Maternal stress and depression are associated with respiratory phenotypes in urban children

Ramratnam, Sima; Lockhart, Alexandre; Visness, Cynthia M.; Calatroni, Agustin; Jackson, Daniel J.; Gergen, Peter J.; Bacharier, Leonard B.; O’Connor, George T.; Sandel, Megan; Kattan, Meyer; Wood, Robert A.; Gern, James E.

doi:10.1016/j.jaci.2021.03.005

Cited by 15 publications

(10 citation statements)

References 38 publications

(42 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is fairly consistent with the results of our study, although we observed an association earlier at 48 months (4 years of age) 5 . Also in line with our results, Ramratnam et al assessed the associations between maternal stress and depression during pregnancy and early life, and recurrent wheezing utilizing the Urban Environment and Childhood Asthma (URECA) birth cohort 12 and found an association between cumulative maternal depression in the first 3 years of life and recurrent wheezing 12 . However, we did not find any associations between prenatal depression and any of our outcomes like previous studies have reported 9,11 .…”

Section: Discussionsupporting

confidence: 93%

“… 5 Also in line with our results, Ramratnam et al assessed the associations between maternal stress and depression during pregnancy and early life, and recurrent wheezing utilizing the Urban Environment and Childhood Asthma (URECA) birth cohort 12 and found an association between cumulative maternal depression in the first 3 years of life and recurrent wheezing. 12 However, we did not find any associations between prenatal depression and any of our outcomes like previous studies have reported. 9 , 11 Differences in our findings may be attributable to our classification of depression (e.g., limited only to the prenatal period), the prevalence of our outcome, and sample size.…”

Section: Discussionsupporting

confidence: 87%

“…Prospective birth cohorts examining maternal depression at different time points in relation to wheeze and asthma development in early childhood have produced mixed results. 5 , 9 , 12 A Canadian population‐based birth cohort study found that continued exposure to maternal anxiety or depression from birth into early childhood was associated with a twofold increase in the risk of asthma at age 7 years. 5 This is fairly consistent with the results of our study, although we observed an association earlier at 48 months (4 years of age).…”

Section: Discussionmentioning

confidence: 99%

“…They did not identify a critical exposure period but rather reported that chronic exposure to maternal depression and anxiety is associated with offspring asthma. Ramratnam et al 12 concluded that maternal stress and depression in the first 3 years were positively associated with respiratory illnesses and a moderate‐wheeze‐low‐atopy‐phenotype.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Longitudinal assessment of maternal depression and early childhood asthma and wheeze: Effect modification by child sex

Alcala

Scott

Tamayo‐Ortiz

et al. 2022

Pediatric Pulmonology

View full text Add to dashboard Cite

Background: Studies report associations between maternal mental health and adverse respiratory outcomes in children; however, the impact of timing and duration of maternal distress remains understudied. We sought to longitudinally examine associations between maternal depression and childhood asthma and wheeze, and explore sex differences. Methods: Maternal depression (n = 601) was assessed using the Edinburgh Depression Scale questionnaire, dichotomized at a clinically relevant cutoff (>12) (a) during pregnancy, (b) postpartum, and (c) postpartum and subsequent time points postnatally (recurrent depression). Report of wheeze in the past 12 months (current wheeze) and asthma were obtained using the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire at 48 and 72 months. Associations were analyzed using a modified Poisson regression adjusted for covariates, and in interaction models.Results: Both postpartum and recurrent depression were associated with higher risk of current wheeze (relative risk [RR]: 1.87, 95% confidence interval [CI]: 1.21, 2.90;

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Longitudinal assessment of maternal depression and early childhood asthma and wheeze: Effect modification by child sex

Alcala

Scott

Tamayo‐Ortiz

et al. 2022

Pediatric Pulmonology

View full text Add to dashboard Cite

show abstract

“…A population-based study found an increased incidence of atopic dermatitis and asthma in children born to mothers exposed to prenatal stress [43]. The Urban Environment and Childhood Asthma Study (URECA) study described an association between maternal stress and depression in early life and increased viral respiratory illness and nonatopic wheeze [44]. A meta-analysis examining prenatal mood disorders and asthma found an increased association between maternal depression and anxiety and childhood asthma, but not atopic dermatitis [45].…”

Section: Direct Prenatal Exposures and Respiratory Health Outcomesmentioning

confidence: 99%

Prebirth effects of climate change on children's respiratory health

Yadav

Pacheco

2023

Current Opinion in Pediatrics

View full text Add to dashboard Cite

Purpose of reviewTo date, there is no evidence that humanity will implement appropriate mitigation measures to avoid the catastrophic impact of climate change on the planet and human health. Vulnerable populations such as pregnant women and children will be the most affected. This review highlights epidemiologic data on climate change-related prenatal environmental exposures affecting the fetus and children's respiratory health.Recent findingsResearch on outcomes of prenatal exposure to climate change-related environmental changes and pediatric pulmonary health is limited. In addition to adverse pregnancy outcomes known to affect lung development, changes in lung function, increased prevalence of wheezing, atopy, and respiratory infections have been associated with prenatal exposure to increased temperatures, air pollution, and maternal stress. The mechanisms behind these changes are ill-defined, although oxidative stress, impaired placental functioning, and epigenetic modifications have been observed. However, the long-term impact of these changes remains unknown.SummaryThe detrimental impact of the climate crisis on pediatric respiratory health begins before birth, highlighting the inherent vulnerability of pregnant women and children. Research and advocacy, along with mitigation and adaptation measures, must be implemented to protect pregnant women and children, the most affected but the least responsible for the climate crisis.

show abstract