Beneficial effects of angiotensin converting enzyme inhibition on scopolamine-induced learning and memory impairment in rats, the roles of brain-derived neurotrophic factor, nitric oxide and neuroinflammation

Beheshti, Farimah; Akbarī, Ḥamīd; Baghcheghi, Yousef; Mansouritorghabeh, Fatemeh; Sani, Sakineh Sadat Mortazavi; Hosseini, Mahmoud

doi:10.1080/10641963.2021.1901112

Cited by 13 publications

(9 citation statements)

References 52 publications

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“…The AChE inhibitory activity of minocycline has been reported in the literature [ 11 , 43 ]. A body of evidence has indicated that scopolamine impairs antioxidant defense and induces oxidative stress, which is accompanied by cholinergic system dysfunction [ 15 , 18 , 44 ]. In our study, an elevated level of AChE was observed under conditions of oxidative stress which was modified by minocycline.…”

Section: Discussionmentioning

confidence: 99%

“…Oxidative stress has been reported to have an important role in learning and memory impairment induced by scopolamine [ [15] , [16] , [17] ]. In addition, the administration of scopolamine resulted in neuroinflammation [ 18 ]. Evidence suggests multiple neuroprotective mechanisms of minocycline in different pathological conditions [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Minocycline alleviated scopolamine-induced amnesia by regulating antioxidant and cholinergic function

Ghalibaf¹,

Rajabian²,

Parviz³

et al. 2023

Heliyon

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Minocycline alleviated scopolamine-induced amnesia by regulating antioxidant and cholinergic function

Ghalibaf¹,

Rajabian²,

Parviz³

et al. 2023

Heliyon

Self Cite

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“…Our research supports the results of other studies on the reduction of TNFα by ACEI. Captopril used in coronary artery disease and ischemic heart diseases reduced inflammation in vivo by lowering the level of IL-6 [ 11 , 12 , 18 , 19 , 22 , 34 , 35 , 36 , 37 , 38 ], and increasing the level of TGFβ since the macrophages are in vivo activated with drugs [ 37 , 38 , 39 ]. Other authors found that non-stimulated macrophages can express the undetectable concentration of TGFβ in cell culture supernatant [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Activities of Captopril and Diuretics on Macrophage Activity in Mouse Humoral Immune Response

Bryniarski

Nazimek

Marcinkiewicz

2021

IJMS

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Hypertension is accompanied by the over-activation of macrophages. Diuretics administered alone or in combination with hypotensive drugs may have immunomodulatory effects. Thus, the influence of tested drugs on mouse macrophage-mediated humoral immunity was investigated. Mice were treated intraperitoneally with captopril (5 mg/kg) with or without hydrochlorothiazide (10 mg/kg) or furosemide (5 mg/kg) by 8 days. Mineral oil-induced peritoneal macrophages were harvested to assess the generation of cytokines in ELISA, and the expression of surface markers was analyzed cytometrically. Macrophages were also pulsed with sheep red blood cells (SRBC) and transferred to naive mice for evaluation of their ability to induce a humoral immune response. Tested drugs increase the expression of surface markers important for the antigen phagocytosis and presentation. SRBC-pulsed macrophages from mice treated with captopril combined with diuretics increased the secretion of antigen-specific antibodies by recipient B cells, while macrophages of mice treated with hydrochlorothiazide or furosemide with captopril increased the number of antigen-specific B cells. Tested drugs alter the macrophage secretory profile in favor of anti-inflammatory cytokines. Our results showed that diuretics with or without captopril modulate the humoral response by affecting the function of macrophages, which has significant translational potential in assessing the safety of antihypertensive therapy.

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“…While the enhancement of adult neurogenesis (~20%) is modest, it may contribute to the observed reduction in anxiety-like behavior [ 54 ]. Other effects of statin and ACEI treatments, such as reduced inflammation and enhanced BDNF levels, may also play a role [ 29 , 56 ] but were not examined in the present study. Vascularization was measured in the hippocampus as previous studies utilizing statins and anti-hypertensives indicated beneficial effects [ 15 , 35 ], but was not changed in the middle-aged mice.…”

Section: Discussionmentioning

confidence: 99%

Effects of Combined Anti-Hypertensive and Statin Treatment on Memory, Fear Extinction, Adult Neurogenesis, and Angiogenesis in Adult and Middle-Aged Mice

Yoo

Stremlau

Pinto

et al. 2021

Cells

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Hyperlipidemia and hypertension are modifiable risk factors for cognitive decline. About 25% of adults over age 65 use both antihypertensives (AHTs) and statins to treat these conditions. Recent research in humans suggests that their combined use may delay or prevent dementia onset. However, it is not clear whether and how combination treatment may benefit brain function. To begin to address this question, we examined effects of atorvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, and Captopril, an angiotensin-converting enzyme inhibitor (ACEI), administration on memory function, anxiety-like behavior, adult hippocampal neurogenesis and angiogenesis in adult and middle-aged male C57Bl/6J mice. In adult mice (3-months-old) combination (combo) treatment, as well as administration of each compound individually, for six weeks, accelerated memory extinction in contextual fear conditioning. However, pattern separation in the touchscreen-based location discrimination test, a behavior linked to adult hippocampal neurogenesis, was unchanged. In addition, dentate gyrus (DG) neurogenesis and vascularization were unaffected. In middle-aged mice (10-months-old) combo treatment had no effect on spatial memory in the Morris water maze, but did reduce anxiety in the open field test. A potential underlying mechanism may be the modest increase in new hippocampal neurons (~20%) in the combo as compared to the control group. DG vascularization was not altered. Overall, our findings suggest that statin and anti-hypertensive treatment may serve as a potential pharmacotherapeutic approach for anxiety, in particular for post-traumatic stress disorder (PTSD) patients who have impairments in extinction of aversive memories.

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Beneficial effects of angiotensin converting enzyme inhibition on scopolamine-induced learning and memory impairment in rats, the roles of brain-derived neurotrophic factor, nitric oxide and neuroinflammation

Cited by 13 publications

References 52 publications

Minocycline alleviated scopolamine-induced amnesia by regulating antioxidant and cholinergic function

Minocycline alleviated scopolamine-induced amnesia by regulating antioxidant and cholinergic function

Anti-Inflammatory Activities of Captopril and Diuretics on Macrophage Activity in Mouse Humoral Immune Response

Effects of Combined Anti-Hypertensive and Statin Treatment on Memory, Fear Extinction, Adult Neurogenesis, and Angiogenesis in Adult and Middle-Aged Mice

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