in the development of food packages. However, as food products with a greater safety and longer durability are required, packaging research area has been focused on the production of functional materials able to reach such further protection. The incorporation of natural and synthetics active compounds into the polymeric materials by traditional techniques has been the main used strategy, surging thus the research area of active food packaging. Furthermore, the latest science advances provide promising technologies for developing packaging materials, such as the electrospinning. This technique has allowed obtaining ultrathin electrospun mats based on micro- and/or nanofibers that have been proposed as novel active materials able to be applied as wrapper films, sachets and bags during the food packaging. In this chapter, the description of electrospinning, the effect of their principal parameters during the development of active food packaging materials as well as their current applications on different foodstuffs are presented.

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Section: Polymer Concentrationsupporting

confidence: 53%

Section: Type Of Solventmentioning

confidence: 93%

Active Electrospun Mats: A Promising Material for Active Food Packaging

Vidal¹,

Muñoz‐Shugulí²,

Vidal³

et al. 2022

Electrospinning - Material Technology of the Future

View full text Add to dashboard Cite

show abstract

“…Then they were soaked in PBS and incubated at 37 °C and weighed (wt) at different time intervals until saturated. The swelling rate was calculated [ 23 , 24 , 25 ].…”

Section: Methodsmentioning

confidence: 99%

A Marine-Derived Anti-Inflammatory Scaffold for Accelerating Skin Repair in Diabetic Mice

Huang

Guan

2021

Marine Drugs

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Reconstructing the typical analogue of extracellular matrix (ECM) in engineered biomaterials is essential for promoting tissue repair. Here, we report an ECM-mimetic scaffold that successfully accelerated wound healing through enhancing vascularization and regulating inflammation. We prepared an electrospun fiber comprising a brown alga-derived polysaccharide (BAP) and polyvinyl alcohol (PVA). The two polymers in concert exerted the function upon the application of PVA/BAP2 fiber in vivo; it started to reduce the inflammation and promote angiogenesis at the wound site. Our serial in vitro and in vivo tests validated the efficacy of PVA/BAP2 fiber. Particularly, PVA/BAP2 fiber accelerated the repair of a full-thickness skin wound in diabetic mice and induced optimal neo-tissue formation. Generally, our results suggest that, by mimicking the function of ECM, this fiber as an engineered biomaterial can effectively promote the healing efficiency of diabetic wounds. Our investigation may inspire the development of new, effective, and safer marine-derived scaffold for tissue regeneration.

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“…After that, they were soaked into PBS at 37 • C and weighed (wt) until saturated. Finally, the detailed value was calculated [25].…”

Section: Characterization Of the Fibersmentioning

confidence: 99%

An Electrospun Scaffold Loaded with an Enteromorpha Polysaccharide for Accelerated Wound Healing in Diabetic Mice

et al. 2022

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The design and development of innovative multifunctional wound dressing materials in engineered biomaterials is essential for promoting tissue repair. In this study, nanofibrous wound dressing materials loaded with anti-inflammatory ingredients were manufactured by a promising electrospinning strategy, and their capability for treating diabetic wounds was also investigated. A scaffold blend consisting of an Enteromorpha polysaccharide and polyvinyl alcohol (PVA) was fabricated. The in vitro and in vivo studies confirmed the efficacy of PVA/EPP1 fiber. We found that PVA/EPP1 fiber accelerated the repair of a full-thickness skin wound in diabetic mice. The results suggest that this scaffold could effectively shorten the wound healing time by inhibiting inflammatory activity, which makes it a promising candidate for the treatment of hard-to-heal wounds caused by diabetes.

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Step-by-step design of poly (ε-caprolactone) /chitosan/Melilotus officinalis extract electrospun nanofibers for wound dressing applications

Cited by 41 publications

References 54 publications

Active Electrospun Mats: A Promising Material for Active Food Packaging

Active Electrospun Mats: A Promising Material for Active Food Packaging

A Marine-Derived Anti-Inflammatory Scaffold for Accelerating Skin Repair in Diabetic Mice

An Electrospun Scaffold Loaded with an Enteromorpha Polysaccharide for Accelerated Wound Healing in Diabetic Mice

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