A central role of the visual system is to integrate inputs from both eyes to form one coherent visual perception. The superior colliculus (SC) plays a central role in visual processing, gaze orientation and vergence eye movements necessary for binocular vision. Indeed, the SC receives direct inputs from both the contralateral and ipsilateral eye and binocularly-modulated neurons have been identified in the SC of multiple species. However, evidence for binocular processing in rodents, particularly mice, has not been functionally confirmed. In this study we recorded visually-evoked activity in the mouse SC while presenting visual stimuli to each eye individually or both together and reveal a surprising diversity of binocularly-modulated responses. Strikingly, we found that ~2/3 of all identified neurons in the anteromedial SC were binocularly-modulated. Furthermore, we identified four binocular subtypes based on their differential responses under varying ocularities of stimulus presentation. Interestingly, we found both orientation- and direction- selective (OS and DS, respectively) neurons in all four binocular subtypes. And, tuning properties of binocular neurons were distinct from neighboring monocular neurons, exhibiting more linear spatial summation. Together, these data suggest that binocular neurons are prevalent in the anteromedial SC of the mouse. Additionally, the distinct tuning properties of binocular neurons suggest a previously unappreciated complexity of visual processing in the SC, which may contribute to binocular perception.