Renal impairment assessment on adults living nearby a landfill: Early kidney dysfunction biomarkers linked to the environmental exposure to heavy metals

Cabral, Mathilde; Garçon, Guillaume; Touré, Aminata; Bah, Fatoumata; Dewaele, Dorothée; Bouhsina, Saâd; Cazier, Fabrice; Faye, Adama; Fall, Mamadou; Courcot, Dominique; Verdin, Anthony

doi:10.1016/j.toxrep.2021.02.009

Cited by 20 publications

(9 citation statements)

References 44 publications

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“…Cd has a long half-life, and once absorbed through the plasma membrane’s calcium channel, it builds up in the body permanently due to its binding to the cytoplasm and nuclear molecules. Cd accumulation in the tissues triggers early oxidative stress and various pathological conditions, particularly in the liver and kidneys ( Larregle et al, 2008 ; Cabral et al, 2021 ). Oxidative distress is renowned for being initiated when the produced ROS, such as superoxide anions (O 2 •− ), hydroxyl radicals (OH • ), and hydrogen peroxide (H 2 O 2 ), overrides the endogenous antioxidant's capacity ( Abdeen et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

The Combination of Tamarindus indica and Coenzyme Q10 can be a Potential Therapy Preference to Attenuate Cadmium-Induced Hepatorenal Injury

et al. 2022

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Cadmium (Cd) is a hazardous environmental pollutant that menaces human and animal health and induces serious adverse effects in various organs, particularly the liver and kidneys. Thus, the current study was designed to look into the possible mechanisms behind the ameliorative activities of Tamarindus indica (TM) and coenzyme Q10 (CoQ) combined therapy toward Cd-inflicted tissue injury. Male Wistar rats were categorized into seven groups: Control (received saline only); TM (50 mg/kg); CoQ (40 mg/kg); Cd (2 mg/kg); (Cd + TM); (Cd + CoQ); and (Cd + TM + CoQ). All the treatments were employed once daily via oral gavage for 28 consecutive days. The results revealed that Cd exposure considerably induced liver and kidney damage, evidenced by enhancement of liver and kidney function tests. In addition, Cd intoxication could provoke oxidative stress evidenced by markedly decreased glutathione (GSH) content and catalase (CAT) activity alongside a substantial increase in malondialdehyde (MDA) concentrations in the hepatic and renal tissues. Besides, disrupted protein and lipid metabolism were noticed. Unambiguously, TM or CoQ supplementation alleviated Cd-induced hepatorenal damage, which is most likely attributed to their antioxidant and anti-inflammatory contents. Interestingly, when TM and CoQ were given in combination, a better restoration of Cd-induced liver and kidney damage was noticed than was during their individual treatments.

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Section: Discussionmentioning

confidence: 99%

The Combination of Tamarindus indica and Coenzyme Q10 can be a Potential Therapy Preference to Attenuate Cadmium-Induced Hepatorenal Injury

et al. 2022

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“…However, both the blood and urinary Pb levels were far below the body burdens of residents recruited from a zinc-smelting area in China (B-Pb: 131.2 µg/L; U-Pb: 20.6 µg/g creatinine)(Chen et al 2019). When compared to a study on residents living in the area surrounding a land ll in France (B-Pb: 120.95 µg/L; U-Pb: 4.21 µg/g creatinine)(Cabral et al 2021), the blood Pb levels were lower in our study, but the urinary Pb levels were higher. Moreover, the population living in the central area near the non-ferrous metal plants in Ath, Belgium (B-Pb: 31.2 µg/L in men, 22.5 µg/L in women; U-Cr: 0.13 µg/g creatinine in men, 0.17 µg/g creatinine in women; U-Ni: 0.65 µg/g creatinine in men, 1.30 µg/g creatinine in women)(Fierens et al 2016), demonstrated similar blood Pb levels to those in our study, although the Belgian study had higher urinary Cr levels and lower urinary Ni levels.…”

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confidence: 83%

Insights into the health status of the general population living near an electroplating industry zone: metal elevation and renal impairment

