ErbB4 regulate extracellular dopamine through the p38 MAPK signaling pathway

Cao, Shu-Xia; Wen, Chen-xi; Sun, Rui; Han, Jia-xuan; Sun, Yu; Xu, Xinxin; Li, Xiaoming; Lian, Hong

doi:10.1016/j.neulet.2021.135830

Cited by 5 publications

(3 citation statements)

References 47 publications

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“…It was reported that the expression of GLP‐1 in chickens was upregulated through MAPK pathways 25 . In vitro experiments also proved that DA is regulated by MAPK signaling pathway 26 . It was reasonable to speculate that HL‐BX regulated the levels of brain‐gut neurotransmitters through the MAPK pathway.…”

Section: Resultsmentioning

confidence: 90%

“…25 In vitro experiments also proved that DA is regulated by MAPK signaling pathway. 26 It was reasonable to speculate that HL-BX regulated the levels of brain-gut neurotransmitters through the MAPK pathway. For this purpose, we examined and compared p38-MAPK protein expression in gastric tissue and brain tissue (Figure 6).…”

Section: The Different Regulation Of Hl-bx On the Expressions Of P38-...mentioning

confidence: 99%

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Huanglian‐banxia promotes gastric motility of diabetic rats by modulating brain‐gut neurotransmitters through MAPK signaling pathway

Chen,

Huang

et al. 2024

Neurogastroenterology Motil

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BackgroundGastric motility disorder is an increasingly common problem among people with diabetes. Neurotransmitters have been recognized as critical regulators in the process of gastric motility. Previous study has shown that herb pair huanglian‐banxia (HL‐BX) can improve gastric motility, but the underlying mechanism is still unclear. The aim of this study was to further investigate the role of HL‐BX in modulating brain‐gut neurotransmission to promote gastric motility in diabetic rats, and to explore its possible mechanism.MethodsThe diabetic rats were divided into five groups. Gastric emptying rate, intestinal propulsion rate, body weight, and average food intake were determined. Substance P (SP), 5‐ hydroxytryptamine (5‐HT), and glucagon‐like peptide −1 (GLP‐1) in the serum were measured by enzyme‐linked immunosorbent assay. Dopamine (DA) and norepinephrine (NE) in the brain were analyzed by high‐pressure liquid chromatography with a fluorescence detector. Protein expression of the tissues in the stomach and brain was determined by Western blot.Key ResultsHL‐BX reduced average food intake significantly, increased body weight, and improved gastric emptying rate and intestinal propulsion rate. HL‐BX administration caused a significant increase in SP, GLP‐1, and 5‐HT, but a significant decrease in DA and NE. Interestingly, HL‐BX regulated simultaneously the different expressions of MAPK and its downstream p70S6K/S6 signaling pathway in the stomach and brain. Moreover, berberine exhibited a similar effect to HL‐BX.ConclusionsThese results indicated that HL‐BX promoted gastric motility by regulating brain‐gut neurotransmitters through the MAPK signaling pathway. HL‐BX and MAPK provide a potential therapeutic option for the treatment of gastroparesis.

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Section: Resultsmentioning

confidence: 90%

Section: The Different Regulation Of Hl-bx On the Expressions Of P38-...mentioning

confidence: 99%

Huanglian‐banxia promotes gastric motility of diabetic rats by modulating brain‐gut neurotransmitters through MAPK signaling pathway

Chen,

Huang

et al. 2024

Neurogastroenterology Motil

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“…ERBB4 mediates amyloid β-induced neurotoxicity, which is a biomarker for Alzheimer’s disease 50 , and Neuregulin1-ERBB4 signaling regulates the inflammatory pain of electroacupuncture analgesia in the spinal cord 51 . Moreover, the function of ERBB4 in dopamine neurons is related to depression-like behaviors, and it regulates the homeostasis of extracellular dopamine and norepinephrine in catecholaminergic cells 52 . In animal models, ErbB4 (the homologous gene in mouse) has been shown to work with NRG1 to maintain glutaminergic activity in the amygdala, and ErbB4 is sufficient and crucial for tone-cued fear conditioning 53 .…”

Section: Discussionmentioning

confidence: 99%

Genome-wide association study identified six loci associated with adverse drug reactions to aripiprazole in schizophrenia patients

Wang

Mei

et al. 2023

Schizophr

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Aripiprazole is recommended for routine use in schizophrenia patients. However, the biological mechanism for the adverse drug reactions (ADRs) among schizophrenia patients with the antipsychotic drug aripiprazole is far from clear. To explore the potential genetic factors that may cause movement-related adverse antipsychotic effects in patients, we conducted an association analysis between movement-related ADRs and SNPs in schizophrenia patients receiving aripiprazole monotherapy. In this study, multiple ADRs of 384 patients were quantified within 6-week treatment, and the scores of movement-related ADRs at baseline and follow-up time points during treatment were obtained. The highest score record was used as the quantitative index in analysis, and genetic analysis at the genome-wide level was conducted. The SNP rs4149181 in SLC22A8 [P = 2.28 × 10−8] showed genome-wide significance, and rs2284223 in ADCYAP1R1 [P = 9.76 × 10−8], rs73258503 in KCNIP4 [P = 1.39 × 10−7], rs678428 in SMAD9 [P = 4.70 × 10−7], rs6421034 in NAP1L4 [P = 6.80 × 10−7], and rs1394796 in ERBB4 [P = 8.60 × 10−7] were found to be significantly associated with movement-related ADRs. The combined prediction model of these six loci showed acceptable performance in predicting adverse events [area under the curve (AUC): 0.84]. Combined with the function and network of the above genes and other candidate loci (KCNA1, CACNG1, etc.), we hypothesize that SLC22A8 and KCNIP4-Kv channel perform their respective functions as transporter or channel and participate in the in vivo metabolism or effects of aripiprazole. The above results imply the important function of ion transporters and channels in movement-related adverse antipsychotic effects in aripiprazole monotherapy schizophrenia patients.

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Shared genetics of psychiatric disorders and type 2 diabetes:a large-scale genome-wide cross-trait analysis

Ding

Ouyang

Wang

et al. 2023

Journal of Psychiatric Research

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ErbB4 regulate extracellular dopamine through the p38 MAPK signaling pathway

Cited by 5 publications

References 47 publications

Huanglian‐banxia promotes gastric motility of diabetic rats by modulating brain‐gut neurotransmitters through MAPK signaling pathway

Huanglian‐banxia promotes gastric motility of diabetic rats by modulating brain‐gut neurotransmitters through MAPK signaling pathway

Genome-wide association study identified six loci associated with adverse drug reactions to aripiprazole in schizophrenia patients

Shared genetics of psychiatric disorders and type 2 diabetes:a large-scale genome-wide cross-trait analysis

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