Effects of aerobic exercise on TC, HDL-C, LDL-C and TG in patients with hyperlipidemia

Abstract

Background: With the development of the social level and the improvement of living standards, people's dietary structure changes in the direction of high blood fat, high sugar and high fever, which leads to the occurrence of many diseases.Long-term increase in blood lipids can easily cause cholesterol to invade the walls of large blood vessels, deposit and accumulate, and promote the proliferation of smooth muscle cells and fibroblasts in the arterial intima, leading to coronary heart disease and atherosclerosis (AS) and other cardiovascular and cerebrovascular diseases. Methods: Electronic databases including Google Scholar, PubMed, Web of Science(WOS), the Cochrane Library, EMBASE and VIP Database for Chinese Technical Periodicals, China National Knowledge Infrastructure, and Wanfang. These databases will be searched to identify randomized controlled trials published January 1, 1980, and January 20, 2021. Language is limited with English and Chinese. We will use the standards provided in Cochrane Handbook 5.3.0 for quality assessment and risk assessment, and use Revman 5.3 software for meta-analysis. The primary outcomes are mainly evaluated by total cholesterol and triglyceride. Conclusion: The results of this study can provide a beneficial basis for the improvement of total cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol, and triglyceride in patients with hyperlipidemia.

Effects of exercise on high-fat diet–induced non-alcoholic fatty liver disease and lipid metabolism in ApoE knockout mice

“…In previous work, obesity induced through the administration of a HFD significantly elevated the levels of TC, TG, LDL-c, and HDL-c compared with those recorded in normal controls and these increases could be ameliorated by a treadmill exercise intervention [ 26 ]. In a meta-analysis, aerobic exercise exerted beneficial effects on TC, TG, LDL-c, and HDL-c in patients with hyperlipidemia [ 27 ]. In our study, the increases in these indices induced by the administration of HFD were not affected by the endurance exercise intervention, although AST and ALT levels were affected.…”

Modified highland barley regulates lipid metabolism, liver inflammation and gut microbiota in high-fat/cholesterol diet mice as revealed by LC-MS based metabonomics

“…In addition, the HFCD also significantly increased the serum 26 The increase in serum TG prevents blood dissolution of fibrin, enhances blood viscosity, develops thrombosis, and even leads to the occurrence of atherosclerosis. 27 In addition, LDL-C is the main carrier of plasma sterols in bodies, and cholesterol accumulated in vascular endothelial cells even leads to atherosclerosis. HDL-C plays an important biological role in transporting excess cholesterol from different parts of the organ to the specific organ liver.…”

Effects of Xylooligosaccharides on Lipid Metabolism, Inflammation, and Gut Microbiota in C57BL/6J Mice Fed a High-Fat Diet

“…The abnormal increase in serum TC content leads to the disorder of arterial endothelial cell function, which accelerates the occurrence and development of cerebrovascular diseases, especially atherosclerosis ( Nakamura et al, 2016 ). Increased serum TG content can inhibit the dissolution of fibrin in the blood, increase blood viscosity, promote thrombosis, and accelerate the development of atherosclerosis ( Zhao et al, 2021 ). On the contrary, the main carrier of plasma sterols in the body is LDL-C. Cholesterol is often accumulated in vascular endothelial cells, which can easily cause atherosclerosis.…”