Leukocyte telomere length is inversely associated with a metabolic risk score in <scp>Mesoamerican children</scp>

Garfein, Joshua; Flannagan, Kerry S.; Rittman, Danielle S.; Ramírez‐Zea, Manuel; Villamor, Eduardo

doi:10.1002/ajhb.23596

Cited by 4 publications

(3 citation statements)

References 57 publications

(66 reference statements)

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“…12 In another cross-sectional study of school-age children, WC strongly predicted LTL in girls but not boys, 13 consistent with our main finding. Similarly, LTL was inversely related to WC in a cross-sectional study of Mesoamerican children, 14 in agreement with our results for girls. Additionally, in an intervention programme for adolescents with overweight or obesity, longer LTL at baseline predicted larger weight loss.…”

Section: Discussionsupporting

confidence: 92%

Prospective associations between leukocyte telomere length and adiposity in childhood

et al. 2021

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Leukocyte telomere length (LTL) is associated with obesity and may be involved in its aetiology, but few studies have focused on children and most have been cross-sectional.We assessed the relation of LTL with adiposity development in a prospective study of Colombian children. We quantified LTL at enrollment in 722 children aged 5-12 years and measured anthropometry annually for a median 6 years. Using mixed effects models, we estimated changes in adiposity measures including BMI and waist circumference (WC)-for-age z-scores in relation to baseline LTL z-score. In girls, longer LTL was linearly related to a lower increase in WC z-score from age 6 to 16 years. Every 1 SD LTL was associated with an adjusted 0.13 units lower increase in WC (95% CI: À0.23, À0.03; p = 0.01). In conclusion, longer LTL among girls in middle childhood is associated with smaller increases in WC, an indicator of abdominal adiposity.

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Section: Discussionsupporting

confidence: 92%

Prospective associations between leukocyte telomere length and adiposity in childhood

et al. 2021

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“…As shorter LTL is associated with systemic oxidative stress exposure and severity of metabolic disease, it is possible that our finding of longer LTL with increasing amounts of lobular inflammation may suggest alternate pathways, including potential future risk for cancer in these children 30,31 . Long-term longitudinal studies of pediatric patients with NAFLD have not yet been conducted.…”

Section: Discussionmentioning

confidence: 95%

Shorter leukocyte telomere length protects against NAFLD progression in children

Wojcicki

Gill

Wilson

et al. 2023

Sci Rep

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Leukocyte telomere length (LTL) gets shorter with each cell division and is also sensitive to reactive oxygen species damage and inflammatory processes. Studies in adults with non-alcoholic fatty liver disease (NAFLD) have found that increased fibrosis but not ALT levels are associated with shorter LTL. Few pediatric studies have been conducted; as such, we sought to evaluate potential associations between LTL and liver disease and liver disease progression in pediatric patients. Using data from the Treatment of NAFLD in Children (TONIC) randomized controlled trial, we assessed the potential predictive relationship between LTL and liver disease progression based on two successive liver biopsies over 96 weeks. We assessed the potential relationship between LTL and child age, sex, and race/ethnicity and features of liver disease including components of histology. We subsequently evaluated predictors for improvement in non-alcoholic steatohepatitis (NASH) at 96 weeks including LTL. We also assessed predictors of lobular inflammation improvement at 96 weeks using multivariable models. Mean LTL at baseline was 1.33 ± 0.23 T/S. Increasing lobular and portal inflammation were associated with longer LTL. In multivariable models, greater lobular inflammation at baseline was associated with longer LTL (Coeff 0.03, 95% CI 0.006–0.13; p = 0.03). Longer LTL at baseline was associated with worsening lobular inflammation at 96 weeks (Coeff 2.41, 95% CI 0.78–4.04; p < 0.01). There was no association between liver fibrosis and LTL. The association between LTL and pediatric NASH does not parallel adults with no association between fibrosis stage and NASH. Conversely, longer LTL was associated with more lobular inflammation at baseline and increased lobular inflammation over the 96-week period. Longer LTL in children may indicate greater risk for future complications from NASH.

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“…Regarding the intensity of PA, the findings are controversial. In the context of obesity, several exercise interventions assessed the possible role of PA on TL [ 40 , 44 ], but just one showed significant results [ 44 ]. Sjögren et al found that a decrease in sitting time during weekdays was associated with longer TL in older adults who were overweight [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

Telomere Length and Pediatric Obesity: A Review

Azcona

2021

Genes

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Obesity is a chronic disease, which needs to be early detected early and treated in order prevent its complications. Changes in telomere length (TL) have been associated with obesity and its complications, such as diabetes mellitus and metabolic syndrome. Therefore, we conducted a systematic review to summarize results of studies that have measured TL in children and adolescents with obesity. Fourteen studies aiming to assess TL in pediatric patients with either obesity or who were overweight were included in this review. In conclusion, obesity and adiposity parameters are negatively associated with TL. Shorter telomeres are observed in children with obesity compared with their lean counterparts. Factors involved in obesity etiology, such as diet and physical activity, may contribute to maintenance of TL integrity. In the long term, TL change could be used as a biomarker to predict response to obesity treatment.

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Leukocyte telomere length is inversely associated with a metabolic risk score in Mesoamerican children

Cited by 4 publications

References 57 publications

Prospective associations between leukocyte telomere length and adiposity in childhood

Prospective associations between leukocyte telomere length and adiposity in childhood

Shorter leukocyte telomere length protects against NAFLD progression in children

Telomere Length and Pediatric Obesity: A Review

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