Clinical and laboratory findings in COVID-19 adult hospitalized patients from Alborz province / Iran: comparison of rRT-PCR positive and negative

Abstract

Background The novel coronavirus disease 2019 (COVID-19) was emergency turned into global public health after the first patients were detected in Wuhan, China, in December 2019. The disease rapidly expanded and led to an epidemic throughout China, followed by the rising number of cases worldwide. Given the high prevalence of COVID-19, rapid and accurate diagnostic methods are immediately needed to identify, isolate and treat the patients as soon as possible, decreasing mortality rates and the risk of public contamination by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2). Methods This case-control study was conducted in two hospitals in Alborz Province in Iran. All recruited cases in this study were symptomatic adults hospitalized as COVID-19 patients with compatible Computed tomographic (CT) scan findings and available rRT-PCR results. The patients were recruited in this study. The patients were categorized into positive and negative rRT-PCR groups and evaluated for symptoms, initial vital signs, comorbidity, clinical and laboratory findings. Finally, the results were assessed by SPSS software. Results Between March 5 to April 5, 2020, 164 symptomatic COVID-19 patients were studied. In total, there were 111 rRT-PCR positive (67.6%) and 53 rRT-PCR negative patients (32.4%). In terms of statistics, the frequency of symptoms revealed no difference, except for cough (P.V:0.008), dizziness (PV: 0.048), and weakness (P.V:0.022). Among initial vital signs, PR (P.V:0.041) and O2 Saturation (PV: 0.014) were statistically different between the two groups. Evaluation of comorbidities revealed no difference except for hyperlipidemia (P.V:0.024). In the comparison of laboratory findings, only WBC count (PV: 0.001), lymphocyte count (PV: 0.001), and Hb (P.V:0.008) were statistically different between the two groups. Conclusion In case of the negative rRT-PCR result, it is necessary to take a logical approach, and we recommended that the physician decides according to clinical manifestations, laboratory findings, and positive CT results.

Clinical and laboratory findings and PCR results in severe and non-severe COVID19 patients based on CURB-65 and WHO severity indices

“…Oropharyngeal sampling for COVID-19 rRT-PCR was done on admission for all the patients using the same protocol performed by well-trained staff and rRT-PCR device operators. In our study, 111 patients were rRT-PCR positive (67.6%), and 53 were rRT-PCR negative (32.4%) [17].…”

Hyperlipidemia, COVID-19 and acute pancreatitis: A tale of three entities

“…Thirty-four papers were reviewed after screening, which reported the incidence of hyperlipidemia in COVID-19 patients ( Table 2 ). 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 The incidence of hyperlipidemia ranged from 0.30% to 81.82% in COVID-19 patients among different studies. Potential reasons for the variations could be: 1) Regional factors led to the difference in baseline lipids levels; 2) The definition of hyperlipidemia varied in different studies.…”

The Immunological Therapeutic Strategies for Controlling Multiple Sclerosis: Considerations during the COVID-19 Pandemic

“…Serology tests of IgM and IgG, nucleic acid assays, and gene sequencing have all been used to confirm the diagnosis of COVID-19. Moreover, it is frequently diagnosed via computed tomographic (CT) imaging; however, a chest CT scan may not be able to distinguish this disease from other viral causes of pneumonia [ 33 , 34 ].…”