Prediction of cerebral perfusion pressure during CPR using electroencephalogram in a swine model of ventricular fibrillation

Kim, Tae Han; Kim, Heejin; Hong, Ki Jeong; Shin, Sang Do; Park, Yong Joo; Ro, Young Sun; Song, Kyoung Jun; Kim, Ki Hong; Choi, Dong Sun; Kang, Hyun Jeong

doi:10.1016/j.ajem.2021.02.051

Cited by 4 publications

(6 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As for animal models [7,[32][33][34][35][36], ventricular fibrillation was medically induced and treated following a standard protocol. In all these cases, EEG showed a good correlation with cerebral blood flow recovery.…”

Section: Resultsmentioning

confidence: 99%

“…In all these cases, EEG showed a good correlation with cerebral blood flow recovery. In 2 (50%) [7,34], EEG signal was used to derive a parameter called EEG-based brain resuscitation index (EBRI) that could be used as surrogate of cerebral perfusion pressure [7], and also showed moderate correlation with EtCO 2 [34].…”

Section: Resultsmentioning

confidence: 99%

“…However, using EtCO 2 thresholds alone for decision-making to stop resuscitation is not recommended, due to the absence of blind studies and the subsequent risk of self-fulfilling prophecy [6]. Furthermore, although EtCO 2 might be a surrogate marker for systemic circulation status, it does not account for cerebral perfusion pressure (CPP) [7].…”

Section: Rationalementioning

confidence: 99%

See 2 more Smart Citations

Electroencephalographic monitoring of brain activity during cardiac arrest: a narrative review

Roberti

Chiarini²,

Latronico³

et al. 2023

ICMx

View full text Add to dashboard Cite

Background To date cardiac arrest (CA) remains a frequent cause of morbidity and mortality: despite advances in cardiopulmonary resuscitation (CPR), survival is still burdened by hypoxic–ischemic brain injury (HIBI), and poor neurological outcome, eventually leading to withdrawal of life sustaining treatment (WLST). The aim of CPR is cardiac pump support to preserve organ perfusion, until normal cardiac function is restored. However, clinical parameters of target organ end-perfusion during CPR, particularly brain perfusion, are still to be identified. In this context, electroencephalography (EEG) and its derivatives, such as processed EEG, could be used to assess brain function during CA. Objectives We aimed to review literature regarding the feasibility of EEG and processed or raw EEG monitoring during CPR. Methods A review of the available literature was performed and consisted of mostly case reports and observational studies in both humans and animals, for a total number of 22 relevant studies. Results The research strategy identified 22 unique articles. 4 observational studies were included and 6 animal testing studies in swine models. The remaining studies were case reports. Literature regarding this topic consists of conflicting results, containing studies where the feasibility of EEG during CPR was positive, and others where the authors reached opposite conclusions. Furthermore, the level of evidence, in general, remains low. Discussion EEG may represent a useful tool to assess CPR effectiveness. A multimodal approach including other non-invasive tools such as, quantitative infrared pupillometry and transcranial Doppler, could help to optimize the quality of resuscitation maneuvers.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Rationalementioning

confidence: 99%

See 1 more Smart Citation

Electroencephalographic monitoring of brain activity during cardiac arrest: a narrative review

Roberti

Chiarini²,

Latronico³

et al. 2023

ICMx

View full text Add to dashboard Cite

show abstract

“…HQ-CPR showed significantly higher DBP than did LQ-CPR (median [IQR] HQ-CPR: 24 [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] mmHg, LQ-CPR: 22 [17][18][19][20][21][22][23][24][25][26][27] mmHg, p < 0.01). HQ-CPR showed higher ETCO 2 than did LQ-CPR (median [IQR] HQ-CPR: 23 [17][18][19][20][21][22][23][24][25][26] mmHg, LQ-CPR: 18 [14-22] mmHg) and higher CoPP than did LQ-CPR (median [IQR] HQ-CPR: 16 [8][9][10][11][12][13][14][15][16][17][18][19][20]…”

Section: Resultsmentioning

confidence: 99%

“…In a previous study, we developed an EEG-based brain index (EBRI) derived from EEG signals by machine learning techniques, which could estimate cerebral perfusion pressure (CePP) accurately in a porcine cardiac arrest model [21]. In this study, we showed that EBRI correlates with ETCO 2 , which is known as indicator of CPR quality using EEG signals in cardiac arrest swine models.…”

Section: Introductionmentioning

confidence: 92%

Correlation of EEG-based brain resuscitation index and end-tidal carbon dioxide in porcine cardiac arrest model

2021

View full text Add to dashboard Cite

Evaluation and monitoring perfusion of vital organs is important during resuscitation from cardiac arrest. We developed a non-invasive electroencephalogram (EEG) based brain resuscitation index (EBRI) as a physiologic indicator measuring organ perfusion during cardiopulmonary resuscitation (CPR) and evaluated the correlation of EBRI and end-tidal carbon dioxide (ETCO2). A randomized crossover experimental study using a porcine cardiac arrest model was designed. After 1 minute of untreated ventricular fibrillation, 10 periods of higher-quality CPR (compression depth 5 cm and compression rate 100/min) for 50 seconds and lower-quality CPR (compression depth 3 cm and compression rate 60/min) for 50 seconds were performed in alternation. EBRI was calculated from the single EEG channel with the lowest noise. Mixed-model analysis was conducted to compare the differences of hemodynamic parameters, ETCO2, and EBRI between higher-quality CPR periods and lower-quality CPR periods. Pearson’s correlation coefficient was calculated to assess correlation between EBRI and ETCO2. The experiment was performed on 5 female swine (44.6 ± 2.8 kg). Higher-quality CPR showed significantly higher delta EBRI (median [IQR] 0.1 [0.0–0.2]) than did lower-quality CPR (median [IQR] –0.1 [–0.2–0.0], p < 0.01). EBRI had a statistically moderate positive correlation with ETCO2 (r = 0.51). In this porcine cardiac arrest model, EBRI was successfully obtained during resuscitation and had a statistically moderate correlation with ETCO2.

show abstract

Development of artificial intelligence-driven biosignal-sensitive cardiopulmonary resuscitation robot

Kim,

Suh,

Kim

et al. 2024

Resuscitation

View full text Add to dashboard Cite

Prediction of cerebral perfusion pressure during CPR using electroencephalogram in a swine model of ventricular fibrillation

Cited by 4 publications

References 25 publications

Electroencephalographic monitoring of brain activity during cardiac arrest: a narrative review

Electroencephalographic monitoring of brain activity during cardiac arrest: a narrative review

Correlation of EEG-based brain resuscitation index and end-tidal carbon dioxide in porcine cardiac arrest model

Development of artificial intelligence-driven biosignal-sensitive cardiopulmonary resuscitation robot

Contact Info

Product

Resources

About