Lai

et al. 2022

Preprint

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To evaluate the body burdens of metals and metalloids associated with renal dysfunction in residents living near electroplating industries, a cross-sectional study was conducted in 2016 in Zhejiang Province, China. We recruited 236 subjects and performed physical examinations; determined the blood and urinary levels of arsenic (As), cadmium (Cd), chromium (Cr), manganese (Mn), nickel (Ni), lead (Pb), antimony (Sb), and selenium (Se) by an inductively coupled plasma mass spectrometer (ICP-MS); and measured three renal impairment biomarkers, namely Nacetyl-β-D-glucosaminidase (NAG), retinol binding protein (RBP), and β2-microglobulin (BMG). The proportion of abnormal nasal symptoms in the exposure group (10.1%) was much higher than in the control group (0; p < 0.05). Both the blood and urinary levels of As, Cd, and Se in the exposure group were significantly higher than the levels in the control group (p < 0.05). The blood levels of Mn and Pb, as well as the urinary levels of Cr and Ni, in the exposure group were significantly higher compared to the control group (p < 0.05). The exposure group demonstrated higher levels of NAG, RBP, and BMG compared to the control group (0.51 vs. 0.14 mg/g creatinine, 12.79 vs. 9.26 IU/ g creatinine, 1.39 vs. 0.78 mg/g creatinine, respectively; p < 0.05). Urinary BMG was positively correlated with urinary Cd levels (r = 0.223, p < 0.05), while urinary RBP was correlated with blood Cd levels (r = 0.151, p < 0.05) and urinary Cd, Cr, Ni, and Se levels (r = 0.220, 0.303, 0.162, and 0.306, respectively; p < 0.05). In conclusion, our study indicated that residents living in the vicinity of electroplating industries were bearing high body burdens of certain metals and metalloids associated with nonnegligible renal dysfunction.

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“…to cause kidney damage and dysfunction in Senegal. 119 Multiple studies have suggested a higher risk of renal impairment with environmental cadmium and lead exposure. 109 It is also reported that environmental metal exposures can cause diabetes, hypertension and dyslipidemia, thus contributing even further to the CKD risk.…”

Section: Ckd and Environmental Stressorsmentioning

confidence: 99%

Chronic kidney disease of unknown aetiology in Africa: A review of the literature

Fiseha,

Ekong,

Osborne

2023

Nephrology

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During the last two decades, an epidemic of a severe form of chronic kidney disease (CKD) unrelated to traditional risk factors (diabetes and hypertension) has been recognized in low‐ to middle‐income countries. CKD of unknown aetiology (CKDu) mainly affects young working‐age adults, and has become as an important and devastating public health issue. CKDu is a multifactorial disease with associated genetic and environmental risk factors. This review summarizes the current epidemiological evidence on the burden of CKDu and its probable environmental risk factors contributing to CKD in Africa. PubMed/Medline and the African Journals Online databases were searched to identify relevant population‐based studies published in the last two decades. In the general population, the burden of CKD attributable to CKDu varied from 19.4% to 79%. Epidemiologic studies have established that environmental factors, including genetics, infectious agents, rural residence, low socioeconomic status, malnutrition, agricultural practise and exposure to agrochemicals, heavy metals, use of traditional herbs, and contaminated water sources or food contribute to the burden of CKD in the region. There is a great need for epidemiological studies exploring the true burden of CKDu and unique geographical distribution, and the role of environmental factors in the development of CKD/CKDu.image

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Renal impairment assessment on adults living nearby a landfill: Early kidney dysfunction biomarkers linked to the environmental exposure to heavy metals

Cited by 20 publications

References 44 publications

The Combination of Tamarindus indica and Coenzyme Q10 can be a Potential Therapy Preference to Attenuate Cadmium-Induced Hepatorenal Injury

The Combination of Tamarindus indica and Coenzyme Q10 can be a Potential Therapy Preference to Attenuate Cadmium-Induced Hepatorenal Injury

Insights into the health status of the general population living near an electroplating industry zone: metal elevation and renal impairment

Chronic kidney disease of unknown aetiology in Africa: A review of the literature

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